Conserved Protein Domain Family
CDC14

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pfam08045: CDC14 
Cell division control protein 14, SIN component
Cdc14 is a component of the septation initiation network (SIN) and is required for the localization and activity of Sid1. Sid1 is a protein kinase that localizes asymmetrically to one spindle pole body (SPB) in anaphase disappears prior to cell separation.
Statistics
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PSSM-Id: 336911
View PSSM: pfam08045
Aligned: 43 rows
Threshold Bit Score: 168.575
Threshold Setting Gi: 74588834
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121924962    1 MEALLSLAFDNIASKDTQK--IRKGLRQIEGMLAQIClsgs---kskQSTPGHR------RNASAINLGEQq-----EST 64
gi 74588834     1 MEQELTQIINLLTSNELPT--TLTGLEQTHKLLMSLL----------PSIKQYQnlltntNNSALMYNQRH------IKQ 62
gi 296424388    1 MEDLLSTSFDLLSSYDPIH--IRKGLRCLEGFLAKMClq-------vPPTPSKG------GARTA----GAa-----NSS 56
gi 452846870    1 MESLLSPSFDNISSRDSTK--IRKGLRQIEGLLAQICla------kaGSRSPNK------RKSSALDGGGKq-----HGQ 61
gi 927375673    4 fqeylenvliNCNRRDHEQ--VKLGLSELDELLTKLCvlkydeltyePSAVRKT------GNSSSIVERQAtl--seSGL 73
gi 575512453    7 eleasiLKIKDLLNADPSKqnLADAIDLLNSLLQSMM----------PSI-QAQ------RTPMTM----Ap-----FSA 60
gi 1030125951   1 MESLLSLSFDNISSRDSSK--IRKGLRQIEGLLAQICls------raGSRSPHK------RKSSALDDKKLqqqqqqQGS 66
gi 398409490    1 MENLLSVAFDNLSSRDGQK--IRKGCRQVENLLAQILls------kpNSRSPHK------RKSSALNDTKQ------QGT 60
gi 627800415    1 MESLLSLSFSNLSARDTSK--IRKGLRQIEGLLAQICls-------sNRLSPQK------RKTSASSEEVR-------GV 58
gi 615408881    1 MEALLSLSFDNITSKDSSK--IRKGLRQIEGLLAQIClsq----kndPAAAKHK------RNGSASKKTSS--------E 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121924962   65 PKKLGQLSEdpa---------freFFRLQEGFEWNVATRVADCLERllgmgsSkdGQNDILIlsSLSNLQGLLLLHSPSR 135
gi 74588834    63 NRDLQQLIQ---------------FQILQDNFQYNLLQYLLPIYDK------YelTLNDYLL--SNQIIQGILLIHPNSK 119
gi 296424388   57 VVGVTSRPKdaa---------fkeFLRLQSGFELNVTIRLISCLERllgrtnN--GQNNLLIlsTLDLIQGMLLLHPQSR 125
gi 452846870   62 VKGLADLKQdpa---------freFFRLQEGFQWNVASRIMSTLEClmgmgnP--SETDLLIlaALELLQGILLLHPHSK 130
gi 927375673   74 ANSLESHYQrrwklpkvgdvvfgeFLTLQDKVQYNVVSQLIQIIPFvs---tF--KENESLRv-LFRILQGCFLLHPPSR 147
gi 575512453   61 NSSSSKLVR---------------FVKLQDNFRFSLVLSIDRYLDWiyd---nisTVDSASIvqLNRLLQGLLLIHSPSR 122
gi 1030125951  67 TKQLGELKQdpa---------freFFRLQEGFQWNVASRLVQSIDCllgmgnP--SDTDLLIlsALDLLQGVLMLHPPSK 135
gi 398409490   61 SKQLDELKQdpa---------freFFRLQEGFQYNVASRLMSTLEClmgmgnP--SSTDLLIlaALDLLQGVLLLHPPSK 129
gi 627800415   59 CKLLGDLRKdaa---------freFFRLQEGFRWNVASRLIAVLERlmgmhsA--SSTNLLIlsTLDLLQGILLLHPPSR 127
gi 615408881   61 PKSLGALHGdpa---------freFFRLQEGFEWNVATRLIACLERllgmgaS--GQSDILIlsALDLMQGILLLHPPSR 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121924962  136 IIFG-REVYMNLILDLLD-------------PYNCPAIQSQALLVLVTALLATPQNTRTFEHMDG------LLT----VT 191
gi 74588834   120 RIFSiNHHNMKIILDLLDgcnntnnnnnkdsVNDNMKLSISLISTLIHILLKNYDNYRIFEDLNGc----sILIkhfkLS 195
gi 296424388  126 KLFA-REIHMNVLLDLLD-------------AESNDAVQCATLLTLVCGLLDNPTNTRTFESLDG------LAT----VT 181
gi 452846870  131 CLFG-RETHMTLLLDLLD-------------SANPPRIQSQALLVLVAALLDCPQNTRTFEGIDG------LLT----VT 186
gi 927375673  148 NLIT-YESKMWVLLEFLS-------------PRYSPQVIEALIPVLVSSLVRNVPNIRIFERLGGpqylceLLThksdVA 213
gi 575512453  123 SIFS-NTTDMRKILRFVElg----------sPAVPFEVTISFITTLLHILIKNLDNFRVFESCNGc----sILIsklkIS 187
gi 1030125951 136 CLFN-RESHMNLLLDLLD-------------SMNPPKIQSQALLVLVAALIDQPRNTRTFEAIDG------LLT----VT 191
gi 398409490  130 CLFH-REIHMNMLLDLLD-------------ASNPPKIQSHALLVLVAALLGQPRNTRTFEAIDG------LLT----VT 185
gi 627800415  128 TLFN-REDYMNLLLDLLD-------------ATNPPSVQSQALLVLVTALLDCPANARAFEAIDG------LLT----VT 183
gi 615408881  130 ALFS-REIYMNLLLDLLD-------------CGECPSIQSRTMLVLVTALLATPANTRTFESLDG------LLT----VT 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121924962  192 SL------------FKDEETTQN-------VKVKLLEFLYFYLMPETpapslqrspsklaaafd---------------- 236
gi 74588834   196 SFenindqnntntnTNSNNNNNEdeelnnnSNFKIIEFLMLYLSEEIdn------------------------------- 244
gi 296424388  182 SL------------FKRRDTPRE-------VKLKILEFLYFYLMPEVpspsaplprgq---------------------- 220
gi 452846870  187 SL------------FKSRSTTRD-------VKMRSLEFLYFYLMPEAgvspvsttnsapntailhrdldk-----yispf 242
gi 927375673  214 SL------------AREW---KE-------VQVKVLEFLFFYLIPESqslepkssfrrpvaskn---------------- 255
gi 575512453  188 DLsvpkksiennssMKS-ANQQM-------LNFKIIEFLIFYLNDESesq------------------------------ 229
gi 1030125951 192 SL------------FKSRSTTKE-------VKMRSLEFLYFYLMPESpilpwshasapnsavlqrggvdhhhrsftalae 252
gi 398409490  186 SL------------FKSRSTTKE-------VKMRSLEFLYFYLMPEVptlpftsssapntavmgrngag-------khdl 239
gi 627800415  184 SL------------FRSRSTAQE-------VKMRTLEFLYFYLMPEAqpktahgalnttasptrledga--------ghs 236
gi 615408881  186 SL------------FKSRSTAST-------VKLKIMEFLYFYLMPETptipggaksnvmgldrsss-------------q 233
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 121924962  237 --rrtssangddgggaskKNTRSQEEKQHLLGKYLSN-VDA-LVEDLQESAPF 285
gi 74588834   245 -----------------sGGGKSIQEKSQFFINDFPE-IDS-LIENLNQLNNL 278
gi 296424388  221 --------sersssrkeaRAEKTTEEKQRMLGEFMSN-VEG-LVADLKESQPF 263
gi 452846870  243 agharthsgdsmdidykdADMRTQGEKQQLLGQYLSN-VSE-LVADLQDTAPF 293
gi 927375673  256 ------eklsnvknhedghrrkgTNEKATILNRYLNGeITKgLVTELQTSKPF 302
gi 575512453  230 ---------------gfdGKKKSIKEKSNYFRNDFPD-IDN-LIESLNDLKNi 265
gi 1030125951 253 harthsgdameideefldVDVRSIEDKQELLGQYINN-VEE-LVQDLQESGPF 303
gi 398409490  240 radharthsgdmdiddndLDTRSTDDKQMLLGRYLSN-VAE-LVGDLEESAPF 290
gi 627800415  237 qthsgdsggpmdideeedRVTKNTEEKQKLLGEHLSN-VAE-LVRDLREHAlf 287
gi 615408881  234 lmtafdrktrerrmsdpsDETKTTEEKQALLGRYLSN-VED-LVQDLRDSAPF 284
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