Conserved Protein Domain Family
NPCC

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pfam08058: NPCC 
Nuclear pore complex component
Proteins containing this domain are components of the nuclear pore complex. One member of this family is Nucleoporin POM34, which is thought to have a role in anchoring peripheral Nups into the pore and mediating pore formation.
Statistics
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PSSM-Id: 311828
View PSSM: pfam08058
Aligned: 24 rows
Threshold Bit Score: 81.5576
Threshold Setting Gi: 629636166
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588833  218 GSWENPIVKEAISRQ-INL--EYQMKSLIRNIIYLMIFILFKSSISKLLvlll---narS-------------------- 271
gi 74610728   87 GFFENPVLEKLAERS-VNK--SLEVQKIINNVLLYLLWNLITKFILLYLdhts---sgqK-------------------- 140
gi 74695979  129 GNYENPALAAFTRRV-VNK--EQEIKRIIANVWTLLIWNLVYKFLGLFLqssr---tgrF-------------------- 182
gi 366992904 139 GNFESPVLVNLLQRS-VSK--EQETQTIIANLVFFFVWNLIVKFVGLYF----------Khttngrmvllkinkklwslg 205
gi 403218536  80 GSFENPVLDKVISRT-INK--ESEFQVVVTNVLIFFLWNLLYKSTQLLLehsaygrklsK-------------------- 136
gi 410083451 138 GNFENPILGKLVKRS-ISK--EFEIQKIIINVISIALFNLLSKFSILFInhskvgrrfhL-------------------- 194
gi 401624711  40 GNFESPVLRELSRRT-VNK--ELESQRIITNAIAFAVWNLLVKFISFFRdnth---vgmQ-------------------- 93
gi 401841684  40 GNFESPVLKELSRRT-VNK--ELETQRIMTSAIAFALWNLLMKFIRFFRdnth---vgtQ-------------------- 93
gi 365764305  40 GNFESPVLKELSRRT-VNK--EMETQRIMTNVIAFAFWNLLVKFIKFFWnnth---vgrQ-------------------- 93
gi 573990091  22 GTWRHPRLNEITRRReATTfsEKNIRRIAYNTLALLSLWAIRAVVKLYIspqryrpppllpq------------------ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588833  272 -ISS--------------TKESD-------------------------SqlynyshnnhmiipqssssssisvSNTSTIA 311
gi 74610728  141 -VRKnwlqtdqilallhmPNNKA-------------------------A------------------------ENAIDLL 170
gi 74695979  183 -IYQslshffyanvvfklNPHAR-------------------------L------------------------DSGWFRF 212
gi 366992904 206 wLTK--------------LFNNS-------------------------Y------------------------FRSMFLW 222
gi 403218536 137 -QCM--------------QTLWS-------------------------L------------------------QRAHPRW 152
gi 410083451 195 -FYS--------------NVIQSclnnfwnvdgmkkiyffwikvnynyF------------------------NNKLSFH 235
gi 401624711  94 -FCSwlsrthlyllnfhaVKQIN-------------------------Ii-----------------------YYSMFSW 124
gi 401841684  94 -FCNrlsrihlylltfhaVKQVN-------------------------Ii-----------------------YYSTFSW 124
gi 365764305  94 -FCNrlsrihlymltfhtLKKAN-------------------------Ii-----------------------YHTTFSW 124
gi 573990091  84 ------------------------------------------------------------pgnnksadrcpkhSFSPAAR 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74588833  312 ------------FYFVLITKLIIGYFIISIIIAGFKLLKGq--DQCYDLPLTIHQRKLLGLKVNdvpe-----dyiiDEK 372
gi 74610728  171 ------------FSVSSFNKAFRGLVLYNVLMSIFALVGK---VKISDLKLNQRQKNLLGFIGQ-------------GET 222
gi 74695979  213 ------------WTLENISHLIHMLLLINIALSLYMLLVKaqhITVGDLGLNERQKELLGVSASsd----------tRNS 270
gi 366992904 223 ------------ITWDHVEHLVHIIVALNVIISIWKLFTK---VKTNDLNLTPKQKTLLGIDDEmskmnlptrlvgiSSD 287
gi 403218536 153 gplwqlfqdasvVKADYLNHLVGIVLGFNIVTALFKL-RSr--INTRDLELTQRQRELLGLDPRnh---------pqGDT 220
gi 410083451 236 ------------LTAEHLIHGFYLLVAYNIILSMWKLFMT---INMNDINLNEKQRTLLGLNAAsi----------tQQN 290
gi 401624711 125 ------------LTAELVDYLFQLMISLNILFSLWKLLST---VKVNDLNLSKRQMKLLGVDTQs-----------sVDN 178
gi 401841684 125 ------------LTAELVDYLFQLAISLNILFSLWKLLST---VNVSDLNLTRKQRRLLGVDIQp-----------lVND 178
gi 365764305 125 ------------LNAELLDYLFHLLISLNILFSLWKLLST---VKVSDLNLTDRQKKLLGVDMQs-----------sVDT 178
gi 573990091 104 ------------LYMSWAWTVVQIVPLAQIALACTPLLRAr--DEMTDIPLTAAQRKLLGLAPAtasp-----vaaaATA 164
                        250
                 ....*....|.
gi 74588833  373 AEMILKQRRYD 383
gi 74610728  223 SNLRRIEPSNL 233
gi 74695979  271 IIEDVTNPRPl 281
gi 366992904 288 NKRRIEKPHvi 298
gi 403218536 221 KGGHITKPHVV 231
gi 410083451 291 HATPIMKPHiv 301
gi 401624711 179 GVQPQQQPHYV 189
gi 401841684 179 GLQP-QQPHYV 188
gi 365764305 179 GLQP-QHPHYV 188
gi 573990091 165 DLVFSTPPRYS 175
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