Conserved Protein Domain Family
Cm_res_leader

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pfam08077: Cm_res_leader 
Chloramphenicol resistance gene leader peptide
This family consists of chloramphenicol (Cm) resistance gene leader peptides. Inducible resistance to Cm in both Gram positive and Gram negative bacteria is controlled by translation attenuation. In translation attenuation, the ribosome-binding-site (RBS) for the resistance determinant is sequestered in a secondary structure domain within the mRNA. Preceding the secondary structure is a short, translated ORF termed the leader. Ribosome stalling in the leader causes the destabilization of the downstream secondary structure, allowing initiation of translation of the Cm resistance gene.
Statistics
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PSSM-Id: 71513
View PSSM: pfam08077
Aligned: 2 rows
Threshold Bit Score: 1e+06
Threshold Setting Gi: 2708771
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10
                ....*....|....*..
gi 2708771    1 MSGVPGALAVVTRRTIS 17
1_pfamImport  1 MSGVPGALAVVTRRTIS 17
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