Conserved Protein Domain Family
NUC194

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pfam08163: NUC194 
NUC194 domain
This is domain B in the catalytic subunit of DNA-dependent protein kinases.
Statistics
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PSSM-Id: 336943
View PSSM: pfam08163
Aligned: 33 rows
Threshold Bit Score: 268.808
Threshold Setting Gi: 674587886
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1692 VRIALGNKLLIPLLS--NSNLLLE-FYSEFTPYLLQQLNVtwdd--nwkNMLFQ----------LQWRGLIFDLFGIAYK 1756
gi 122086252  1981 LKITLIDKFCVPLIShmKENILVQ-IFSQHLSSLMSIIQPlqp---kylSDSQErk------ssIIEKICCFHLIEALYQ 2050
gi 281205465  1821 LKITLIDKFCVPLIGhmKQQVLIQ-LFAQHLSSLMSIIQPlap---kylATAIErk------ssVVEKICCFKLTQQFYE 1890
gi 470236802   796 LKITLVDKFCTPLIAkmTQPSLIH-LFTLHLTSLMSIIQPlvp---kymTNSGErk------ssIIEKICCFHVIEAFYE 865
gi 675847400    23 hRKSIFYKIFYPTLEsaTEEALLEdYFIAHVLDIMSTLNKkip---yhlDVKLDs--------hFLNKICCLDLITLFYS 91
gi 290995959  1956 IRRQIIQWVCLTCLThmPERGLVQ-FFEDNIQKLMKSIAKptalsetisNPNIEeleadsvralFVTRTCCYNLLEAMYR 2034
gi 168026410  1860 LRRAVVEVIFEAFVNssSMEFVTV-WYSQHISDLFYVLKQsssm--lsaEREFEd---------LFKKICHYELLELLYS 1927
gi 1028700354 1671 rREMISNIFLIPIMSccRKNVITK-IYTDIIDFILKTVNEnll---andSGKARh--------lLISKIACFKLIEEMFK 1738
gi 307207346  1308 eKLDILHEFLLPAFDhcDAPTTER-FFERNIRELHAISRRnis---dsiNSELD----------LVSKIGCYQLMAIMCT 1373
gi 511008424  1808 ihkkNITKVLLVLLKgaNEGHVIA-FFKEHLGYILGVVSQp-------vDRDTDsl------ddLHMKANCLCFMQAYCN 1873
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1757 RMSTEQIKK-------QLHQNLKf--------QADNEITKKLIVDCNKASKfkfekinilninqkeilSQ---VNY--LK 1816
gi 122086252  2051 SLPSAIIKE-------KINPFFYdk-----pdGKGTELTAAIMKAAHSAKSekl-----------tsdDK---YVT--RS 2102
gi 281205465  1891 SLPATVIRD-------QVNPYFTgdk----hdAKGTELTAAIMKAAHLAKSekl-----------atdEQ---HVT--RV 1943
gi 470236802   866 AMPSTTIKD-------NVNRYFYdk-----pdAKGTELTAAIMRAAHSAKSekl-----------asdDK---HVT--RP 917
gi 675847400    92 RLSKDSLHSlt----sKVNSEYCkhfc--vtdIKGKELTTSIIRTAKDFKSddyhski----nshkttPS---SPLddFE 158
gi 290995959  2035 LLPASAVKE-------YINNKYCekqssgsgqLTGKELTEKVMRSSFAARSwk-------------psDQeykVLG--YE 2092
gi 168026410  1928 KADNVSITK-------TIAPVFT-----------SSDLMRQAGDTCHGKLDpe-------------ykLY---PEN--LS 1971
gi 1028700354 1739 FFTNIELNDg-----cTIPYTYIg--------sQSKNLITQFRTSAVKVRYsnvd----------ytkGS---NKI--KH 1790
gi 307207346  1374 RLEESKIVDan----gTIVRNAGld-----nvQDGRELVQSLFKDALNVRKlk---------------iQ---IRC--RD 1424
gi 511008424  1874 LIPTEVIGHggeldnvWVNCKENkg-----htAVRQEMSK-VMKGLHAAIKhdi------------trLT---PER--RE 1930
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1817 IVEDYQSSAFITYIYVLMKTQTKENIFYAHLFKKERDIS--Y--WDNFINKEWQF-NFQVETNFE---EKPLYTEVKKqQ 1888
gi 122086252  2103 LCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNeyL--WENIIDTDQVF-NFQPETNFLv-sYSTPQSLFAN-D 2177
gi 281205465  1944 LATKYHGAAYSALASVVATTQTKETFFHVFFFKENKEKN--EylWENIIDLEQQY-NFEPETNFq--iSSQLSSAV---- 2014
gi 470236802   918 LCTLYHGSAYSCLASVIAATQSRENFFHTFFFKENIEKN--EylWENIIDTEKVY-NFEPETNFTv-nSKVDMNSIARrn 993
gi 675847400   159 MQRLLNCSSFNTLSHVLMRTQTDVKFYTAFLFTENLAKG--EiiWENLIDTKRLY-KFSIEITDAe-aRKMKYKTLRKqI 234
gi 290995959  2093 LLLDFRTSAFNVLAGGVKCTQTQEKFYTGFLFKE---KE--EdlWENIIDTNREY-KFEIETNFAf-hRK-AVDELRIdS 2164
gi 168026410  1972 TWRELHAAAYNCLAAVILCTQIDEKWFNAFLFSE---KS--RplWQHLVDLTKVYdDMSVETSQSs-iISQTVKGMRAdL 2045
gi 1028700354 1791 LFRQLHCSSYNALITIISNTEDDHNKYTIFLFNERPPK---QfiWRNLVDCTIRY-EFPIDFEKVp-qRKKKLINIRTkS 1865
gi 307207346  1425 IVRLLHCSAYNLTLAITS-LKEDEQFYN-IVFAENRDRG--MfiWKNIIDCEKHY-QLSQICGNSkshCRETTVNIKSsV 1499
gi 511008424  1931 AIINFHREAVNAFGTFVMRVVNKEKLYEAVF---RMGST--DfiWDALIDPEE---PIYLDMLFAqplLKKKLDAFFNsK 2002
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1889 ----Q----DY-----------F-------------------------Qek-----------------ivKN-YLYTASL 1906
gi 122086252  2178 ----L----RY-----------L-------------------------S---------------------SQ-YLVDSSL 2191
gi 281205465  2015 ----------------------Ansq-------------------srdLky-----------------lsSQ-YLQDSSL 2035
gi 470236802   994 l---------------------------------------------qdIky-----------------lsSQ-YLQDSSL 1010
gi 675847400   235 ----R----IHtqgkpgvdaedEeed-------------------ndnVqy---------------------lsTLDSSV 266
gi 290995959  2165 ----N----QPtsd-----ngkRkag-------------------elrIgylssqylsdsslsssmpfagSF-FIPGSKY 2211
gi 168026410  2046 ----KarrtRG-----------Kgsl-------------------sqtAst-----------------isSQ-YMHSASL 2073
gi 1028700354 1866 ----N----QN-----------IpevyidlsshlkntlvedlgsydynNsy-----------------lrSN-FVEDCSS 1908
gi 307207346  1500 idggR----EG-----------Qass-------------------qhrYsh-----------------ihSY-DLLTCSL 1527
gi 511008424  2003 ----E----RKn----------Nkae-------------------rpsIyy-----------------mdSIdIMGSRYL 2028
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1907 --SVE-------QVtETTmeieeenENLQS------------------T------------------------------- 1928
gi 122086252  2192 --SQDfiaknflEGdNNS-------TTNNNngddgiimqgqsqsgdneN------------------------------- 2231
gi 281205465  2036 --SQS-------------------------------------------L------------------------------- 2039
gi 470236802  1011 --SQD-------------------------------------------A------------------------------- 1014
gi 675847400   267 --SADltqlipksn-------------------------hfsvnksvpH------------------------------- 288
gi 290995959  2212 --SEE-------------------------------------------Vtkssedesk---------------------- 2224
gi 168026410  2074 --SQE-------------------------------------------Pavirtfvggirkeetsaagvgagllldeesp 2108
gi 1028700354 1909 pnSQSl-----------------------------------------hK------------------------------- 1916
gi 307207346  1528 --NEEinaydfnksvll--------------------pasaaipcgrsA------------------------------- 1554
gi 511008424  2029 --EED-------------------------------------------I------------------------------- 2032
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1929 -----------------V---------------------------------E---------------------------- 1930
gi 122086252  2232 -----------------Q---------------------------------I---------------------------- 2233
gi 281205465  2040 -----------------Dvdtsssttststtt------tsnnnnlkivasaM---------------------------- 2068
gi 470236802  1015 -----------------S---------------------------------Isgrgafiapapvghplatfddimyqqqq 1044
gi 675847400   289 -----------------Q---------------------------------S---------------------------- 290
gi 290995959  2225 ---------esektpnvD---------------------------------N---------------------------- 2234
gi 168026410  2109 stetnietaeqepaeeiI---------------------------------E---------------------------- 2127
gi 1028700354 1917 -----------------M---------------------------------F---------------------------- 1918
gi 307207346  1555 -----------------T---------------------------------I---------------------------- 1556
gi 511008424  2033 -----------------DmegnatieanqtgntdntnstndtnntnntnstE---------------------------- 2067
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1931 ------VQKIEMDEVNKHKLMIPMLSLIDFMANKQNFQQQIAGQQqtqqtq--qqeeeMPSWMTAIKQVFNDd-S-LY-- 1998
gi 122086252  2234 ------SNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFgqqsqqpkptvgdMPKWMFEIYQKLQQ--G-VH-- 2302
gi 281205465  2069 ------NMPIELDKINSNPSMQPMLKIIDIYQERFRESIDQSpn-------------dMPKWMNELYLKVKNd-TnLH-- 2126
gi 470236802  1045 rkyaklNENMEMDEINSNPSMLPMLHIIDIYQDKFKLDSNSn---------------eMPKWMTELYNKAKDs------- 1102
gi 675847400   291 ------TPTLDFDEMNCHESMQTLMTIIHHINENIAPFQSSPTSAa------------aPTWLSCIIEKISSp-S-TR-- 348
gi 290995959  2235 ------SSTLEMDEVNTNPCMASILRTVDHMVSIFKYPVGSDKAAan---------saMPSWMAEMHKKLNNd-E-TH-- 2295
gi 168026410  2128 ------TTALDRDDFDQHECMPVILRLAEHVHVKFGANYQpg---------------vMPDWMKSLHATLDNa-A-TH-- 2182
gi 1028700354 1919 ------SVELEMDSFNNHECMAHLCAVIKYLSSENMIGSAMKPNVd------------MPDWMNNLKLVFCDkaT-DT-- 1977
gi 307207346  1557 ------NVILESDDFNEHECMPNICGILQRFSSLKKPEKMTK----------------LAECLNYFVLGLQKd---VP-- 1609
gi 511008424  2068 ------DINLEIDQLNDNSFMPVFTEMIKKLSEFQDKKQDNDMEIdne-------nkpMPSWMVGLRYAFNHy-Q-TPqy 2132
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1999 ----LSLKIFMLKLIINKS-DIFNRYASGWIGVLLDYCTKENKinG--------GKG--FHYFLRDVIVVLIKFSQKLEV 2063
gi 122086252  2303 ----PNIVIFMIKIIINRP-QYFERFHELWIPILMDYVVSEGN--G--------GNG--LHYFVRDVCFILLKWPNIYKS 2365
gi 281205465  2127 ----PNILIFILKVIINRQ-QYFYRYHKQWTPILIEYVISNQT--G--------GQG--IHYFIRDIAMLLLSWPNIYQD 2189
gi 470236802  1103 -------------LLINRP-QYFEKYHRQWIPLLIDYVISPAT--G--------GKG--FHYFIRDVCLIILKWPNIYsl 1156
gi 675847400   349 ----WNVVIFLVKVIVNCQ-QILKYFASFLIGPLLKVAQDCRL--Y--------EHG--SNTISNDVVVMLLLWSDAAKP 411
gi 290995959  2296 ----RNIKLFLCKIITNRP-TIFEPFSKYFFEPIIKFIMKEED--DqkknedlsSKG--ITYFIRDLIILLLKWKDVSps 2366
gi 168026410  2183 ----INVRLFLAKVITKTR-KIFAPHAADWIRPYVQTILIDPR--K--------SGGlkFHYMLRDICVTILQWNVASAP 2247
gi 1028700354 1978 ----INSKILLIKLIINCE-TNFEPYAKHWLCPLMEFVLDKHL-----------GNN--LNYVITDVVSMLVSWHNIAVP 2039
gi 307207346  1610 ----RNIQLFMLKIVDNTAnTVFKPYAKFMLPGIAQAVANY-L--K--------AND--LNYIITNVLNILISWRDKIND 1672
gi 511008424  2133 dkakYTRQVYIARLIVNYP-QAFENYAHEWIVPLLKFVVKGHL--F--------GET--MNYLVHDICIILGVWGETTFN 2199
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