Conserved Protein Domain Family
NUC194

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pfam08163: NUC194 
NUC194 domain
This is domain B in the catalytic subunit of DNA-dependent protein kinases.
Statistics
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PSSM-Id: 311886
View PSSM: pfam08163
Aligned: 34 rows
Threshold Bit Score: 276.504
Threshold Setting Gi: 124446673
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1692 VRIALGNKLLIPLLS--NSNLLLEFYSEFTPYLLQQLNVtwddnwkNMLFQ----LQWRGLIFDLFGIAYKRMSTEQIKK 1765
gi 122086252  1981 LKITLIDKFCVPLIShmKENILVQIFSQHLSSLMSIIQPlqp-kylSDSQErkssIIEKICCFHLIEALYQSLPSAIIKE 2059
gi 470236802   796 LKITLVDKFCTPLIAkmTQPSLIHLFTLHLTSLMSIIQPlvp-kymTNSGErkssIIEKICCFHVIEAFYEAMPSTTIKD 874
gi 281205465  1821 LKITLIDKFCVPLIGhmKQQVLIQLFAQHLSSLMSIIQPlap-kylATAIErkssVVEKICCFKLTQQFYESLPATVIRD 1899
gi 514698054  1698 VRRGVAQRVLATFLQacKLSMCSAFYIKRLPAIMSLMSQdtp-ltsTPA------IVIKMCTFTLIDILFQRLNTTDLYG 1770
gi 168026410  1860 LRRAVVEVIFEAFVNssSMEFVTVWYSQHISDLFYVLKQsssmlsaEREFEd---LFKKICHYELLELLYSKADNVSITK 1936
gi 1028700354 1671 rREMISNIFLIPIMSccRKNVITKIYTDIIDFILKTVNEnll-andSGKARh--lLISKIACFKLIEEMFKFFTNIELND 1747
gi 167538125  1308 aRNALAHHVLPALLEgcDAAVRRDFYREEITAITAMLSSkh-------hsDt--aGWSREVACQLLAQMFRLLPVHEVYG 1378
gi 511008424  1808 ihkkNITKVLLVLLKgaNEGHVIAFFKEHLGYILGVVSQp-----vDRDTDslddLHMKANCLCFMQAYCNLIPTEVIGH 1882
gi 674587886  1658 lwlryVHKFLKPLLLsvSPSALERLAAQSITKWMQTLEDnasedasHVITQwlwrLLNRALTFYLLVTIYNRLPKAVLHG 1737
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1766 -------QLHQNLKf-----------QADNEITKKLIVDCNKASKfkfekinilninqkeilSQVNYLKIVEDYQSSAFI 1827
gi 122086252  2060 -------KINPFFYdk--------pdGKGTELTAAIMKAAHSAKSekl-----------tsdDKYVTRSLCTKYHGAAFS 2113
gi 470236802   875 -------NVNRYFYdk--------pdAKGTELTAAIMRAAHSAKSekl-----------asdDKHVTRPLCTLYHGSAYS 928
gi 281205465  1900 -------QVNPYFTgdk-------hdAKGTELTAAIMKAAHLAKSekl-----------atdEQHVTRVLATKYHGAAYS 1954
gi 514698054  1771 ks----aVINKTYCeaag----epvnDKGSNLTTNTCRALRDTVT-----------------GEESLVELRRQASCAAYN 1825
gi 168026410  1937 -------TIAPVFT--------------SSDLMRQAGDTCHGKLDpe-------------ykLYPENLSTWRELHAAAYN 1982
gi 1028700354 1748 g-----cTIPYTYIg-----------sQSKNLITQFRTSAVKVRYsnvd----------ytkGSNKIKHLFRQLHCSSYN 1801
gi 167538125  1379 tr----aAVNQAFHdqag----ltgaVADNCLTKAVVDSLRGFLQdk-------------ttQIPGLTNFPQTLKQKAFN 1437
gi 511008424  1883 ggeldnvWVNCKENkg--------htAVRQEMSK-VMKGLHAAIKhdi------------trLTPERREAIINFHREAVN 1941
gi 674587886  1738 ltaggvgSVLRAFLgpskldliqsgkIKGTELTAAIIKKACSTLQdqlnprf---napltdeLESIAKSLKQTVWSASLA 1814
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1828 TYIYVLMKTQTK----ENIF---------------YAHLFKKERDIS--YWDN-FINKEWQFN-FQVETNFE---EKPLY 1881
gi 122086252  2114 ALASVIVSTQTK----ENFF---------------HVFFFKENKDKNeyLWEN-IIDTDQVFN-FQPETNFLv-sYSTPQ 2171
gi 470236802   929 CLASVIAATQSR----ENFF---------------HTFFFKENIEKNeyLWEN-IIDTEKVYN-FEPETNFTv-nSKVDM 986
gi 281205465  1955 ALASVVATTQTK----ETFF---------------HVFFFKENKEKNeyLWEN-IIDLEQQYN-FEPETNFQ-------- 2005
gi 514698054  1826 ALTTVICKTQTQ----EKFY---------------SAFCFKEATGKVrdCVFN-LIDEKRKYT-FTTELPAAmsvRSKCV 1884
gi 168026410  1983 CLAAVILCTQID----EKWF---------------NAFLFSE---KSrpLWQH-LVDLTKVYDdMSVETSQSs-iISQTV 2038
gi 1028700354 1802 ALITIISNTEDD----HNKY---------------TIFLFNERPPKq-fIWRN-LVDCTIRYE-FPIDFEKVp-qRKKKL 1858
gi 167538125  1438 TLFHVLDCTQTDpakrLKFF---------------TTLCFESKKGPSpiVCVApTAD--ETFE-FKAELDQAptlRLRQL 1499
gi 511008424  1942 AFGTFVMRVVNK----EKLY---------------EAVF---RMGSTdfIWDA-LIDPEE--P-IYLDMLFAqplLKKKL 1995
gi 674587886  1815 CLIAAINATQTQ----ERAYshillgdsltrflpnTSFIFPRRRSRK--YRSA-FIELREQFW-LPSEREPYfgkIDVKS 1886
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1882 TEVKKq--------------Q---------QDYFQekivKN-YLYTASLSVE--------------------QVtETTme 1917
gi 122086252  2172 SLFAN---------------D---------LRYLS----SQ-YLVDSSLSQDfiak-------------nflEGdNNS-- 2207
gi 470236802   987 NSIARrn-----------lqD---------IKYLS----SQ-YLQDSSLSQDas-------------------isGRGaf 1022
gi 281205465  2006 --ISSqlssav---ansqsrD---------LKYLS----SQ-YLQDSSLSQSldvdt----------------------- 2043
gi 514698054  1885 LALREgeatpst-taaataaA---------RRYLP----SQ-ILADSSLSQDaaqlealrqgadvgesqaveDA-SSSss 1948
gi 168026410  2039 KGMRAdlkarrtrgkgslsqT---------ASTIS----SQ-YMHSASLSQEpavirtfvg---girkeetsAA-GVGag 2100
gi 1028700354 1859 INIRTksnq------------------nipeVYID----LS-SHLKNTLVEDlg----------------syDY-NNSyl 1898
gi 167538125  1500 TALRSsar---------tqhG---------TRYLT----SQ-LLADSSLSQSmas---------------waDP-NGAss 1540
gi 511008424  1996 DAFFNskerkn---nkaerpS---------IYYMD----SIdIMGSRYLEEDi-------------------DM-EGNat 2039
gi 674587886  1887 QDMDSslqqkn----ksgglLlgsslsleiNRFMRas-gTQ-IIRGSTss---------------------tDF-KKPls 1938
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1918 ie-eenENLQS----------------------------------------TV--EVQKIEMDEVNKHKLMIPMLSLIDF 1954
gi 122086252  2208 ------TTNNNngddgiimq----------------------gqsqsgdneNQ--ISNDIEIDQVNSNPSMIAMLKIIDF 2257
gi 470236802  1023 ia-papVGHPLatfddimy-------------------------qqqqrkyAK--LNENMEMDEINSNPSMLPMLHIIDI 1074
gi 281205465  2044 --ssstTSTSTtttsnnn---------------------------nlkivaSA--MNMPIELDKINSNPSMQPMLKIIDI 2092
gi 514698054  1949 sp-pssDGPTFgldmdaseds--------------------pgapsnipvyVV--EDSQMEMDELNSHESMVSLMGLIQR 2005
gi 168026410  2101 ll-ldeESPSTetnieta--------------------------eqepaeeII--ETTALDRDDFDQHECMPVILRLAEH 2151
gi 1028700354 1899 rsnfveDCSSPnsq----------------------------------slhKM--FSVELEMDSFNNHECMAHLCAVIKY 1942
gi 167538125  1541 le-aapVPGAEaagaeveppkpteaknlpepmdleldddgidedrqagstlTL--SGTQLELDALNRHPNMLTMLALVEQ 1617
gi 511008424  2040 ie-anqTGNTDntnstnd---------------------------tnntnnTNstEDINLEIDQLNDNSFMPVFTEMIKK 2091
gi 674587886  1939 pg-vspPLSQTspdfrq----------------------------lekveaEP--NYVNLEVDPLNMTSLMIAFVGLLKR 1987
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124446673  1955 MANKQN-----------------FQQQIAGQQQ------Tqqtqq--qeeeMPSWMTAIKQVF-NDd-SLY------LSL 2001
gi 122086252  2258 YQKKFV-----------------VTPPSSILFG------QqsqqpkptvgdMPKWMFEIYQKL-QQ--GVH------PNI 2305
gi 470236802  1075 YQDKFK-----------------LDSNSN----------E-----------MPKWMTELYNKA-KDs------------- 1102
gi 281205465  2093 YQERFR-----------------ESIDQSPND-------------------MPKWMNELYLKVkNDt-NLH------PNI 2129
gi 514698054  2006 IQAVHA-----------------ESKPQRNEDGlilpssT-----------MPSWMSNLLKSF-ESt-STS------HNV 2049
gi 168026410  2152 VHVKFG-----------------ANYQPGV---------------------MPDWMKSLHATL-DNa-ATH------INV 2185
gi 1028700354 1943 LSSENM-----------------IGSAMKPNVD------------------MPDWMNNLKLVF-CDkaTDT------INS 1980
gi 167538125  1618 MLVSMSraadesgsaaasalrsaEEAPAIPAAE------T-----------LPAWMSELLSIV-NAa-HVH------MNQ 1672
gi 511008424  2092 LSEFQD-----------------KKQDNDMEID------Nen-------kpMPSWMVGLRYAF-NHy-QTPqydkakYTR 2139
gi 674587886  1988 MSQLGL-----------------LKPNE-----------------------MPQIIKFLYDQF-NTn-QEN------CNV 2019
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124446673  2002 KIFMLKLIINKSDIFNRYASGWIGVLLDYCTK-ENki-nGGKG--FHYFLRDVIVVLIKFSQKLEV 2063
gi 122086252  2306 VIFMIKIIINRPQYFERFHELWIPILMDYVVS-EGn---GGNG--LHYFVRDVCFILLKWPNIYKS 2365
gi 470236802  1103 ------LLINRPQYFEKYHRQWIPLLIDYVIS-PAt---GGKG--FHYFIRDVCLIILKWPNIYsl 1156
gi 281205465  2130 LIFILKVIINRQQYFYRYHKQWTPILIEYVIS-NQt---GGQG--IHYFIRDIAMLLLSWPNIYQD 2189
gi 514698054  2050 RLFIAKLITNMPDAFQPWSSRWLRPIMLLILK-FQde-pETPG--FNYFVTDLCLLLLTWADTAVP 2111
gi 168026410  2186 RLFLAKVITKTRKIFAPHAADWIRPYVQTILI-DPr---KSGGlkFHYMLRDICVTILQWNVASAP 2247
gi 1028700354 1981 KILLIKLIINCETNFEPYAKHWLCPLMEFVLD-KHl----GNN--LNYVITDVVSMLVSWHNIAVP 2039
gi 167538125  1673 KLFIAKVIINQPQHFQPWAKWWLAPLMRMAVAlGDr---QAEP--FNYFVTDLCVVLLRWSETAVP 1733
gi 511008424  2140 QVYIARLIVNYPQAFENYAHEWIVPLLKFVVK-GHl---FGET--MNYLVHDICIILGVWGETTFN 2199
gi 674587886  2020 QVFVVRLVINCPEVFKPFYRRWLPLLLTYASS-STeallDSSG--LSSLAIELCLLLADWSRSNIl 2082
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