Conserved Protein Domain Family
Mad3_BUB1_II

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pfam08171: Mad3_BUB1_II 
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Mad3/BUB1 homology region 2
This domain is found in checkpoint proteins which are involved in cell division. This region has been shown to be necessary and sufficient for the binding of MAD3 to BUB3 in Saccharomyces cerevisiae. This domain is present in BUB1 which also binds BUB3.
Statistics
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PSSM-Id: 311892
View PSSM: pfam08171
Aligned: 20 rows
Threshold Bit Score: 70.7397
Threshold Setting Gi: 74610036
Created: 19-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4BL0_E          7 KTSIYAD----------------------QKQSNNP--VYKLIN---TPGRKPERIVFNFNLIYPENDe---EFNTEEIL 56
gi 74610036   304 KMILFQD----------------------NLGRSEP--VYKLIK---NNSGKLEKIDYNTNLLIYEGR----EICLEEIL 352
gi 74688457   298 KITVFKDvahdtdg--------avpiqtiEEDENGL--MHTLIR---HPGKNQEKVSLNMDLLYPEQGd---EYCLDEIL 361
gi 74586995   311 KIQVFRDfeplaf----------qakksiCYDEKGR--AYTLIE---NPGKKSERVLVNMDLIYPDESq---EFSMLELL 372
gi 401625562  289 KIPIFAD----------------------SKQSSGP--VYKLIN---TPGRKLEKIAVNFGLIYPRDDe---EINIEELL 338
gi 366987761  292 KLPVFTDnii----------------eenNKTSTLPkkVHKIIE---VSGRKPEQVDCNFDLLYVNDDq---EFCIEEIL 349
gi 403216133  226 KLPIFKDaeddephmlrvntnleplssikEGERENP--IYKIVK---LPNRKPERIDCNFNLLYTQNGe---EFSIEQIL 297
gi 296418762  318 KMMIFRDes-------------------sLPKQNVPpvQQNVLPtylPSNKRPERVAVNLELIYADEEnpteELSFDELR 378
gi 410084004  241 KLNVFNDnnndnnnnni---nsntttnnnNNNDNIP--VYKIVN---IENRKPEKIDCNFDLIYNSS-----EFNFDQIL 307
gi 302503667  330 KMTVFKDet-------------------iNVSRNNK----ERVD---PRTGKIERVVVNLEAIYPDSHnpavEMSLDELR 383
                          90
                  ....*....|....*...
4BL0_E         57 AMIKGLy------kVQRR 68
gi 74610036   353 TMMKSN--------TQNN 362
gi 74688457   362 ALTRKLskvslgyeEQQN 379
gi 74586995   373 AISRRS---------ERQ 381
gi 401625562  339 AISRGFy------eRQRR 350
gi 366987761  350 ALSRGLy------yKTRe 361
gi 403216133  298 AKKRDLy------dKRST 309
gi 296418762  379 AIKRGQy------gIDWN 390
gi 410084004  308 ALSRNVy------hKNNY 319
gi 302503667  384 AIRRGWm------sKDWS 395
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