Conserved Protein Domain Family
PIH1

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pfam08190: PIH1 
pre-RNA processing PIH1/Nop17
This domain is involved in pre-rRNA processing. It has has been shown to be required either for nucleolar retention or correct assembly of the box C/D snoRNP in Saccharomyces cerevisiae. The C-terminal region of this family has similarity to the CS domain pfam04969.
Statistics
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PSSM-Id: 311900
View PSSM: pfam08190
Aligned: 15 rows
Threshold Bit Score: 315.474
Threshold Setting Gi: 124459564
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122043651  46 LRDIQMRiqeesrNAMKSKLEAIQSDEN-GQ-WMYVLPEPGFCVKCTTSGG-G---KIFLNVCQHERIAEPipmeeDEKT 119
gi 124459564  44 ISDPKNR------EEYDQYLKQLERESElPKgMKLIKPEPHFCVKTSICKEiTlqfKFFINICSTSVIDKP-----QSET 112
gi 122100766  46 LADLQKKiqeesmKSAKAKLEEIHSDEN-GQ-WMYILPEPGFCVKCKVAGG-G---KVFVNVCKHERIAEPipiddDNEA 119
gi 74948115   30 INQYFGG------ADPEGS-GPQQKPPP-RD-SLIVQPTAGICVKSFKTNS-De--KFFINVCQAAEVPAPqdvteEELI 97
gi 122106425  23 VRDETEEqf---nSMFGPIVEQAQDISS-GR-SKVVKPTPGFCIKAFRKDT-Rn--KFFINVCQTDGIPAPediteDQLM 94
gi 224493179  50 VQDPENR------KIYEQEITQLEKERG-VD-IKFVHPKPGFVVKTSIDGE-L---KCFINIASSPEVARPn---sEVGM 114
gi 224493093  36 LRD--NR------KQYEDELSMLEAQRG-YD-VKFLKPSPGYVIKTIVDGK-G---KGFINVCQSELVQKPt---sTTGL 98
gi 122091752  38 LKDPENR------KQYEEELKLMEAERG-YD-VKFIKPLPGYVIKTVVDGK-T---KAFVNVCHCDLVGKPs---sQCST 102
gi 47230099   40 LADPENR------RRYEEEIKILEQNRG-NT-IEFIHPEPVKALRTCMNGS-Q---KCYINICASEKIGKPs---cSPKV 104
gi 156374986  38 ISDPENK------KRYEEEIRQMENERG-MD-VKFVNPEEGFVVKTTRETD-Gi--KAFVNICYNQHIEKAtfrmaEKGD 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122043651 120 D------EIKFKIPLSCGQARPGTDKSGKPCKVYDVIVNPSTVQRCSKDHEFRCFVVSLCIHWIKQKC---EPTLNhEEY 190
gi 124459564 113 ItqngqtGQNWKIPYSIGKIRYDQDKKQNICNTVDVAFHPTTIGLCYKTPNFKNLVCSTALEASGKQLgerNEEIS-KDF 191
gi 122100766 120 -------EVKFRIPLSCGQARAESDKSGKPCKVYDVIVNPSTIHRCTQDHDFRCFVISLCIHWIQQKS---EPTLNlQEY 189
gi 74948115   98 GilesttPGSYRVPMSISDPRFTKDRSDKTVDVCDIAINPKFLVKIQKSQLFKNFFMQIVIEAMSEKY---NVQLNmEKT 174
gi 122106425  95 AilndgtPSSFKIPMSITQPRFMKDHLDKQCQVCDIAVNSTFFKKIESGGLMRDFLITIVLEGIDSKY---NIALDeTDW 171
gi 224493179 115 NpetggrGLSWSIPMAQTGGRDDCDAKNNHCKVFDVVFHPDALHLSTRDSQFRKALIDTALDAVEREY---EVALDrANL 191
gi 224493093  99 Nedg-tkGLKWSVPYAQTQPRKDYDNKRVECTVYDVMFHPDALHLASKNEGFRKLLNDTSLDAVEQSF---KVRLDrANL 174
gi 122091752 103 Nkrg-ekGLKWSIPYAQSQPRKDYDNKNVDCVVYDVVFHYDTLHLTKSNKNFRKLVTDTALDAVEGAF---HVSLDrVNL 178
gi 47230099  105 Ledg-rgTLCWALPHILHPKKQELYRKGHKVTIYDVVFHPETLDLASKNKTFLDMVHDTAIQGIQSAF---SVSLDrNGV 180
gi 156374986 107 Gter-kkGQQWSIPYSLAQPRDDFDRAGKKCVTFDVVFHPDTYKKCTKMPQFKKMVIETALEGIERQL---NIKLNkKNL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122043651 191 RSM-NFKVKG-DLEPQRIRLSTAPKGANAMGdeirlpkDNSAALPPTTVGGRGGTGKLIQEVtnpa----iasdAVSSPQ 264
gi 124459564 192 KVLkHTKCKGgEPALLPVRIDKKGKLTNELD-------SRQGGQANAQTKLQKDINQMRDENekikeeeklkqqQQKEQQ 264
gi 122100766 190 RNM-SFRVKG-TLEPQRIRLSTTPKVANALGdeirlpaNATAASPVTNVGGRSGTGKLVQEI------------TDAPAP 255
gi 74948115  175 IILnNRKFIG-TLVTHRVRNEDMKRAQSTSgi-----pAALN-SRDGGAVAPENSGKLVQEI------------DEKDAA 235
gi 122106425 172 RVLkNKKFVD-KLTAHNIQNRDVKTVLESYKyptesdlSKIKELETPQLGIDKPKKKLIEEI------------DPVTIK 238
gi 224493179 192 KYP-KLDYKG-IARPTVIRKLAANPTPEEQEphp--leHMYPTKPPASNSEPK--------------------------- 240
gi 224493093 175 RFP-KLQYKG-TPSSSVVREKLPHCDSLPKDel---fdKLLPPLPNVPAPGKTGSERTTKTK--------------NKEN 235
gi 122091752 179 KFP-KLQYKG-VAKMTVIRQKLKNFETRRKDgl---idTLYRASEQSKITHDNSADKEN--------------------- 232
gi 47230099  181 KEI-RAKCKG-TPQTCVIRKPIPGYQEpp-------gkSDLPEFPYPDERRQPTSLQTDPTG------------P----- 234
gi 156374986 183 KFP-KMKFKG-MKQATVIRNKSNENSFKKPNeg---itIGDKTIPYPYADQPTCANK-----------------QAHKSR 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122043651 265 AAVPATSTTTTAAESSA-ASKEERiapslvKLQGEGIYDWSRHVKPvlNPYFRENIPATYAVEVCIPTVTSIAEVEVRIT 343
gi 124459564 265 AEEEEDIKKESDEIESTaVSRPKY------RFIYSYPVEYSDFLDS--RANMSIKLPNQLACDLKMQKVEAMKEIQLDLS 336
gi 122100766 256 AAAPAPPPTVNS------PSPPEEpkpsvmRVESEGIYDWSTHSKPtiNPYFRETVPAAYLVELHIPTVTTIAEVDVRVS 329
gi 74948115  236 AIRKSRQSAGGG------FLDIQY----------------KLRGRV------RDESVDEIHAEIYLPNYVSSQEFSLLVG 287
gi 122106425 239 TMKDVKNKLSGKDEYVPdPTKVAI------SQAASKKPDCRLFREP------ASGRVKTLIGEFYLPECTSAKEITLDIG 306
gi 224493179 241 -----ILPMKTKAAPVPeFAVPKY------SIKQSHDVDLSEYTDEl-DAKLHVTVPRSLVVEIELPLLRSTAECQLDVT 308
gi 224493093 236 INRTAAVAAAAASPGNPfYTTPEY------KIVQCRDVEYGEMTNEl-DAKIDVTIPRELKVVITLPLLKSTAECALDVT 308
gi 122091752 233 -----VNKQTFKSASQLeYTTPAY------KLIHRKEVEYHELTGEl-DAKLDAAIPKELVLVIELPLLKSANQCTLNVT 300
gi 47230099  235 -AVPTRSCAAGPRVQTKePAKPKY------TVRYRSYVDIQDFRRSr-NSA-QSPRPKEIVVTIDVPLLKEVTGARVEAR 305
gi 156374986 241 TPGQITSKVKDNNADTRdPRNPEY------TILHRGIIDFQNFTNAr-DSC-TSTRPKELVIRIDLPDL-ALNHCKYRYS 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 122043651 344 PRSIEISYVDaedgAPFLS---IPLDYPIDEDAPNAKFVRKTHMLKMQLLV 391
gi 124459564 337 NQGLVLDVPN----KYFLD---IKLPYPIEQTEASAKFDAKSKTLKIRAPI 380
gi 122100766 330 PKRIELLYVDcedgVPFLT---VPLGYPIDEELQDAKFVRKTRTLKLKLRV 377
gi 74948115  288 EDRIVVETRKy---GYVFN---KFVNYRLQQDRAQALFDKTTKMLHVRIPV 332
gi 122106425 307 EDRILLEARKk---GYLLD---AFVDYQIDGSRISAQFNTKTKMLNVIMPV 351
gi 224493179 309 AKSVYLLSERlg-aKYRLK---LDLPFVVDDKAGNARFDTEKRRLSITLPV 355
gi 224493093 309 KTTLHLVSEKp--aRYKLE---LKLPYEVKESEGKATFNVEARSLTVTLPV 354
gi 122091752 301 SSEVHLISDSp--aKYKLE---VKLPYTVLEKNGSAKFNTDETTLTVLLPV 346
gi 47230099  306 ERMLLLESEs---pAYRLE---LPLAYPVDEEKGEAKFSKQKGQLTVTLPV 350
gi 156374986 312 AFSRCC--------QFFLDichITLPYPIDENKGSAKFDKSKqqlvvtllv 354
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