Conserved Protein Domain Family
MIS13

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pfam08202: MIS13 
Mis12-Mtw1 protein family
Mis12-Mtw1 is a eukaryotic conserved kinetochore protein that is involved in chromosome segregation.
Statistics
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PSSM-Id: 311907
View PSSM: pfam08202
Aligned: 9 rows
Threshold Bit Score: 237.812
Threshold Setting Gi: 74608578
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74634016  258 LPLKHTPVIqqqd-mrkvPAKTPERNH--DNRGRRISSLGNGF-----EGEPHADVDAQNFYKHFEPG-LPEPHKARLLL 328
gi 74602447  245 MNLEDSDTArtrn--qkaPNGKNKRRAsyHNRGKRVLSIGNGF-----VGVPHEDVPTSDYYKLLDTS-LPEPHRMKQLL 316
gi 74606276  193 NPLSQNRPIla------pEDSRAKRKSfmIQRGRRLSLLNQENql-ndIISPHKDVHESEFYRYMNNS-FAQDLKMKQLM 264
gi 74608578  115 IKVIDNEAAlks---slnERARNKRLSl-SQRGRRLSMLSTGVdr-hvIVSPHKEVPEQEFYKHVGDLsFGKSLQLRQLF 189
gi 74626004   45 LPVSDTPIVkrnkelrkgKG----RRSslDQRGKRASSIGTGF-----EALPHADVPSHEYYRHISKD-LSEPLRIKQLL 114
gi 28201793   78 LHLSPqeqs-----asyqDRRQSWRRAsmKETNRRKS-----------LHPIHQGI--TELSRSISVD-LAESKRLGCLL 138
gi 28201791   76 FHLSPqeqs-----irpqDRRQSWRRAsmKEVNRRKS-----------LAPFHPGI--TELCRSISVK-LAQSQRLGALL 136
gi 85102960  233 LPLSDTPIInrnkemrkkGGASGSRRSslGMRGRRASSLIENGh----SAIPHREVDPSEFYKHIEAEgLSEPRRMRQLL 308
gi 765669264 223 QQLQQPHYI---------QRTRERKKSigSQRGRRLSMLASQAnggstIISPHKDIPEEDFYTVVGNAsFGKNLQIRQLF 293
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74634016  329 TWSGKRAMMNHKtrmvr-------------esapQGLSETDETTARRIVRVIMEDIIRDMKDGKVNTSWYNRPEPDGDDh 395
gi 74602447  317 IWSFKKKLDQEEkls----------------rskSKSETTEDQTIINIAKVIKEEVLRDLIEGQISISWYNRDDNEDET- 379
gi 74606276  265 NWCLIRALRKLE-----------------------IKNSQNKSESRKITLTILKDFVRDIRKGSHDIDWDSEGPEAEPTv 321
gi 74608578  190 NWCCDRTYTRIQeadrk------------ktqsqTLEENGSYGDPKKITMNIIKSFVHDLKKGTLDIDWEAEEEEEEDDy 257
gi 74626004  115 LWASSKALEEQR----------------------KKYGETEEASEAAIARSIVQEVLNELLANKVSVSWYQRP------- 165
gi 28201793  139 LSSFQFSIQKLE----------------------------------PFLRDTKGFSLESFRAKASSLSEELKHFADGLE- 183
gi 28201791  137 LSSFQFSVEKLE----------------------------------PFLKNTKDFSLECFRAKASSLSEELKHFTDRLG- 181
gi 85102960  309 TWCGERALSEKP------------------------PHGSHGSSAILGARAIQDQLLKDFGARSEFSDWFAREEAPKPPv 364
gi 765669264 294 NWCLMRSLHKLElkaknqeeegelehltkkskleSTKAETDYVDPKRLAMVIIKEFVDDLKKDHIAIDWEDEEKYEDEDe 373
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74634016  396 ----------SNSRFTK--------------------------------------------------------------- 402
gi 74602447  380 ----------NDNMLTNkev-----------------------------------------------------------t 390
gi 74606276  322 ---------eDESEISNlfkegntensilvdss---------------------------------lsnknkippiklak 359
gi 74608578  258 sg------ngNDTELNAlfddhndgntrhtsarqnltlyddefditlgiqptrpeleyrnnkknnrqstrkrkiqtphkk 331
gi 74626004  166 ----------PDAVIPNk-------------------------------------------------------------- 173
gi 28201793  184 ----------TDGTLQKcfe----------------------------------------------------------ds 195
gi 28201791  182 ----------NDGTLQKcfve---------------------------------------------------------ds 194
gi 85102960  365 v------------------------------------------------------------------------------l 366
gi 765669264 374 ekildntenyDDTELRQlfqenddddddddevdyseiq----------------------rsrrkfserrkalpkepkkl 431
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74634016  403 -PNAQNIANAEKLALFKKRLAAQQAEIKEWAKLEaEAREr--------LDMAKGKSQKLV-----AQLQKPFDSPPTLps 468
gi 74602447  391 lPNPLNITNEENIEIFTKKLKSLKQERSQWESSFnRSTSh-------iPNLKIDANQKEAdlqdyCQIRSETQDSSVDfn 463
gi 74606276  360 iPNEKNIQNKENAKILEEKIKTIKNEIEQWSKDLsDVKI---------PSYELPKSQTSI-----VKLPDNLQLTATT-- 423
gi 74608578  332 lPNTKNVENEKNLIMLKQKIDILENDINEWANTL-DSHD---------PQKEWQLIKD-------VKPDNTTPEQTIT-- 392
gi 74626004  174 -PHPQNLKNAQLVDELSAKLTQLHNEEAAWRAVAaNSVS---------SDKSILSFKKAVes-idSKQDLDKQDSPLPpd 242
gi 28201793  196 nGKASDFSLEASVAEMKEYITKFSLERQTWDQLLlHYQQ------------EA-KEILSRgs-teAKITEVKVEPMTYlg 261
gi 28201791  195 kEKAADFSLEASVAEVKEYITKFSLERQAWDRLLlQYQN------------EVPPEEMPRgs-teTRITEVKVDPAAYlr 261
gi 85102960  367 qPNPRNLEHDAKIAELEAKIKRLKEEKKAWQALAkPLPDleplypdsdPAKAPLPEPSLLda-eeAKILASLIEPDTAfs 445
gi 765669264 432 lPNSKNVENTKNLSILTSKVNAIKNEVKEWAVTL-DTSR---------PDLEWQELTSFSsq--pLEPLSDTEEPDLA-- 497
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74634016  469 l---------------lsdVALSASTFSRQIDQVEDAVNKINSCNVRASKFCDEQFQ-ALDNVLESRSRKRPRQSQDFRT 532
gi 74602447  464 stvlnnslaekindnynnvNENIPHDVETSTDKLYDASYRLSQARELIAKLQTDKLNdKVSSLVQNYMTKHLREPLSPGT 543
gi 74606276  424 -------------------KESIHSDFQKRVDGLQETTRLLKSSSILLNETAGMKLQ-RLNGCIVKKRPEDKNS------ 477
gi 74608578  393 -------------------NANPVKELEDRLKAMSMNAHLLDSTSKTLLELSRIKLD-KLRRAYYDTAKNEKKQIE---- 448
gi 74626004  243 dap------------elpnISKLKPKFHTLLDMLAENIHTLHSLTNAGPEVRSSYG-----RLAAQDFIAHRKSLLSFSK 305
gi 28201793  262 ssqnevlntkpdyqkilqnQSKVFDCMELVMDELQGSVKQLQA----FMDESTQCFQ-KVSVQLGKRSMQQLDPSPARK- 335
gi 28201791  262 ssqkevlstkpdyqrivqdQNQVFAYVELVMDELQGSVKQLQA----LMDESTQYLQ-KVSVQLKKRSMDQLDSSPARK- 335
gi 85102960  446 sfrr----------rtrsrLQNVQSSLEFKIDHLADSVHKLDMRVSTAGREADQVL-----MLSAARLKEREE----REK 506
gi 765669264 498 -------------------IADVETKLETKVDELRYQSHILNSHSLALNEITNSKVN-KLNIETMRKISSETDDDHSQVI 557
                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 74634016  533 IfnadrfrestldgeqTRDVLRTLS---------RLK 560
gi 74602447  544 Sswpvp-----nrritTKELLRGITrldd-pgvsQTD 574
gi 74606276  478 ----------------TKKLLRGLSr-------sLMQ 491
gi 74608578  449 ----------------STRLLRGLAs--------SLN 461
gi 74626004  306 Yv-------------dTMNLLRLLSeasyksssnESV 329
gi 28201793  336 ----------------LLKLQLQNPpaihgsgsgSCQ 356
gi 28201791  336 ----------------LLKLPLQSSp--------STQ 348
gi 85102960  507 Grvgt-------rdlpTIEVLRSLGril----paEGG 532
gi 765669264 558 N---------------PQQLLKGLSl-------sFSK 572
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