Conserved Protein Domain Family
Spindle_Spc25

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pfam08234: Spindle_Spc25 
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Chromosome segregation protein Spc25
This is a family of chromosome segregation proteins. It contains Spc25, which is a conserved eukaryotic kinetochore protein involved in cell division. In fungi the Spc25 protein is a subunit of the Nuf2-Ndc80 complex, and in vertebrates it forms part of the Ndc80 complex.
Statistics
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PSSM-Id: 311930
View PSSM: pfam08234
Aligned: 147 rows
Threshold Bit Score: 38.6862
Threshold Setting Gi: 74608166
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3VZ9_B         28 IHNEQLQFIFRHiDHKDPD-KPYMFTLSI-NEQgD--YEVTSCTPPLDC--ISEFQLKV-R----ET---NNFSAFIANI 93
gi 74776671   152 KVNGNNRFTFTCiDENFPE-REFFFDLFY-NEK-AqlYEGICCNPQ--VsdFEPNIELL-Ns---KS---ITFRQFICKM 219
gi 855317639  159 IDLEGIRITFRCiDRNHPK-RRFYVVLKInDEE-K--WELLRTKPCLENe--SALMKRL-N----ES---NDVNSFLRNV 224
gi 675884050   65 ntEQIIEIRFTNiNKNDPQ-KEFVLALNV-GYS----FTVKRCCPKIEk--IDKLLLTL-N----LT---ADWHSFVVSV 128
gi 209875411  152 kvNGNNRFTFIYiDANNPL-REFYFDLYY-NEK-TssYNGVHCEPYIh--eFQDLTNKLnN----RS---ICLRKFISNM 219
gi 914547492   66 LEDDKIVIEFSNiQDSEPQ-KKYRATLVL-KNG-I--YEVIETNPRINk--FEDFVDSL-N----KG---LPFTTFCCLL 130
gi 1005958221 135 eEPSKFKIGFSHiDPDDAE-KIFSVTIDI-KLG-T--IKVLEVDT--AEeeFKELEKWF-N----EKfavINLPIFVNRA 202
gi 156096408  144 LQDDKIAIEFSNiQPGDPQ-KKYRATVAL-HNG-T--YEAIETAPRLNk--FDDYVNGL-N----KG---LPFTTFCCLL 208
gi 294944789  136 IGPSVVRVRLDNvEGCDD---SLVFVLAR-DEK-TqkYFVSSCMPR--VtlLDKLVANL-NcrmpPC---TSLGGFLVTV 204
gi 357605556  134 nDNQVIFVQFFTeSKKDNEnYSVRLIRNI-KNG-K--YELLSVNPK--LkcLKELQKEM-C----DT---NNVPGVLCAL 199

                  ....
3VZ9_B         94 RKAF 97
gi 74776671   220 RKSF 223
gi 855317639  225 RKSF 228
gi 675884050  129 RKHF 132
gi 209875411  220 RQAF 223
gi 914547492  131 RRSF 134
gi 1005958221 203 RKIF 206
gi 156096408  209 RKSF 212
gi 294944789  205 REKY 208
gi 357605556  200 RQAF 203
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