2C5Z,2A7O


Conserved Protein Domain Family
SRI

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pfam08236: SRI 
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SRI (Set2 Rpb1 interacting) domain
The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilizes the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
Statistics
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PSSM-Id: 311932
View PSSM: pfam08236
Aligned: 110 rows
Threshold Bit Score: 62.1124
Threshold Setting Gi: 74626626
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2C5Z_A        12 RLEHNWNKFFASFVPNLIKKNP--Q--SkqFDHENIKQCAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYM 87
gi 366998103 616 vlEHKWNKYFATFVPNILKKYK--D--QhnLSHDHIKNCARDIVKTLTAKELKKNADKTPPEKPSSEKLAKVKSFVKGYM 691
gi 410080658 601 ryEHHWNKFFASFVPNLVRKYE--S--DvhLTHDHMKECSRDIVKILTSKELKKDPKNMPPEKLNKDKHAKVKSFVKSYM 676
gi 156847005 602 HIEHKWNKFFASVVPNLLKKYE--N--EhnISHEHTKHCSREIVKILTSKELKKDPSRAPDEEPTKEKRAKIRDFTTIYM 677
gi 367016577 598 HVEHKWNKFFASLVPNLLRKYE--H--DkqISHDSAKQCARDIVKILTSKELKKDVTRSPPDEPTKEKRAKVKQFTQSYM 673
gi 254586457 592 hlEHKWDKFFASFVPGLLRRYEqnE--G--LSHDHAKQCARDIVKILTSKELKKDVTKPPPEEPSKDKRAKVKQFTASYM 667
gi 365982940 688 snEHKWDNFFASFVPNLVRKNT--GdvE--LSRDHIKECSRDIVKTLTSKELKRDDPKPPPEEATKEKKYKVNKFVKIYM 763
gi 366997071 635 vSEHKWNKFFASFVPNLVRKNV--VgvK--LSHDHIKECSRDIVKILTSKELKKDDAKSPPEDLTREKKKKTNSFVKVYM 710
gi 403214852 611 HIERKWNNFFALFVPNLVRKYT--T--DvaLNHDYIKQCSRDITKILTNKELRKDPKTLPPSEPDRDKRAKVKKFVNLYM 686
gi 444323962 658 KLIRTWNKFFAMIVPNMLKKYE--K--EnhLKHSTAKNLSRDIVKILTKKEVQHNNNRSPPAEITKDKKLKVYKFVNGYM 733

                 ....*....
2C5Z_A        88 DKIILKKKQ 96
gi 366998103 692 EKFIIKYNE 700
gi 410080658 677 DKFIAKYKQ 685
gi 156847005 678 DKFIQKYQd 686
gi 367016577 674 EKILQKKKs 682
gi 254586457 668 DKFLIKYKK 676
gi 365982940 764 EKFITKYKE 772
gi 366997071 711 EKFIEkyks 719
gi 403214852 687 EKLVnkykq 695
gi 444323962 734 SKWFLKERR 742
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