Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 336973
View PSSM: pfam08246
Aligned: 60 rows
Threshold Bit Score: 39.9567
Threshold Setting Gi: 74876166
Created: 21-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74919279   55 RLYKRKYNKRD----EEINLEHRRFMTYLKNVKEIEKHNeryERNEETYELAINHLADMLPEEF 114
gi 74948152   37 EKFKNNNNRKY----LRTYDEMRSYKAFEENFKVIEEHNqnyKEGQTSFRLKPNIFADMSTDGY 96
gi 122114424  39 DDFLRQTGKVY-----SDEERVYRESIFAAKMSLITLSNknaDNGVSGFRLGVNTLADMTRKEI 97
gi 122118542  32 DTFLGAYQKKY----KAKYRMDRRKRAFKKNMQEIEEHNanyEQGKSTFQMGVNELADMDKSSY 91
gi 122021302  56 DRFLQEYGKKY-----DAREYVRRRALFEQTLARVRTHN---EAGNHLYVMGINHMSDWTPEEL 111
gi 74948282   31 DQYKAKYNKQY-----RNRDKYHR-ALYEQRVLAVESHNqlyLQGKVAFKMGLNKFSD-TDQRI 87
gi 471235525  33 DQYISDYSKNYa---KGTREYDQRKIIFESKLQEILSHN---QNTSHTYKRGINAFTDMSHQEF 90
gi 671409684  90 KDYVTALGKHY-----DQKETNFRMAIFESNELMTEKINkkyEQGLVSYTTALNDLADLTDEEF 148
gi 301104775  41 VDYALDYEKSYrndaNDHDVVQLRFRSFATNLERIQTHNeayERGEHSFTLGLNDLADLADAEY 104
gi 156384930 246 DKYVKKHKKNY----KDNKEHHTRREHFKHNLRFIHSKN----RRHAGYYLAMNHLGDRSDKEL 301
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