Conserved Protein Domain Family
Inhibitor_I29

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pfam08246: Inhibitor_I29 
Cathepsin propeptide inhibitor domain (I29)
This domain is found at the N-terminus of some C1 peptidases such as Cathepsin L where it acts as a propeptide. There are also a number of proteins that are composed solely of multiple copies of this domain such as the peptidase inhibitor salarin. This family is classified as I29 by MEROPS.
Statistics
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PSSM-Id: 311939
View PSSM: pfam08246
Aligned: 60 rows
Threshold Bit Score: 43.0267
Threshold Setting Gi: 74876166
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75311183   49 FSRWMAQYGKAYs-WPIEHEKRYQIWKDNSNFIGSFRseteissgvgAFAPQTVtdsFV-GMNRFGDLTPGEF 119
gi 74920313   29 FTAWMTSNQRTY--ASSEFTNRYNTFKSNLDFINQWN----------SKGSKT----VL-ALNEFADISNEEY 84
gi 74921351  216 FDKFRHHHRRQYa-SSMEHEMRFNIFRNNLFKIEQLN----------KFERGTA---KY-GVTKFADMTVAEY 273
gi 75034681   42 yGRFKERHGKSFg-EDADEGHRFNAFKQNMQTAYFLNt---------HNPHAHY---DV-S-GKFADLTPQEF 99
gi 160431607  26 YANWKMKYNRRYt-SQRDEMYRFKVFSDNLNYIRAFQd---------STESATY---TL-ELNQFADMSQQEF 84
gi 121977078  42 FQKFKKTFRKRY--ADSEGDYRFQIFAENYNYIHNYNqi-------nENSQDNI---QL-EVNEFADLSLQEF 101
gi 74919279   54 yRLYKRKYNKRDe-EINLEHRRFMTYLKNVKEIEKHNer-------yERNEETY---EL-AINHLADMLPEEF 114
gi 121986672  36 HDDYVLSLARLYrpHLNVEHLEFQHFKESVRRVREHN----------KKVNATY---TLsIDSPFAFMSDEQF 95
gi 255636047  40 YERWRSHHTVSr--SLGDKHKRFNVFKANVMHVHNTN-----------KMDKPY---KL-KLNKFADMTNHEF 95
gi 474142692  41 YAEWMSEHRRTYn-AIGEEERRFEVFRDNLRYIDQHNaa-------aDAGLHSF---RL-GLNRFADLTNEEY 101
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