Conserved Protein Domain Family
dCache_2

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pfam08269: dCache_2 
Cache domain
Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 (sCache_2) duplication.
Statistics
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PSSM-Id: 311945
View PSSM: pfam08269
Aligned: 43 rows
Threshold Bit Score: 82.3995
Threshold Setting Gi: 81653341
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123549839  33 TEEIFNNSTKNLKQELILKEKNNTISKVKMAVEILK----YENSTLEERLKYKISDRVNKAF------------IIGSNI 96
gi 123739908  40 THRDVGRAMLHAEESSAQNVLKLVELNIKAGYDQLT----GDKIEILSNLQSDLQSVSEIAQ------------SSFKVY 103
gi 81653341   66 LAPKMKEEQFKTETHTIERLLSKMEHQVRLAIKVNQfhssSQKTNNDLRLQNHLQNLHLHALshpsasleqwiaTLDQEF 145
gi 502776616  38 TNTEFETERAQLVKNFIETKKTNLKSEVGRLLDFTK----FNTVQTRNAIKENMKDRVNEAV------------SLAISY 101
gi 503279210  37 MHETVMTNIER----QLDASTEALRAMVQSA--------------TDASVRNRLRAIAEKNR------------DILVGL 86
gi 505935463  38 ifafilhftftqlNATIEEGMEAAGSSIVDMIEL----------TVNSSIQSYLRAIAEKNL------------EIIKNY 95
gi 502899113  40 EYSNFRTHIKSFKNTLIEREMFYVKTSVQNLKNDID----FESLSIINSKKQRIKNQSIIAY------------NLAYSL 103
gi 505940724  26 ggyLIASALTHREEARAQADMTVVRQLAETATQTVF--------------THTLRTTAENIR------------LVCQTL 79
gi 503018974  40 LSADYLQT-------QMKSSTRTLHNLIGSL--------------LRNSVRSYLRSKVEVGV------------DIVKEA 86
gi 506332755  28 TSSTLEEDMAHFQGRTARNTIRVGMLYLQEGHQALD----RYRKHAFQDRKQAVKDAMTLFL------------AQVGSF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123549839  97 YAQ------NR-E-FKSEKE--------IKKMIVDVLRTMIw-NNGESFIFILDKKGTFILAPQYl---kHKENKSVIDF 156
gi 123739908 104 GDL------YK-SgRVSQEE--------AEAMAFKWLREVR---FGEVEVFVFNRQGGVMAHPEH-----SVEATYITSL 160
gi 81653341  146 QGEacrallIK-EnQILHSTk-------PLPSASPLLSSLTalPQGEWHSY---------LHPRP-------QGa----- 196
gi 502776616 102 NKK------FH-N-KFTDKE--------IDRNLIDFFKLYSw-DEGKGYLYILDKKGNVIYHPKYk----S--GTNLLKL 158
gi 503279210  87 EAE------VQ-AgRMTGQA--------ARTLARTILLSQS--IGQTGYVYCITSKGVVAVHP-Ne----QLLG------ 138
gi 505935463  96 HQK------QLtG-ELSENM--------AKMAVTAILRSQq--IGRSGYISILNSQGVFQFHPNS-----DLEGKPILKM 153
gi 502899113 104 YKS------SK-N--LSKEE--------QIDLIEKSLKEIAq-EKNDINYFILNTKGTLLLNTDYp----KNEGINFLDF 161
gi 505940724  80 FHQ------HQ-SgRLTLDE--------AQRLALEALAAQR--VGQQGTVLCIDSQGMLLRHPDTtrirtRLDAAVFSRL 142
gi 503018974  87 LRE------QG-LaDLPEEEwpvslppeLEERLVNSLLSFH--VGESGYYYGIRSDGTVFFHPDP-----KIAG------ 146
gi 506332755  92 YEL------YK-AgELTEKE--------AKEAAFKLARNTR--YFNNDYFFIYTDKLKALAHPDR-----SLEGRDLSKG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123549839 157 QDSS-GRYVIKEEINLV-NSSGEGYLWDTFTR-PnkdQNMQYKQMTFVKDFEIYDWYLGSSEYLDIVEEEIQ-------Q 226
gi 123739908 161 RDFK-GRVIYQTMADDNlDASGD-KAIFNWRK-Pg--SDRDSRHIGYFLPLPDWKMTLVAMVDFEYVEAESRkkmsaiiD 235
gi 81653341  197 -------------------------------------CPTSDKETLLFKPLGTTGYRVGVHCQSQDFISERRafeseigV 239
gi 502776616 159 KTPF-GTMPVQTEIVTA-FEKGGGFVENMMPKeAd--STEFVQRISYVKPAGIHDWYIGSSFNEDFISDVIK-------E 227
gi 503279210 139 QDLS-GQWIGREQAKRL-T----GYMEYEWAN-Pg--EMRTRPKALYMVYFEPWDWIISASAYRQEFTSLINv------E 203
gi 505935463 154 ETYSpAWSFITEQI-----TKKTGYMEYVWKN-Pd--EKTFRPKALYMVHFKPWDWIISVCCYREEFQSIID-------F 218
gi 502899113 162 EDLD-GVKFINKMIN-A-NPNTQNFLDYNWYR-Pn-------KRITYSRHLKELGLIIGSASNLESNHVELT-------D 223
gi 505940724 143 QQLTa-----------------dGYLEHq--------PGGQPPTALYRAAFPPWGWTILATCELGERQRMLP-------Q 190
gi 503018974 147 SNQR-EREPVKEQLLLRn-----GYLEYRWRN-Sd--EEEPKNKALYMAYIPELDWILSATSYREEFVHIIDl------A 211
gi 506332755 150 VDKN-GYAYGPDMIRKAtREGG-GFVNLLWTR-Lg--ENDPISKLLYVKGFPKWGWIIGTGAYVDDIEGAVEnqkqdliR 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123549839 227 SSVTI-LRNINKN-ENDYFFIYDMNG-------KIILHSq-NPELEGKNFL-DEKDKTSIDv------------------ 277
gi 123739908 236 SLRKT-FPDIKVA-NTGYAYLFNGQS-------EILVPPpgndeegeap-----------------------mslngeqq 283
gi 81653341  240 ILKES-FQSIKEG-NPGFAYMMWVDGsertcdhNATLRTslESEASLYNRVcCVSETSPTDqpltgdlkaadylrasttq 317
gi 502776616 228 KVTHR-IDTVNFD-NDGHYFIINTDG-------RGVSIPg-NKDLNGKDLT-EISDSSGVFy------------------ 278
gi 503279210 204 DFRAG-VASFRVG-DSGYAFILDGEG-------NMVFHPw-LKG----NMT-DAIDAAGTEl------------------ 250
gi 505935463 219 KVIEQrIAAFKYG-RSGYAIILNQQG-------EFLVHPh-LSDAD---------KPRFAEq------------------ 262
gi 502899113 224 KLLKK-ITLQGFN-NDEFIFIYKINSl------TDIMHKs-KLLIQKNIIT-SNKE---LEa------------------ 272
gi 505940724 191 ILAAG-TPATALPvDGRQSFLLSPSG--------VFWPPlfpeaa--------------------------------ptp 229
gi 503018974 212 ALRRT-INSVLIG-KGGYSYVIDRAG-------TFIAHPylygkdar----------------------------gympa 254
gi 506332755 225 DMRKG-FSQIRLA-ETGRLFIFDNNK-------NVLVPPlgagpdfa----------------------------ktlnl 267
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 123549839 278 --AKKLLQSIKIEGS---NFASYNWKNPKSG-----LIEEKISYFEKI--PNTNLMIGSGFYTKEIN 332
gi 123739908 284 nlLAELIGQIAAQEQi--GQVMYHYLDPFVAsarhdEERQVVAYVSYF--KPFDWYLSVVVPVEEIS 346
gi 81653341  318 epLRHWLDKEDDRGN---------------------LIHPAITWARKFetPAYPLILAVTLYEEEIY 363
gi 502776616 279 --YKNLLSYALQKND---LFVFHKEKYKDWD-----KTNQVISYCRIY--EQWNWLMCGTVAMNDLt 333
gi 503279210 251 --FQHIRRI----RD---GKIAYSWLDPGRD-----TPRDKLMHFRSL--PELGWIVASSSYLDEVY 301
gi 505935463 263 --IQKIIARAGTGNT---RMVKYLWKNPGEQ-----DEREKILFFRRI--PQFGLIIGVTTYTAEAY 317
gi 502899113 273 --IKELLIKTNYKAN---EATYYDYN-------------QKLFYATYI--KEYRYFIAVGVNLSNIN 319
gi 505940724 230 eqRQALLSLAETMRRqqnGRIT--WTPPTAL-----QGEEKTILFRHQ--PDNDLLAGVVVPSAALR 287
gi 503018974 255 deFSSILQRFYAEGE---GIASYYWRTPSGN-----KRRLKIVNFKYI--PDFDWIVATAFYWDEIG 311
gi 506332755 268 ntGNSLMHDLKEVGKlgdWRLDYKVRRQDG------EIVERQSYVRYF--APLGWYVASTVPKQEIF 326
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