Conserved Protein Domain Family
TIM21

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pfam08294: TIM21 
TIM21
TIM21 interacts with the outer mitochondrial TOM complex and promotes the insertion of proteins into the inner mitochondrial membrane.
Statistics
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PSSM-Id: 311963
View PSSM: pfam08294
Aligned: 13 rows
Threshold Bit Score: 176.713
Threshold Setting Gi: 50401347
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1723658    67 QVKSASTFTFSGILVIGAVGISAIVIYLILSELFSPSGDTQLFNRAVSMVEKNKDIRSLLqcddgitgKERLKAYGELIT 146
gi 74609048   43 KLKALTSFTASSLLVVGGVGVSGVVLYLILSELFSPSGDTMLFNRAVTLVEDNEEVRKLLqcndssfkKERLKAYGELVT 122
gi 83305918  100 RIGRAFTFSLSSVIVLGATCISVLVVYLILSELFLPSGDTRTFNKAVRMLESNELAHEALgf----kkGQRVKAHGEQHA 175
gi 74634972   99 KIGVFFQLSWYLGIILAALGLFGLVWYYLIMELVMPSGDVRIFNRAFKEIEKNEDVMRVL--------GGQLSSMGEGGG 170
gi 50401347   62 KAYRTSANIGNFSIVIFGGGVFGLIIYALVTSIW--KGEAHYGDEAFELLKANEECRYVF--------GDHMKALGEATH 131
gi 74616711   82 KAGRAVQQTFNFGLVILGVVLTGGIAYLLFTDVFSPESKTAYFNRAVDRIRADPRCVALLsp----gdPKKIAAHGEETH 157
gi 73918915   99 KVKEAGRDVTYLIVVLFGVSITGSLLYTIFKELFSSSSPNIIYGKALGKCRTHPEVISVF--------GEPVKGYGEMSR 170
gi 74869970   68 KIKENTKTASYTAIIIAGLGVTCVMFFAIFRELFSSESPNNIYADALRRVVEDPRVQDAI--------GAPIKGFGETSR 139
gi 74799747   66 RVKENTKTASYMGVILLGVGVTGMLFYVIFWELFSSDSPNNIYSEALERVKEEPRVKDAL--------GAPIKGYGEETR 137
gi 74695199   63 KVRAAATFSASGMLVLGAAGVAGIVLYLILSELFSPSGDTQIFNRAVSTVEGDAVARSLLqcedgvhrSERLKAYGDSVG 142
gi 74607440   63 RIRAFTTFTFSGILVIGATGLAGVVIYLIGAELFSPSGDTQIFNRAVSKVENDEVARRLLkcndtetsTERLKAYGEILT 142
gi 62858217   87 KVKEAGRDFTYFIVVLIGIGVTGGLFYVVFEELFSSSSPSKIYGEALEKCRSHPEVIGAF--------GEPIKGYGETTR 158
gi 268564270  79 KVAEKASNTFMYTAVVAGVGLIGAFIYVLAGEFFAQDSPQTIFNKALALVREDGRCQDIF--------GASIAGFGEETS 150
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1723658   147 NDKWTRNRPIVSTKKLDKEGRTHHYMRFHVES--KKKIALVHLEAKESKQN--YQPDFINMY--VDVPGEKRYYLIKPK 219
gi 74609048  123 NDRWTRNRPIVSTQKIDKYGKCHHFMRFHLES--KKKLGLVHVEAVDSEQN--YKPNFVSMY--IDIPGEKRFYIIRPK 195
gi 83305918  176 -DKWARNRPAQSVRTRGADGKDYLFMKFQVESp-SGKYGTVTLEQVDRTF---WSSEFLYIA--LDMPGNKRIYIKEPK 247
gi 74634972  171 -GRWGRNQPPVSKRGIDKYGREHIWMNFYVSG--DINEGRAKLELVQNTDSklSSERFVYRYfvVDIPGHKRIYIAGNA 246
gi 50401347  132 PLR--RTHGILTSRVWDHHGVEHLVLQFHLIG--NERKGHVFGRLVNVQ----GDYKWEYLF--VDVANYGKIIIFDHT 200
gi 74616711  158 -NKWRRARPIAATVEKDNRGVEHLKMHFHVEG--PRGSGVVGLHLTKQPGH--WEHEYQTFY--VDVRGHQRIYLENKE 229
gi 73918915  171 RGR----RQHVSFTEYANNGLKRIRVKFYIEGsePGKQGTVHAEVEENPRS--GQFDFRYIFv--DVAPKRSIVVEDNR 241
gi 74869970  140 RGR----RQHVAHSSYERNGKPHMRMQFYVQG--LRNKATVQLESRRSDS---GKLEYRYLFvqLDHYPRTTIILEDNR 209
gi 74799747  138 RGR----RTRVAHTQYVKDGVEHIRMQFHVQG--FRNRGTVHLEKRKTDA---GGYEYRYLFvqLDYNPHSPIILEDNR 207
gi 74695199  143 DDRWTRNRPISSTRRLDASGREHYYMRFHVET--GRRRGVVSLEAQQSDDS--YQPEFVRMY--LDVPGEKRHYLIRPE 215
gi 74607440  143 DDRWTRNRPISSTRRIDKEGKEHYLMRFHVES--KQKMGIVHVEAKESDVN--YQPDFVSMY--LDIPGEKRHYLIKPK 215
gi 62858217  159 RGR----RQHVSHMEYVKDGIKCMRLKFYIEGlePRKQGTVHTEVKENPES--GKYEFQYIFveIDTYPRRTIVIEDNR 231
gi 268564270 151 RGR----RRHVAHHKYEKDGMQRIRVLFHVKG--DRDEGIAQAEMEQRD----GDWEWRFLYveNKRRPKTTHVLIDNR 219
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