Conserved Protein Domain Family
cwf21

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pfam08312: cwf21 
cwf21 domain
The cwf21 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe. The function of the cwf21 domain is to bind directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevent Prp8 from binding. The structure of this domain has recently been solved which shows this domain to be composed of two alpha helices.
Statistics
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PSSM-Id: 336993
View PSSM: pfam08312
Aligned: 152 rows
Threshold Bit Score: 28.4873
Threshold Setting Gi: 74632324
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 74803008   755 REIEVKIVQYQDEFESgtrQ-VrTGWTLHEEIDSYRMKLLKE 795
gi 226499190   69 RQVELKLLVLRDALEE---HgY-TEDEIEERVAEARKAAEev 106
gi 1142838373  15 RQVELRLLVLREALEE---QgY-MEAEIEARVDEARKateae 52
gi 586676215   61 RQIQLKLVLLEETLAD---QgY-TEDEILDKLHEAKKRFEAE 98
gi 697130158   65 RQIQLKLLVLEDKLTD---QgY-TDAEIAEKLDEARRNLEAt 102
gi 727473858   42 RQIHLKLAILEDKLVD---QgY-SDAEIAQKLEEARVNLEva 79
gi 1072980580  65 RQIHLKLAVLEDELSD---QgF-SDAEIAERLEEARLKFEaa 102
gi 168025284   61 RRIELKLMELEDQLVD---QgY-PDEEVLERVEALRKRLEAa 98
gi 1079240806  64 RQIELKLVVLEDKLID---QgF-TDAEIAEKLDEARKTLEAa 101
gi 255074245   64 REIEVKLAQLEDDLEE---KgV-DAEEIAERLKEARVKFERE 101
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