Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 
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Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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PSSM-Id: 311975
View PSSM: pfam08314
Aligned: 71 rows
Threshold Bit Score: 341.579
Threshold Setting Gi: 444322043
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D          7 YLLACIFASRADTRNIKK-LSTRLGSQSK-------------YLEILCVLW-PELDDP----KNLLFLrel--------e 59
gi 74589261    15 VYTIQLLTSNNNVHNINAyFRLLSAKVLSsnfdclkittranILKTLLIYSyPLNIPLqdiiKLAKLI------------ 82
gi 169844647  182 VTSAQNLATQQFFDAIQLmFKKHRSELWPsr-------------fAILDAI-PEHAVPssyrHLLPGL------------ 235
gi 156842208    6 YLLCTIFAARADITNSSL-LYDQANGNFTq-----------eCFDALCILW-PELMDPnglsFVFQQG------------ 60
gi 366999090    7 YLLATIFASTADVEKLTI-LKNSFTNSSE-------------LLDIICVLW-PELDDPillrNFLTNLeln--------d 63
gi 365991194    7 YLLACVFASKADSTNLSQ-ILRHVHYSLD-------------FIKAACILW-PELDDPmnliSLFPTI------------ 59
gi 255727665  106 VYTIQLVSSSTDIDKLQAfLRLLNAKVLSsdtneftfttknnLLNAILVHTyPLNLELeeltKLANLL------------ 173
gi 254579142    7 VILAAIFAARADSTNCET-LWTFFH---Ssd----------eLFDIICSLW-PELDDPt----kLQFLfd---------- 57
gi 667787932   11 LYIAVQYASAPSLQTLSE-LILKFPYIFSkr----------vILSI-LNFV-PECIDPdeylSLIFDEky---------- 67
gi 444322043    7 YLLTCIFASRGDSLNLKIiLKNEKVNGVNfv----------eKLNIVCVLW-PELDDP----SNLKFLftddeemtddsd 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D         60 eeVQ-SPEGE------ETtdedv----------ivelLe--sDSSLIPL---IESDTTTRSNRYHEL------QEfiskk 111
gi 74589261    83 --IY-STQSE------IEst---------------deDg--fDLEEFSLslkSDIANTVSLKATANE------LLvdtni 130
gi 169844647  236 --DN-ATNLElvwpqePWr------------------Pe--pDV----------SEQSEIRSVLREI------EVgfn-- 274
gi 156842208   61 --PS-DDQVQ------LSdpndl----------mmnlLe--vDNKLIPI---IELEHDIVHERSEKV------KDfv--- 107
gi 366999090   64 lnAD-ENPID------EDnil-------------vslLe--tGEDLVPI---IEMDVETVSERVSTV------KE----- 107
gi 365991194   60 --EL-GNDDN------DNnasanddgslsdenlvvklLe--nNPDLIPL---VEVGNTIVNTRYLSTkyfiesKL----- 120
gi 255727665  174 --ID-PSNIT------KTd------------------EtdsfDVEEFAFglpTQIENESSLLATAQD------LMvdt-- 218
gi 254579142   58 psEK-SSSGH------STnpqdl----------lvelLe--tDEQLISM---VEMDSDTITQRRQAI------SR----- 104
gi 667787932   68 ------------------------------------eGe--dDMDSSQIsktQNINNAALSQKLKKL------HI----- 98
gi 444322043   72 liRSyDGDDI------YRnpadl----------vvniLk--nNEELISI---IESDHNCLNERYDHM------VDyintk 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        112 lnnktL------------------ENFEEWLRERILICNexiP---ETPLLYSVLWETAksk------vlST-KFIGW-- 161
gi 74589261   131 kcqslGildfsaaa--dnddddddELFLSFICAKSFYLSqfyQ---DINDILPLFENVS-----------FP-KFNAW-- 191
gi 169844647  275 --elvLtndlpvi-----tepleaEALRKWYSNQVDVII---Q---ATGIVDAALAIVQhgasqg----------ipgld 331
gi 156842208  108 ---skRilqleqd-----slitfdNILSNWLRRRILVCDefnP---NNVLFNEPLWEThs---------kDDiKFAQW-- 165
gi 366999090  108 -----Yinrrlvevt-ldeitsfdDTVSSWLRKRILLCDelnP---FNVLFNKKLW--Keik------piDP-EFMGW-- 167
gi 365991194  121 -----NglyssniipletslssleDLQSLWLQIRILVCNeviP---EMTSFYEPLWTHSnf-------hiNK-EGKDW-- 182
gi 255727665  219 --nvqSsyigglk-----fgstpdDLLLSFIQAKTIQLSkyfD---NVNDIMPLYERVS-----------SD-AFQSW-- 274
gi 254579142  105 -----Yaaeymkqvt-pydrikfvTPMGDRLRKRLITSN---ElsdQLPMQYHPVWKVVsi--------kdE-ELPKW-- 164
gi 667787932   99 -----Yqdetkt------nncisdEELYAWFISRALQIE---E---ETGLISFSRKLVLtsk-----ypiPP-KVQEWgr 155
gi 444322043  125 lsviqtl------kgsldvlntelSLKYTWLKNRIILVNnfyP---MDTIFNRTLWSLKvfrdkpindqsHS-IFFNW-- 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        162 -VEGVLKPLDHLNKRLHLI------FKINEWEKXPDSELFKIIFDGVeDXqGY--I--GIADVIEDELAPTLSYG----- 225
gi 74589261   192 -FKGIILP-----YKYYYSh----------FGLAYSINTLNSYLAPE--------S--SYSSRLHLLLGPLKTEKilnne 245
gi 169844647  332 eLGEELSLLSRLVYDTPQAqftnddWTVSRWRSMSPESVVRAYLAHSpPE-S-------LPQDISSLVMPYLYVLearae 403
gi 156842208  166 -ISGIIKPLSYLNLR---Sgs--ktLKIKDFENFKPVDIINLILGNInDD-EYnlS--IDASIIIQELIPYLKYSka--- 233
gi 366999090  168 -VNGILEPLDFINNS--SDir--vqFRIIDFEALTPNNVIELLTKNLlEN-EY--SfnNKNVQQIDCLISYLNYTnsftl 239
gi 365991194  183 -IECIIEPLNYINSRLGSK------LKIKDFSKMDPIAVFPLILE---------------GGDMKKELIPYLQYT----- 235
gi 255727665  275 -FAGVISP-----YKYYYDh----------YGQVYNGATLQEYLSA------G--E--TLKNKFEMLITPLSAGKvsnie 328
gi 254579142  165 -IEGIVEPLDHLNKRLNSS------IKIKEFENMDPLSVFDMIL-NTpDE-NP--D--TV---LQRELMPYMANG----- 223
gi 667787932  156 gIVSTLESVINRQYNNPLLef--nvPTLREFETLNHKEVIDILLQHL----EN--E--EILEEIKSSIIPYISYCqkssk 225
gi 444322043  193 -INGTIYPLYYINQRLNKT------LKIQEFENLKTEDVINMILNSQ-----E--T--LKKETIVNELFPYIRYN----- 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        226 ------------------KKWETFI------------------TEFFNKQQFSlksdtnyqlfIK-----LYy------- 257
gi 74589261   246 swfknviipiddyygkdlHPLNEWLfdnengyc---skpvesvVRKYQFWHVClkcihhhydlKD-----YQ-------- 309
gi 169844647  404 rag-------spdpdlpnRLLYDYIlsip-----------lehAAAVFEASKP----------Tlpa----------sqr 445
gi 156842208  234 -----------------yDIFLDIVfnpsvf-------rfdtaVNYYNF--------------RQ-----LYs------- 263
gi 366999090  240 -------------fleqkFNTNSFLfkkkq--------nylvfDAIFTK------------------------------- 267
gi 365991194  236 ------------------KSFTSFL------------------NNFCTVTQFP----------MDnqenyELldn--lid 267
gi 255727665  329 qwianviipiimyhnndfRPLNEWLfysdmgatvtkgsnktspVTKYSVWSSCi-------------------------s 383
gi 254579142  224 ------------------DYYERFLhsfltt------kdfplnTN-YNFEVFY----------QL-----ILsl------ 257
gi 667787932  226 --------------tniwDSLWSWLlnfsfkq-------------------------knlnliKL-----IS-------- 253
gi 444322043  252 ------------------NCFDLYL------------------ESFFNSDKIQinnlsdyqrfKS-----LFieineeir 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        258 SleKGVKDNSEASRKLQSNVVDILF------HN---Senl-fnLSSLTHKLDELWSILsgfp------------------ 309
gi 74589261   310 --------------IILNSFLSACYfygfkeDT---DsvstieLVEIYDLIIDTITLFdihteelrlpdidy-------- 364
gi 169844647  446 V--LRDDED------VARLALACLYgs---eSL---Se---------WPTMSRIFECMpawdtvdegetdeeaadttira 502
gi 156842208  264 L--LSNEIPIEFKEKLEELSLKIIY------DN---S-----------------ANMLnvtssseleqlltqfs------ 309
gi 366999090  268 ---FNESNVMADKENFQKAALSIIF------EN---Skel-mnIISM----DELKQLLdafdqniet------------- 317
gi 365991194  268 I--LPSVLPQDEIHTFKTSLLRIIF------EN---Sg-----------------nLLkfttlatlsnl----------- 308
gi 255727665  384 S--LNRHFELEEFKVIIETYLAACYyfsfkeDTdvvSsv---dIMKSYEVIHDTLSLLrgssktlapgsqdid------- 451
gi 254579142  258 --gLRGQETNKYLERFKRQ---CAYil---fKN---Gpny-lnIGTKYRLNQVLLTIGdetpvgdl-------------- 311
gi 667787932  254 ---FNNVISSEKYSEFSKYAIASCYcl---qST---Eee---nIHSMKIILQNLKQNLnietnsntsvlndi-------- 313
gi 444322043  291 SffGNLDELTSINSKFQTNSLDIIL------KN---NkwlitqFKGTK----EINELIirid------------------ 339
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        310 ----------------deitIEEqKTITALExKQ-FXEFFIKCSTKF----SF------KEIF-AI-TQEEESAQLAHFS 360
gi 74589261   365 ------kdipfdchnlkefqSAT-NPISPLFqIG-AIAYLRQVIETCqkllPInrl-tiKKYFqLK-YQNKEMDTKREIL 434
gi 169844647  503 lgnfvapstsrtscapkdllTFF-KPLSIQAlSR-ALDILDVHLESGeilsRWsvpaplR--WfLR-SHDDVNEQRAWAN 577
gi 156842208  310 -----------------pgtkvkstsltannlKW-FAHYMNLCFQGYs----------lSDINaIC--QSSEQEQLAHFA 359
gi 366999090  318 -----------------------anginskilLS-YIHLISIFLQDYs----------lKEVH-LI-SKENEASQLLHYT 361
gi 365991194  309 ---------vnvtadnsvmlTDY-DNLHYYD-LQkYLLFMQNFSKSkd---------sfKDLY-LI-NKGTESSQLAHFA 366
gi 255727665  452 -----ygnipmdcasfnefnTPS-NPLSALFhSE-CIPELKHAIETCqklfPInkl-tlKKYLqFN-YDPSSIDLEREIL 522
gi 254579142  312 -------------------------gitvetlLA-YSSLTDKLFHGYhmqdLY-----------AI-SKDDESVQESHFA 353
gi 667787932  314 -------kisslnvftpeniQDY-SELITPN-SD-SLSLLEIMIKTVliinSTkeickiTLSEaVCyRNKDKKSQISLLH 383
gi 444322043  340 ----------------hnieAK--KYGNCFKiKK-ILRIIENIFHNDit-yTI------DEINdTI-ENNNKEQQVSKFT 392
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        361 SLCH---E--EfNkA------NEISSFLQAXYETVL-----------DisKDDKIFTRI-SXDEKLYSILEILLQXNEFA 417
gi 74589261   435 KITN---N--I------------NASNWKQLLNSIAlfqk-----------nfiFNERI-SATVIERFLLANL-----FD 480
gi 169844647  578 RMAR---R--A-GgSvd---pLTTMEDWEWLLEDMLklt------esNesGLRGAFGLL-ARDEVLSIYFSGLLSTGKFD 641
gi 156842208  360 SMVK---GkiC-NsQs----qQTID-----VISNLIs---------eSkiKEKQIFTNL-TIDKQISIFVEILLELGEFD 416
gi 366999090  362 SMIK---Ak-I-MsKg----fKTSSS---TAVNEILsvi-----tgsAsnSEQIVFTHI-PPKRQISVLIDLLLELGEFD 423
gi 365991194  367 SICKeelS--A-NaNk----pSINNAKIKDIFDSIVh------------eDNDMVLSHL-TIERKISILLETVLDLGEFD 426
gi 255727665  523 RITS---N--I-Nh-----------SNWQQLMRSVDlfkssfvseenT-------NGQV-SSIIIERLLFANL-----FD 572
gi 254579142  354 SLSR---K--C-LeTvv--seETTMKELKELLKH-------------GksSNNVIFSRL-SEQKKLSIIIEILLEFGNFS 411
gi 667787932  384 KMIP---Q--N-PhFl----sKLNDSEWIKLRNNIKwlhd-----------vslIYKNI-PEIEYESFLLYNILRTTKFN 441
gi 444322043  393 EFLE---N--LmKnGysfrieKLITNSE-------------------NikDIKFVFNKFeTTEEIERLVIDILMNYREFD 448
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        418 YIEA-I----------IE--RFDYSNntqiyeLLVKFFWHFFNNASN-GLRKEPEXKKASQTLQIIQKHXs-----QR-- 476
gi 74589261   481 VVDE-Vyfek--klgdIT--VNELYD------VVLDKFWDCMNHANS-LNDKSGSLHNAELCLKLFDKLVlekdlaED-- 546
gi 169844647  642 IAKA-Mlrgsh-pkisLS--PEVVED------ICLKCSRELYDNASS-GNYKIGDMKLAYDCLD-----V------PP-- 697
gi 156842208  417 LLQNfVtln----nskLE------EN------VLEKYFWNFFNNATN-GLKSRPEIKKAEKTLQLMD---------VQ-- 468
gi 366999090  424 LLQD-Lmee---------qnSQLEEA------GLEKYFWHFFNNASN-GLKSRPEMKKAQKTVKLL---L------EQ-- 475
gi 365991194  427 VLEE-Vvt-------qYK--EKFITK------LLLKFFWIYFNNSTN-GSKKSLGMTKCRKVLNLLSLEA------HTkg 483
gi 255727665  573 VADE-Lffn----dslLPisTNQFYS------LVEEKFWASLNHAVN-LNEKSGLLYNAHQCLNLFDKLVlkkdleES-- 638
gi 254579142  412 FLHE-Lii-------tyQ--YKVNEE------VLVKYFWHFFNMASS-GQRHKRDLANAEKLVNLL---L------EE-- 463
gi 667787932  442 LAEN-IyikrnkgnmpLK--DVMVEK------ICIEIFLEFFDSSSN-GNITKGNMKNAYNLLQTIKQYY------NS-- 503
gi 444322043  449 LVGD-I----------LG--SHSDEDsqi-ndIVIKYYWKTIKKFNNdGTKKNVEMLNIEKILTILKH--------RK-- 504
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        477 -----AGTnLTKLEVLLEISDKLSHYSINLNKshnGArd--tAFKPSNILEYr--D-C-PLDIISNLLELNPRLYKDLPT 545
gi 74589261   547 -----NHRdIVKFKHLFKAINALKRFKLL-NR---NQ-----PYTPQQLIINfanG-N-ILKLINIVLEQNPKSYLAFDK 610
gi 169844647  698 -----LSDqIQLEKEFIEATSRICSFNVISRA---GV-----PISPIEIRLT---K-D-RLSLVSQVLSSNSDAYKHTEV 759
gi 156842208  469 -----NSTvYKHLHTLLKVADTLSRYSINLGK---GI-----PFKPCNIFEF---KyN-PSKLISILLELNRDLYKDVAN 531
gi 366999090  476 -----NEPkFKHLEILLHIADLLSYYSINLGK---GV-----IFKPSNIFDF---K-NhPSQIISKLLELNDGLYKDKNT 538
gi 365991194  484 rqdliTKEeLNSLQTLLDVSDDLSKYSMNLGK---GH-----IFKPSNILDF---EtK-ETGLISILLESNNSIYKDISV 551
gi 255727665  639 -----SRQqIVKFKHLFKAMHALKNFKIVIVS---SDadrnkPLTPYALINSfadN-N-VMNLITIVLEQNPKSYLAFEK 708
gi 254579142  464 -----NAPkYTHLRILLDVTKDICDYSINWGR---SL-----PFRPSHLLKF---KeD-PFGLISLLLESNRRLYKDVPA 526
gi 667787932  504 -----EQ--LESFSYLVKVTNTLYHYS---------H-----KFKPVQIRLH---N-N-PFEILEDFLSSNPGIYKSIDE 557
gi 444322043  505 -----EVNeYHYLRQLVNNCYELSKYSI----------------KPIDIIQYk--Q-E-PIKIISKMLENNNGLYKEFEI 559
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        546 TKSLLFGIYDSlsiN------------REg---qTGKVE--VDLXVLHIDYALVNLDFGTAYELGKQVFeicqeag---- 604
gi 74589261   611 LYRILNDMILFynddnhk----------dgkqhaDNYYF--NKLKTACIESALIDNNFNYAYKQSLELFdyldgk----- 673
gi 169844647  760 MLDLTYKLGFr----------------------dDVSAT--VKVLAMLAETALQMEDFTRAFECTQRMVaiihdlq---- 811
gi 156842208  532 SMNLIDQLVEAm--Q------------ISrehldRESEY--NKILVIHIDHALVNMDFTFAFQKSKELLrrd-------- 587
gi 366999090  539 TSLMLKELFEGm--N------------LDitgdfFVQEQ--IRVSEFHIDNALANLDFYFAYHESKELLtks-------- 594
gi 365991194  552 TFEIMKKLNVA---MacqcpfinhnqlKPaqkkdVIVAY--MRLLTLHIDYSLVNMDFNFAYKLTMELFdkfktyigqqs 626
gi 255727665  709 LYRILNDLLIF---F------------GEdgdgeNNFYF--KKLKTACIESALIDNNFNYAYTQSIELFkffedk----- 766
gi 254579142  527 TYSILQKLLVA---F------------EIakqgtTDSEEnlVKVLVLHIDHALVNMDFQFAYENTRDLLkk--------- 582
gi 667787932  558 VMEICNDLLLStnkN------------YLy----QKEIQ--AKILCIIAETALSQNEFDFAYDICINHLfslfeavd--- 616
gi 444322043  560 ---FNEKVYNNlqiE------------I------TNDER--IEIINLQIINSLKNFDFNFAYQMIQDLFanyq------- 609
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        605 -----qhxxkalGD--------EHWLTFYQXGKFVDpnw-------------vdNei--pTEI-----------IVLQXS 645
gi 74589261   674 -------edssqID--------DLWLTFYQVGKYVSpswfensg-----------------------eqvdlgiLTKQRE 715
gi 169844647  812 -----ttqsllsDDsklreaveVCWIACFQLGRqpe-----------------------------------ypsLDNKMK 851
gi 156842208  588 -------------------svsTYWATVFQVCKFINpn---------------wIdsevpTEYlilqlellgdlLS---- 629
gi 366999090  595 -------------------enkTPWATVFQVCKFSDpnw------------ldnEt---pTEI-----------LVLQFE 629
gi 365991194  627 etsgiatderfnLC--------DYWLTIYQVGKFIDpnw------------ldnEi---pTEI-----------LMQQMK 672
gi 255727665  767 -------pndrrID--------ELWLTFYQVGKYISpe---------------wFdepekt--------idlevLTKQRE 808
gi 254579142  583 ----------knII--------DCWPTILQVGKFVDpnw------------rdgEt---pTEI-----------IFLQLE 618
gi 667787932  617 -----iktrealSN--------IIWKSCLQISKNYEtees-------------------------------lenIKKKMF 652
gi 444322043  610 ---------aesYQ--------KYWETIYLFVKFTDpkwfdinnygdnsrnessDel--pINI-----------IITKLE 659
                         970       980       990      1000
                  ....*....|....*....|....*....|....*....|....*
3K8P_D        646 ILGRLL-EVCP-LEEVEIVTSQWSTLELELSARdLVKDKYALDGQ 688
gi 74589261   716 ILSLTI-LNLQlKENSKVVLAQWMSLNDKIQRHsLENNIEAVKER 759
gi 169844647  852 LLGQAL-DLCP-TDRMHDVLTAWRRMQKE--------DIERREER 886
gi 156842208  630 --------VCP-ADGLDIVVSQWSGAELELSTRnLIDDKYSIENM 665
gi 366999090  630 LSSDLL-QSCP-TEEMEIVISQWSSLELELLTRdIINDQYSIgns 672
gi 365991194  673 ILSKLL-YVCP-VEEVEPIISYWSGLELELSIRdLVNDKYSLEK- 714
gi 255727665  809 ILSLTIaTLSL-GENSKIVINQWQSLNDKIQRVsLENDIDKVKQQ 852
gi 254579142  619 ILGELL-QICP-VDEVEAVASQWSALELELLTRdLIKDPYSLEKs 661
gi 667787932  653 LLSKVI-NICP-KEYLVEVLNVWKRFEKEQLSI-RSKKLSEFNDn 694
gi 444322043  660 IIEELS-NICP-VEESEKVINYWSELELELATRdIIYEAEYIEKD 702
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