3K8P


Conserved Protein Domain Family
Sec39

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pfam08314: Sec39 
Click on image for an interactive view with Cn3D
Secretory pathway protein Sec39
Mnaimneh et al identified Sec39p as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes. Kraynack et al. (2005) showed that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p. This was confirmed in a genome-wide analysis of protein complexes by Gavin et al (2006).
Statistics
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PSSM-Id: 336995
View PSSM: pfam08314
Aligned: 72 rows
Threshold Bit Score: 350.818
Threshold Setting Gi: 74589261
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D          7 YLLACIFASRADTRNIKK-LSTRLG---SQSK----------YLEILCVLW-PELDDPknllflRELEEEVQspegEE-- 69
gi 74589261    15 VYTIQLLTSNNNVHNINAyFRLLSAkvlSSNFdclkittranILKTLLIYSyPLNIPL------QDIIKLAK----LI-- 82
gi 169844647  182 VTSAQNLATQQFFDAIQLmFKKHRSelwPSRF-------------AILDAI-PEHAVP------SSYRHLLP----GL-- 235
gi 156842208    6 YLLCTIFAARADITNSSL-LYDQANgnfTQE-----------CFDALCILW-PELMDP------NGLSFVFQ----QG-- 60
gi 366999090    7 YLLATIFASTADVEKLTI-LKNSFTnssE-------------LLDIICVLW-PELDDP------ILLRNFLT----NLel 61
gi 365991194    7 YLLACVFASKADSTNLSQ-ILRHVHyslD-------------FIKAACILW-PELDDP------MNLISLFP----TI-- 59
gi 255727665  106 VYTIQLVSSSTDIDKLQAfLRLLNAkvlSSDTneftfttknnLLNAILVHTyPLNLEL------EELTKLAN----LL-- 173
gi 254579142    7 VILAAIFAARADSTNCET-LWTFFH---SSDE----------LFDIICSLW-PELDDP------TK----LQ----FLfd 57
gi 444322043    7 YLLTCIFASRGDSLNLKIiLKNEKVngvNFVE----------KLNIVCVLW-PELDDP------S----NLK----FL-- 59
gi 667787932   11 LYIAVQYASAPSLQTLSE-LILKFPyifSKRV----------ILSI-LNFV-PECIDP------DEYLSLIF----DEky 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D         70 ----TTDEDVI------VEl-----------------------Le--sDSSLIPL---IESDTTTRSNRYHEL------Q 105
gi 74589261    83 ----IYSTQSE------IEst--------------------deDg--fDLEEFSLslkSDIANTVSLKATANE------L 124
gi 169844647  236 ----DNATNLElvwpqePWr-----------------------Pe--pDV----------SEQSEIRSVLREI------E 270
gi 156842208   61 ----PSDDQVQ------LSdpndl---------------mmnlLe--vDNKLIPI---IELEHDIVHERSEKV------K 104
gi 366999090   62 ndlnADENPID------EDnil------------------vslLe--tGEDLVPI---IEMDVETVSERVSTV------K 106
gi 365991194   60 ----ELGNDDN------DNnasanddgsl-----sdenlvvklLe--nNPDLIPL---VEVGNTIVNTRYLSTkyfiesK 119
gi 255727665  174 ----IDPSNIT------KTd-----------------------EtdsfDVEEFAFglpTQIENESSLLATAQD------L 214
gi 254579142   58 --psEKSSSGH------STnpqdl---------------lvelLe--tDEQLISM---VEMDSDTITQRRQAI------S 103
gi 444322043   60 ----FTDDEEM------TDdsdlirsydgddiyrnpadlvvniLk--nNEELISI---IESDHNCLNERYDHM------V 118
gi 667787932   68 ------------------------------------------eGe--dDMDSSQIsktQNINNAALSQKLKKL------H 97
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        106 E-------------FI----SKKLNN---KTL-----ENFEEWLRERILICNexiP---ETPLLYSVLWETA-------K 150
gi 74589261   125 LvdtnikcqslgilDF----SAAADNdddDDD-----ELFLSFICAKSFYLSqfyQ---DINDILPLFENVS-------- 184
gi 169844647  271 Vgfnel----vltnDL----PVITEP---LEA-----EALRKWYSNQVDVII---Q---ATGIVDAALAIVQhgasqgiP 328
gi 156842208  105 Dfvsk------rilQL----EQDSLI---TFD-----NILSNWLRRRILVCDefnP---NNVLFNEPLWET--------- 154
gi 366999090  107 Eyi----------nRRlvevTLDEIT---SFD-----DTVSSWLRKRILLCDelnP---FNVLFNKKLW--K-------E 156
gi 365991194  120 Lng----------lYS----SNIIPL---ETSlssleDLQSLWLQIRILVCNeviP---EMTSFYEPLWTHS-------N 172
gi 255727665  215 Mvdtnv----qssyIG----GLKFGS---TPD-----DLLLSFIQAKTIQLSkyfD---NVNDIMPLYERVS-------- 267
gi 254579142  104 Rya----------aEY----MKQVTP---YDRik-fvTPMGDRLRKRLITSN---ElsdQLPMQYHPVWKVV-------S 155
gi 444322043  119 Dyintkl-sviqtlKG----SLDVLN---TEL-----SLKYTWLKNRIILVNnfyP---MDTIFNRTLWSLK-------V 175
gi 667787932   98 Iy------------------qDETKTnncISD-----EELYAWFISRALQIE---E---ETGLISFSRKLVL-------T 141
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        151 SKVL------ST-KFIGW---VEGVLKPLDHLNKRLH------LIFKINEWEKXPDSELFKIIFDGVeDxQGY--I--GI 210
gi 74589261   185 ----------FP-KFNAW---FKGIILP-----YKYYys----------hFGLAYSINTLNSYLAPE--------S--SY 225
gi 169844647  329 GLDE-----------------LGEELSLLSRLVYDTPqaqftnDDWTVSRWRSMSPESVVRAYLAHSpP-ES-------L 383
gi 156842208  155 -HSK------DDiKFAQW---ISGIIKPLSYLNLRsg-----sKTLKIKDFENFKPVDIINLILGNInD-DEYnlS--ID 216
gi 366999090  157 IKPI------DP-EFMGW---VNGILEPLDFINNSsd----irVQFRIIDFEALTPNNVIELLTKNLlE-NEY--SfnNK 219
gi 365991194  173 F-HI------NK-EGKDW---IECIIEPLNYINSRLGs------kLKIKDFSKMDPIAVFPLILE--------------- 220
gi 255727665  268 ----------SD-AFQSW---FAGVISP-----YKYYyd----------hYGQVYNGATLQEYLSA------G--E--TL 308
gi 254579142  156 IKD--------E-ELPKW---IEGIVEPLDHLNKRLNs------sIKIKEFENMDPLSVFDMIL-NTpD-ENP--D--TV 211
gi 444322043  176 FRDKpindqsHS-IFFNW---INGTIYPLYYINQRLNk------TLKIQEFENLKTEDVINMILNSQeT-LKK--E--TI 240
gi 667787932  142 SKYPi-----PP-KVQEWgrgIVSTLESVINRQYNNPll--efNVPTLREFETLNHKEVIDILLQHL----EN--E--EI 205
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        211 ADVIEDELAPTLSYGKKW-----------------------ETFIteffnkqqfsl------------------------ 243
gi 74589261   226 SSRLHLLLGPLKTEKILNneswfknviipiddyygkdlhplNEWLfdnengycskpvesvvrkyq-------fwhvclkc 298
gi 169844647  384 PQDISSLVMPYLYVLEARaeragspd-------pdlpnrllYDYIlsiplehaaavfeask----------------ptl 440
gi 156842208  217 ASIIIQELIPYLKYSKAyd--------------------ifLDIVfnpsvfrfdtavnyynfr------------qlysl 264
gi 366999090  220 NVQQIDCLISYLNYTNsftlfl-------------eqkfntNSFLfkkkqnylvfdaif-------------------tk 267
gi 365991194  221 GGDMKKELIPYLQYTks-----------------------fTSFLnnfctvtqfpmdnqenyel---------ldnlidi 268
gi 255727665  309 KNKFEMLITPLSAGKVSNieqwianviipiimyhnndfrplNEWLfysdmgatvtkgsnktspvtky----svwssciss 384
gi 254579142  212 ---LQRELMPYMANGdy-----------------------yERFLhsflttkdfplntnynfevf-------yqlilslg 258
gi 444322043  241 VN----ELFPYIRYNnc-----------------------fDLYLesffnsdkiqinnlsdyqrfkslfieineeirsff 293
gi 667787932  206 LEEIKSSIIPYISYCQKSsktni--------------wdslWSWLlnfsfkqknlnlikl------------------is 253
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        244 -ksdtnyqlfikLY-------Y---SLEKG---Vkd---nSEASRKLQSNVVDIL-FHNSENLFNLSSLTH-----KLDE 300
gi 74589261   299 ihhhydlkdyqiILnsflsacYfygFKEDT---DsvstieLVEIYDLIIDTITLFdIH------TEELRLPdidykDIPF 369
gi 169844647  441 pasqrvlrddedVArlalaclY---GSESL---Se---------WPTMSRIFECMpAWDTVDEGETDEEAA-----DTTI 500
gi 156842208  265 lsneipiefkekLEelslkiiY------DN---S-----------------ANMLnVTSSSELEQLLTQFS-----P--- 310
gi 366999090  268 fnesnvmadkenFQkaalsiiF------EN---Skel-mnIISM----DELKQLLdAFD--------------------- 312
gi 365991194  269 lpsvlpqdeihtFKtsllriiF------EN---Sg-----------------nLLkFTTLATL----SNLV-----NVTA 313
gi 255727665  385 lnrhfeleefkvIIetylaacYyfsFKEDTdvvSsv---dIMKSYEVIHDTLSLLr--------GSSKTLA-----PGSQ 448
gi 254579142  259 lrgqetnkylerFKrq---caY---ILFKN---Gpny-lnIGTKYRLNQVLLTIGdETPVGDLGITVETL---------- 318
gi 444322043  294 gnldeltsinskFQtnsl------diiLKN---Nkw---lITQ-FKGTKEINELIi------------------------ 336
gi 667787932  254 fnnvissekyseFSkyaiascY---CLQST---Eee---nIHSMKIILQNLKQNLnIE----TNSNTSVLN-----DIKI 315
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        301 LWS----ILS-----GFPDEITIEEqKTITALExKQ-FXEFFIKCSTKF----------SFKEIF-AI-TQEEESAQLAH 358
gi 74589261   370 DC-------------HNLKEFQSAT-NPISPLFqIG-AIAYLRQVIETCqkllp-inrlTIKKYFqLK-YQNKEMDTKRE 432
gi 169844647  501 RALgnfvAPStsrtsCAPKDLLTFF-KPLSIQAlSR-ALDILDVHLESGeilsrwsvpaPLR--WfLR-SHDDVNEQRAW 575
gi 156842208  311 -------GTKvkstsLTANNL-------------KW-FAHYMNLCFQGY----------SLSDINaIC--QSSEQEQLAH 357
gi 366999090  313 --------QNietanGINSKIL------------LS-YIHLISIFLQDY----------SLKEVH-LI-SKENEASQLLH 359
gi 365991194  314 DNS----V------------MLTDY-DNLHYYD-LQkYLLFMQNFSKSk---------dSFKDLY-LI-NKGTESSQLAH 364
gi 255727665  449 DID----YGNipmdcASFNEFNTPS-NPLSALFhSE-CIPELKHAIETCqklfp-inklTLKKYLqFN-YDPSSIDLERE 520
gi 254579142  319 ----------------------------------LA-YSSLTDKLFHGYhmq-----------dlyAI-SKDDESVQESH 351
gi 444322043  337 ---------------RIDHNIEAKK-YGNCFKI-KK-ILRIIENIFHNDit-------ytIDEINdTI-ENNNKEQQVSK 390
gi 667787932  316 SSl-----------nVFTPENIQDY-SELITPN-SD-SLSLLEIMIKTVliinstkeicKITLSEaVCyRNKDKKSQISL 381
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        359 FSSLCH---E--EFnKa---NEISSFLQAXYETVL-----------DisKDDKIFTRI-SXDEKLYSILEILLQXNEFAY 418
gi 74589261   433 ILKITN---N--I---------NASNWKQLLNSIAlfqk-----------nfiFNERI-SATVIERFLLANL-----FDV 481
gi 169844647  576 ANRMAR---R--AGgSvd-pLTTMEDWEWLLEDMLklt------esNesGLRGAFGLL-ARDEVLSIYFSGLLSTGKFDI 642
gi 156842208  358 FASMVK---GkiCNsQs--qQTID-----VISNLIs---------eSkiKEKQIFTNL-TIDKQISIFVEILLELGEFDL 417
gi 366999090  360 YTSMIK---Ak-IMsKg--fKTSSS---TAVNEILsvi-----tgsAsnSEQIVFTHI-PPKRQISVLIDLLLELGEFDL 424
gi 365991194  365 FASICKeelS--ANaNk--pSINNAKIKDIFDSIVh------------eDNDMVLSHL-TIERKISILLETVLDLGEFDV 427
gi 255727665  521 ILRITS---N--INh---------SNWQQLMRSVDlfkssfvseenT-------NGQV-SSIIIERLLFANL-----FDV 573
gi 254579142  352 FASLSR---K--CLeTvvseETTMKELKELLKH-------------GksSNNVIFSRL-SEQKKLSIIIEILLEFGNFSF 412
gi 444322043  391 FTEFLE---N--LMkNgy-sFRIEKLitn---------------seNikDIKFVFNKFeTTEEIERLVIDILMNYREFDL 449
gi 667787932  382 LHKMIP---Q--NPhFl--sKLNDSEWIKLRNNIKwlhd-----------vslIYKNI-PEIEYESFLLYNILRTTKFNL 442
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        419 IEA-II----ERF-DY---SN--NTQIYELLVKFFWHFFNNASN-GLRKEPEXKKASQTLQIIQKHX------SQr---- 476
gi 74589261   482 VDE-VYfekkLGD------IT--VNELYDVVLDKFWDCMNHANS-LNDKSGSLHNAELCLKLFDKLVlekdlaED----- 546
gi 169844647  643 AKA-ML----RGS-HPkisLS--PEVVEDICLKCSRELYDNASS-GNYKIGDMKLAYDCLD-----V------PP----- 697
gi 156842208  418 LQNfVT----LNN-SK---LE------ENVLEKYFWNFFNNATN-GLKSRPEIKKAEKTLQLMD---------VQ----- 468
gi 366999090  425 LQD-LM----EEQ-N--------SQLEEAGLEKYFWHFFNNASN-GLKSRPEMKKAQKTVKLL---L------EQ----- 475
gi 365991194  428 LEE-V-------V-TQ---YK--EKFITKLLLKFFWIYFNNSTN-GSKKSLGMTKCRKVLNLLSLEA------HTkgrqd 486
gi 255727665  574 ADE-LF----FND-SL---LPisTNQFYSLVEEKFWASLNHAVN-LNEKSGLLYNAHQCLNLFDKLVlkkdleES----- 638
gi 254579142  413 LHE-LI----ITY-------Q--YKVNEEVLVKYFWHFFNMASS-GQRHKRDLANAEKLVNLL---L------EE----- 463
gi 444322043  450 VGD-I-----LGS-HS---DE--DSQINDIVIKYYWKTIKKFNNdGTKKNVEMLNIEKILTILKHR--------K----- 504
gi 667787932  443 AEN-IYikrnKGNmP----LK--DVMVEKICIEIFLEFFDSSSN-GNITKGNMKNAYNLLQTIKQYY------NS----- 503
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        477 --AGTnLTKLEVLLEISDKLSHYSINLNKSHngardtAFKPSNILEY---R-DcPLDIISNLLELNPRLYKDLPTTKSLL 550
gi 74589261   547 --NHRdIVKFKHLFKAINALKRFKLL-NRNQ------PYTPQQLIINfanG-N-ILKLINIVLEQNPKSYLAFDKLYRIL 615
gi 169844647  698 --LSDqIQLEKEFIEATSRICSFNVISRAGV------PISPIEIRLT---K-D-RLSLVSQVLSSNSDAYKHTEVMLDLT 764
gi 156842208  469 --NSTvYKHLHTLLKVADTLSRYSINLGKGI------PFKPCNIFEF---KyN-PSKLISILLELNRDLYKDVANSMNLI 536
gi 366999090  476 --NEPkFKHLEILLHIADLLSYYSINLGKGV------IFKPSNIFDF---K-NhPSQIISKLLELNDGLYKDKNTTSLML 543
gi 365991194  487 liTKEeLNSLQTLLDVSDDLSKYSMNLGKGH------IFKPSNILDF---EtK-ETGLISILLESNNSIYKDISVTFEIM 556
gi 255727665  639 --SRQqIVKFKHLFKAMHALKNFKIVIVSSDadr-nkPLTPYALINSfadN-N-VMNLITIVLEQNPKSYLAFEKLYRIL 713
gi 254579142  464 --NAPkYTHLRILLDVTKDICDYSINWGRSL------PFRPSHLLKF---KeD-PFGLISLLLESNRRLYKDVPATYSIL 531
gi 444322043  505 --EVNeYHYLRQLVNNCYELSKYSI--------------KPIDIIQYk--Q-E-PIKIISKMLENNNGLYKEF----EIF 560
gi 667787932  504 --EQ--LESFSYLVKVTNTLYHYS------H------KFKPVQIRLH---N-N-PFEILEDFLSSNPGIYKSIDEVMEIC 562
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        551 FGIYDS---L------------SINREGqTGKVE--VDLXVLHIDYALVNLDFGTAYELGKQVFEIC---------QEAG 604
gi 74589261   616 NDMILFynddnhk----------dgkqhaDNYYF--NKLKTACIESALIDNNFNYAYKQSLELFdyldgk---------- 673
gi 169844647  765 YKLGF----------------------RdDVSAT--VKVLAMLAETALQMEDFTRAFECTQRMVAII---------HDLQ 811
gi 156842208  537 DQLVEAm--Q------------ISREHLdRESEY--NKILVIHIDHALVNMDFTFAFQKSKELLRRD---------SVS- 590
gi 366999090  544 KELFEGm--N------------LDITGDfFVQEQ--IRVSEFHIDNALANLDFYFAYHESKELLTKS---------ENK- 597
gi 365991194  557 KKLNVA---MacqcpfinhnqlKPAQKKdVIVAY--MRLLTLHIDYSLVNMDFNFAYKLTMELFDKFktyigqqseTSGI 631
gi 255727665  714 NDLLIF---F------------GEDGDGeNNFYF--KKLKTACIESALIDNNFNYAYTQSIELFKFF---------EDK- 766
gi 254579142  532 QKLLVA---F------------EIAKQGtTDSEEnlVKVLVLHIDHALVNMDFQFAYENTRDLLKKk------------- 583
gi 444322043  561 NEKVYN---N------------LQIEITnDERIE----IINLQIINSLKNFDFNFAYQMIQDLFANY---------Q--- 609
gi 667787932  563 NDLLLStnkN------------YLy----QKEIQ--AKILCIIAETALSQNEFDFAYDICINHLfslfeavd-------- 616
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3K8P_D        605 QHXXKalGD--------EHWLTFYQXGKFVDpn---wVdneipTEI----------------IVLQXSILGRLL-EVCP- 655
gi 74589261   674 --edssqID--------DLWLTFYQVGKYVSpswfensg----------------eqvdlgiLTKQREILSLTI-LNLQl 726
gi 169844647  812 TTQSLlsDDsklreaveVCWIACFQLGRqpe----------------------------ypsLDNKMKLLGQAL-DLCP- 861
gi 156842208  591 -----------------TYWATVFQVCKFINpn---wIdsevpTEYlilqle-----llgdlLS------------VCP- 632
gi 366999090  598 -----------------TPWATVFQVCKFSDpnwldnEt---pTEI----------------LVLQFELSSDLL-QSCP- 639
gi 365991194  632 ATDERfnLC--------DYWLTIYQVGKFIDpnwldnEi---pTEI----------------LMQQMKILSKLL-YVCP- 682
gi 255727665  767 --PNDrrID--------ELWLTFYQVGKYISpe---wFdepekt-------------idlevLTKQREILSLTIaTLSL- 819
gi 254579142  584 ------nII--------DCWPTILQVGKFVDpnwrdgEt---pTEI----------------IFLQLEILGELL-QICP- 628
gi 444322043  610 ----AesYQ--------KYWETIYLFVKFTDpk---wFd---iNNYgdnsrnessdelpiniIITKLEIIEELS-NICP- 669
gi 667787932  617 iktrealSN--------IIWKSCLQISKNYEtees------------------------lenIKKKMFLLSKVI-NICP- 662
                         970       980       990
                  ....*....|....*....|....*....|...
3K8P_D        656 LEEVEIVTSQWSTLELELSARdLVKDKYALDGQ 688
gi 74589261   727 KENSKVVLAQWMSLNDKIQRHsLENNIEAVKER 759
gi 169844647  862 TDRMHDVLTAWRRMQKE--------DIERREER 886
gi 156842208  633 ADGLDIVVSQWSGAELELSTRnLIDDKYSIENM 665
gi 366999090  640 TEEMEIVISQWSSLELELLTRdIINDQYSIgns 672
gi 365991194  683 VEEVEPIISYWSGLELELSIRdLVNDKYSLEK- 714
gi 255727665  820 GENSKIVINQWQSLNDKIQRVsLENDIDKVKQQ 852
gi 254579142  629 VDEVEAVASQWSALELELLTRdLIKDPYSLEKs 661
gi 444322043  670 VEESEKVINYWSELELELATRdIIYEAEYIEKd 702
gi 667787932  663 KEYLVEVLNVWKRFEKEQLSI-RSKKLSEFNDn 694
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