Conserved Protein Domain Family
cwf18

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pfam08315: cwf18 
cwf18 pre-mRNA splicing factor
The cwf18 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe.
Statistics
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PSSM-Id: 336996
View PSSM: pfam08315
Aligned: 144 rows
Threshold Bit Score: 75.308
Threshold Setting Gi: 219115872
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121791991    6 TLSAASDDRKARLAKLKSLKRKQpteadadetettsqndfvptatttthpndnntqDPPtqdv---arlhLSGRNYDFET 82
gi 758987173    2 SLEEFSRARKHKLSLLRSLRVAEqtnssl---------------------gstsvqASRai--------kRHFRNYDPIT 52
gi 808364453    2 SLEEFSAARKQKLSLLRSLREAEqsstplps------------------ssstslrQASli--------kRHFRNYDPIT 55
gi 388857309    2 SMEAFTQARRAKLALLRARRSAEqsghtpss------------------sssssstPSLli--------kRHFRNYDPIT 55
gi 443898982    2 SMEAFSHARKQKLLLLRQRRNDEqsgqas----------------------lrsndAGLli--------kRHFRNYDPIT 51
gi 1022842068   2 SLQEASDARKAKLAALKKRKLQHdagaptd---------------------------------aadgeetFKFRNYDPET 48
gi 634348316    5 pLQDAAEARKAKLAALKKRKTLHdsgapiss------------------nldldgeHDAaps------dvFQFRNYDPTT 60
gi 575482426    2 gLSEAAENRKERLAALRKQVQQGasttsntngvdtk--------rhrqesdtesavETSas--------aLRFRNYQPET 65
gi 331242372   64 spqsRSISRKEKLNELRKRKLNTqaaedqsnnn--------------snesqetnnKAKkr--------eFKFRNYDPTI 121
gi 667788364    2 SLDQLSLKRKERLNELKKIKNASdsnvtsle------------------nglsndeNLRinkdlgisdlpLSFRNYDPEL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121791991   83 KGPKLGFEAPPTLApg------qATLEEQARDLEEESRRQEAAdadaqqsgGAAIDLFKLQPKRPNWDLKRELALRTEVL 156
gi 758987173   53 GQLKRLTSARDLP----------DTVEKHVDGLERQTIQQDERq------rNEQLDLTNIAPKRANWDLKRDLERRLKKL 116
gi 808364453   56 GQMKRFTSARDLP----------DTVEKDVDGLQQRIISDDEQk------rQEELDLNNIAPKRANWDLKRDLQRRLKKL 119
gi 388857309   56 GQLKRFTSARDLP----------DTVEKDVCGLQAETIAEDEQr------rREDLHLTNVAPKRANWDLKRDLEKRLRKL 119
gi 443898982   52 GQMRRFTSARDLP----------DTVEKDVDGLQQSTLADDERr------rKEDLDLTNIAPKRPNWDLKRDLEKRLRRL 115
gi 1022842068  49 GTARKHARLDEE-----------DTVEKQVEGLTDAAIAQDEAq------rAQELDLTNIQPKKPNWDLKRDLERKLAKL 111
gi 634348316   61 GTARKHARTDEL-----------DTVEKQVEGLADQVIARDEAt------rVQELDLTNIQPKKPNWDLKRDLDRKLGRL 123
gi 575482426   66 D--ALKDYVETAPIvgphakhhvDTVEGQAETIKHDALEAEEAr-------NKELDLTNLAPKKPNWDLKRDLNKKLEKL 136
gi 331242372  122 QGPKRHDPSEHSK----------ETVEETVKDLMEKVKQNDEAi------rSSELDLTKIQPKKPNWDLKRDLTKKLSKL 185
gi 667788364   64 RGPRMGFKNSSLWTe--------ETVEFEAQRLKDNTDSnatk----ipfnSNELDISGLKSNKINCDLKRELLKKNERL 131
                         170
                  ....*....|....*.
gi 121791991  157 HVRTENAIARLVRErL 172
gi 758987173  117 EPADSQATILLIRQrI 132
gi 808364453  120 ERRDKEAVILLIRQrI 135
gi 388857309  120 QRRNKEAAILLIRQrI 135
gi 443898982  116 ERADKQAILVLTRQrI 131
gi 1022842068 112 KPKTELAISQLIRKrL 127
gi 634348316  124 RHKTDQAISQLIRKrL 139
gi 575482426  137 DRKTKKAAANLVRQrL 152
gi 331242372  186 EPITQAAFATLIRRrM 201
gi 667788364  132 KKKTEYAISKLIREkL 147
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