Conserved Protein Domain Family
cwf18

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pfam08315: cwf18 
cwf18 pre-mRNA splicing factor
The cwf18 family is involved in mRNA splicing. It has been isolated as a subcomplex of the splicosome in Schizosaccharomyces pombe.
Statistics
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PSSM-Id: 311976
View PSSM: pfam08315
Aligned: 144 rows
Threshold Bit Score: 76.0734
Threshold Setting Gi: 219115872
Created: 21-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121791991    6 TLSAASDDRKARLAKLKSLKRKQPTeadadetettsqndfvptatttthpndnnTQ-------------DPP---TQdva 69
gi 331242372   64 spqsRSISRKEKLNELRKRKLNTQAa---------------------------eDQsnnnsnesqetnnKAKkr------ 110
gi 343427787    2 SMEAFSAARKQKLDLLRQRRAAEqsgtal----------------------------------pssshdASLli------ 41
gi 758987173    2 SLEEFSRARKHKLSLLRSLRVAEqtnssl----------------------------------gstsvqASRai------ 41
gi 808364453    2 SLEEFSAARKQKLSLLRSLREAEQ-------------------------------SstplpsssstslrQASli------ 44
gi 388857309    2 SMEAFTQARRAKLALLRARRSAEQ-------------------------------SghtpsssssssstPSLli------ 44
gi 443898982    2 SMEAFSHARKQKLLLLRQRRNDEqsgqas-----------------------------------lrsndAGLli------ 40
gi 1022842068   2 SLQEASDARKAKLAALKKRKLQHD-------------------------------Agaptda---------------adg 35
gi 634348316    5 pLQDAAEARKAKLAALKKRKTLHD-------------------------------SgapissnldldgeHDAapsD---- 49
gi 667788364    2 SLDQLSLKRKERLNELKKIKNASD-------------------------------SnvtslenglsndeNLRinkDLgis 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121791991   70 rlHLSGRNYDFETKGPKLGFEAPPTLApgqATLEEQARDLEEESRRqeaadadaqqsggaAIDLFKLQPKRPNWDLKREL 149
gi 331242372  111 --eFKFRNYDPTIQGPKRHDPSEHSK----ETVEETVKDLMEKVKQndea------irssELDLTKIQPKKPNWDLKRDL 178
gi 343427787   42 --kRHFRNYDPITGQIRRFTSARDLP----DTVEKDVEGLQQQTIAeder------rrneDLDLNNIAPKRPNWDLKRDL 109
gi 758987173   42 --kRHFRNYDPITGQLKRLTSARDLP----DTVEKHVDGLERQTIQqder------qrneQLDLTNIAPKRANWDLKRDL 109
gi 808364453   45 --kRHFRNYDPITGQMKRFTSARDLP----DTVEKDVDGLQQRIISddeq------krqeELDLNNIAPKRANWDLKRDL 112
gi 388857309   45 --kRHFRNYDPITGQLKRFTSARDLP----DTVEKDVCGLQAETIAedeq------rrreDLHLTNVAPKRANWDLKRDL 112
gi 443898982   41 --kRHFRNYDPITGQMRRFTSARDLP----DTVEKDVDGLQQSTLAdder------rrkeDLDLTNIAPKRPNWDLKRDL 108
gi 1022842068  36 eetFKFRNYDPETGTARKHARLDEE-----DTVEKQVEGLTDAAIAqdea------qraqELDLTNIQPKKPNWDLKRDL 104
gi 634348316   50 --VFQFRNYDPTTGTARKHARTDEL-----DTVEKQVEGLADQVIArdea------trvqELDLTNIQPKKPNWDLKRDL 116
gi 667788364   51 dlPLSFRNYDPELRGPRMGFKNSSLWTe--ETVEFEAQRLKDNTDSnatki----pfnsnELDISGLKSNKINCDLKREL 124
                         170       180
                  ....*....|....*....|..
gi 121791991  150 ALRTEVLHVRTENAIARLVRER 171
gi 331242372  179 TKKLSKLEPITQAAFATLIRRR 200
gi 343427787  110 EKRLKKLERRDKEAVIILIRQR 131
gi 758987173  110 ERRLKKLEPADSQATILLIRQR 131
gi 808364453  113 QRRLKKLERRDKEAVILLIRQR 134
gi 388857309  113 EKRLRKLQRRNKEAAILLIRQR 134
gi 443898982  109 EKRLRRLERADKQAILVLTRQR 130
gi 1022842068 105 ERKLAKLKPKTELAISQLIRKR 126
gi 634348316  117 DRKLGRLRHKTDQAISQLIRKR 138
gi 667788364  125 LKKNERLKKKTEYAISKLIREK 146
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