Conserved Protein Domain Family
PIG-X

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pfam08320: PIG-X 
PIG-X / PBN1
Mammalian PIG-X and yeast PBN1 are essential components of glycosylphosphatidylinositol-mannosyltransferase I. These enzymes are involved in the transfer of sugar molecules.
Statistics
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PSSM-Id: 336999
View PSSM: pfam08320
Aligned: 104 rows
Threshold Bit Score: 112.398
Threshold Setting Gi: 403167009
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 306 PTGLHPTMTI--SM---PP--SS------LNsPpappD-ATCALHTYLTLPSTIFGDKYQLSTTDPLfldshnlvA---L 368
gi 74854533  383 KSGFHRELVI--NVt-lKSplRD------TVp-------GVCKIMVLENLDQGIFVDRYEVDEIER---------FggpK 437
gi 942200613  47 KDGFHRELLI--DV---EA--GG------AA-G----VpEGCSLALVVHLPKGVYVDPYQLAMLKES--------N---E 97
gi 195999306  68 leGFHRDLIT--KI---NF--RSevksnlTS-F----S-DQCSLLLVERLPTGIYVDLDQVAEMERL--------LkdiS 126
gi 330804076 366 KSGFHRELVS--NVtikSP--PT------LK-I----P-RECKLLFLEHFDQGIFVDRYEVDEIERF--------Gg-pK 420
gi 260809065  75 NHGFHRDVVTevTL---PV--AM------VT-P----P-MSCRLLLVETVPAGMYVDLHQVTFRTDF--------Gg-pQ 128
gi 954374348  34 gDGFHRQLSN--FI---YL--SS------MN-R----L-VNCSVVYRVTVPSGAYLDVDQMPASIR---------N---M 82
gi 541040910  41 gAGLHRRLIV--DA---SL--GS------SN-R----F-IDCQFAYRFVIPAGAYIDMDSVPPLRDH--------H---I 90
gi 351694919  17 KDGFHRDLLI--KVk-fGEstED------L---------QTCRLLIKQSIPTGLFVDPYELASFQEK--------NiteA 70
gi 395519213 113 KDGFHRDLLT--RVk-lGTnvEN------S---------QTCNVLIKYHLPSGLYVDPYELASLQEH--------NvteA 166
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 369 H--AVAGETDLEAPDWFVSRWGSNWLLELATP---SESDQVPEEWNVTIPLHLRYLRP----S--E-S--GYRSASVPWP 434
gi 74854533  438 V--VIYQLIDLEKPSTSSTQN--FVSI----IkqfNTTGSATQDIQLTLPIHLRYQNPlfsdNgdS-N--TFRQSIISSP 506
gi 942200613  98 LeaLVLNEVDVEAPEYFSSE--VSVLV----Ft--KRSSQCIGCFTSTLPLHARYHRP----St-G-Ge-THVTVILGNP 162
gi 195999306 127 V--ISSDRIDVEKPAHLSTEHLLLVYARINPI-------TDVRSTKVSLPIHLRYHLP----Qd-DwY--GYTEVVMPRP 190
gi 330804076 421 V--NIYQLIDLEKPSATSTQN----YISVVKEf--TVNSEPEQTIQVTLPIHLRYQNPi--nSn-Q-D--AYRNTHISSP 486
gi 260809065 129 V--LALSDIDVEQAAHQSSHHRLLLYSPL-------QQNPKGFTWRVTLPVHLRYHRW----Ag-E-GedTSATVRLEGP 193
gi 954374348  83 F--YSYKPFFVEAPAWTSVDQ--TVLIESSk----RMYNAFIFEDVIEFPIHFRYQKP----Tk-G-G--LIVKVRFYAP 146
gi 541040910  91 A--HVY--FDTEVPKERSTDTP----VYICSKr--ALRKNFVFNDHLELPFHLRYHKP-------T-G--NDAIVKFSPP 150
gi 351694919  71 V--MVSENFNIETPSYLSKES--EVLI----Ya--RQDARCADCFQAFLPVHYRYHRPh-----sE-D--AETLIVVGNP 132
gi 395519213 167 M--IIQDSVDLEAPDYLSEEL--DVFV----Ya--KSDSQCSECFRTILPVHCRYHQPk-----eK-E--EKTFVVVKNP 228
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110815899 435 VV-FWAC--TAE----------D----GTK------MGVNPFDRVNLGWEGLFGTRTMFYQLHPSS---D----R----- 479
gi 74854533  507 QI-YLSCepTNS----------V---------------------------------------LNNN---DnsnnDnwnli 533
gi 942200613 163 QL-MTRCqtVPV----------DlecpESV------VKEAACTAENKTS-------CNWLLVNYKH---V----S----- 206
gi 195999306 191 MLiLIHCdkELP----------Ef--qCQP------KYTAPCSNSNKSS-------CVWNLLYDNEnedS----G----- 236
gi 330804076 487 MI-FIQCepTNS----------V------T------ESKSTFD----HWKLITSFSPLFEH-------------T----- 521
gi 260809065 194 DV-LMHCegDRPvtt-----pcE----ESR------LFPAPCDAESRGV-------CLWQLLKGKA---E----P----- 238
gi 954374348 147 DV-LLRCldPKFldllnftggaD----DSR------LVEAPC---NFYYNYTSTLLCLYLHVKESS---V----S----- 200
gi 541040910 151 RL-LVKCveNAT----------I----LSEknctkfIRKAPCDCLSDA-------KCDWVILAAK----E----S----- 195
gi 351694919 133 DL-LMSCdqEFP----------VlscwAQS------EVAAPCALKSKnv-------cqWSCLKYQP---Ihk-------- 177
gi 395519213 229 EL-LVSCynDFP----------SlncwKES------DMEAPCSVRNKhi-------cqWSKVKYKS---Vnq-------- 273
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110815899 480 -----------LVEELEVPVLQLDdkgffQSKAIELGTMIVIGLGSLWVLWKL 521
gi 74854533  534 tnynlllddisKSISINVPVGQLN-----DNDSVKFYTLLVTVIGSILERPHH 581
gi 942200613 207 -----------EGAAMEIPVGQER-----RVVVVAAGTLLVTTLCCGLVLGAV 243
gi 195999306 237 -----------NEIILKVPVGIVK-----HGVLVSIGTIISAIAGTIILIIAI 273
gi 330804076 522 -----------KSLFIDVPVGQLK-----DLESVKFNTLTVTVIGSILVIATI 558
gi 260809065 239 -----------LL--FQVPIGQQS-----HAVLVITGTTAVAALGSLLILVAa 273
gi 954374348 201 -----------Y-ADIDIPTPDIS-----YKVPVTIGLILCIIYSFCTTVYTL 236
gi 541040910 196 -----------APIEMLVPTGNPA-----IRSFVIFVTFAFIFGGMCVIVYFL 232
gi 351694919 178 ------------nvTLHVPVGLSI-----HSSLVCSVTLLITILCSTSILVAV 213
gi 395519213 274 ------------nvTLQVPVGLRE-----HCLLVCAMTLLVTVLCSVFILRAV 309
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