3PSP,3EBB


Conserved Protein Domain Family
PUL

?
pfam08324: PUL 
Click on image for an interactive view with Cn3D
PUL domain
The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.
Statistics
?
PSSM-Id: 337001
View PSSM: pfam08324
Aligned: 186 rows
Threshold Bit Score: 64.6529
Threshold Setting Gi: 930408679
Created: 24-Mar-2017
Updated: 23-May-2017
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       180 KQYLIMEn-YNPDTIFNGIVKI-NSne-----------ktFDD-----------------------EILA------QIGG 217
gi 74682652  356 kraitvsnlPNYPALLNKLEGF------------------LADkgktesfmvlknevvpflegkslSETEla---aLLQK 414
gi 296420081 302 mNPVIFTkvPPLDKVIEKLGPT-GKnpvvvs---irdfitLRD-----------------------SQGA-------IEA 347
gi 396476859 316 qrsITFTkvPPLSKVVAKMGEV-GK-----------------D-----------------------PAVS------SIVS 348
gi 353238437 317 lNPILFTqiPKLDALSTKLLSA-VEtsplpvadrgntkeviaN-----------------------GMIR------SLSS 366
gi 930408679 229 tNPITATatPNFTALFGKLEGF-------------------AGaagkqhvdvlknevvpflegkggDAVG------VVDK 283
gi 748510532 317 qppvTYSrqLPLDKVLIKLGKVgTEgpv----------iaMKDfiv-----------------tkqKQGAiearvpDLQK 369
gi 748480360 319 qapVKYTrqLPMDKVLVKLGKVgTDenv----------vaMKNfit-----------------tkqKQGAiearvpDLQK 371
gi 636589011 315 QRPVRFTkvPPLEKVVAKMGDAgNDpsv----------taIVNyiq-----------------vreKSGAieapltELPK 367
gi 330933903 300 qRPVKFTkvPPLEKLVAKMGDLgHDpav----------ssIVSfiq-----------------areQSGAieapltKLPQ 352
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       218 A-------LHDIdeswel---------llsfaNTIRSNW--EIKTPAYDIVRLIVK--K--------------------- 256
gi 74682652  415 W-------SAAT--------------------QDLLPALqpTETFPLIDLWRIALQ--Cqpiipfiglglstassnaepi 465
gi 296420081 348 P-------LQQLsdwa-------------tflRESFTGLptATLFPLADLFRVVLS--Dhrvsgwfaeekgnttik---- 401
gi 396476859 349 F-------IEAReksgaieaplgklpqfaeflRKSTSLLspELLFTAYDLFRVALT--Dirvagffaeehkgatgtpat- 418
gi 353238437 367 IpngktptANSTkvpetef------snwtsvtVQLAAVLppTDFFPLVDLWRLALLipD--------------------- 419
gi 930408679 284 W-------TAAS--------------------GALLQSLkpAEVFPIVDLWRLGLL--Ndgvvrvltprvggpsdpiap- 333
gi 748510532 370 W-------SSFL--------------------QASFKELplETLFPLVDIFRLSLT--Dprisayyaeerghati----- 415
gi 748480360 372 W-------SKFL--------------------QSSFQELppETLFPVIDIFRLSLT--Dprvsafyaeepqhati----- 417
gi 636589011 368 F-------AEFL--------------------RKSTYSLpaELLFTALDLLRIAIT--Darvagffaeehkgamgtpat- 417
gi 330933903 353 F-------AAFL--------------------KNSTSVLppEILFTALDLLRISLT--Dirvagffaeehrgatgtpat- 402
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       257 ----------------------Lpyssdikdyie----------eglgnknitltMLTVRILVNCFNNENW-GvKLLEsn 303
gi 74682652  466 tsiislasntfssspeaipkpfI--------------------------------LTVLRLLTNFTSCVEL-T-NLVLah 511
gi 296420081 402 ------amlsyvtnhtsvpyplR--------------------------------LVTLQATCNLFTSPLF-P-AHLTs- 440
gi 396476859 419 ---vhhllqhvnalgetapyylR--------------------------------LTNLHLSCNLFTSPLF-I-PHILs- 460
gi 353238437 420 ----------------------VstqlatspiislptifkissesasspdaknltLTALRLACNIFVNPVLtR-RLLQss 476
gi 930408679 334 --ilaltakelkqgvaatprplL--------------------------------LTTLRLETNLLAPLPL-A-TAAL-- 375
gi 748510532 416 ------qalletassekaiyqlR--------------------------------LVTLHAICNLFSTPLF-P-PHLIr- 454
gi 748480360 418 ------ealldtalsakgiyqvK--------------------------------LVTLHAICNLFSTKLF-P-PSLTn- 456
gi 636589011 418 ---vfhlldhvdklgegapyplR--------------------------------LTTLHLACNLFSAPLF-I-PHILs- 459
gi 330933903 403 ---vhyildhvdklgesapyplR--------------------------------LTTLHLACNLFTSPLF-I-PHLLs- 444
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       304 q--vykSIFETIDTEFSqaSAK-Q---SQNLAIAVSTLIFNYSALVtkg------------------nsD------LELL 353
gi 74682652  512 d--gnvSTSEQLISVLV--ESL-Ly-pDVGVRSAAAGVAFNIGLWRhhnvv--------------eetpNvd--weLEVV 569
gi 296420081 441 -----pSLSHLVTSLITtsLLDkS---HINARVAAASLAFNLATHVqkqr----------------avyNeevlqdVEFI 496
gi 396476859 461 -----hPLSETLISILTtaLLDdK---HPALKTSALSLAMNIASANhrirmrkhgan-tdpatpeaaelPvp--eqVELL 529
gi 353238437 477 pandgsRPRDAITNLLVsaLLS-D---VATVRVAAASLAFNIAAFLqaplmqslnrgmsgtpikedsldDae--weVELL 550
gi 930408679 376 ------ARPDDLLSVLV--EAL-Lh-pDVGVRKAAADVAVNAAAWRhrvreatpq------tpdapeigGed--weTELL 437
gi 748510532 455 -----aPLVALVIGLVT--TCL-LdesHSQLRVAAASLIFNLAAYNqksrvessa-----tvadridalSdd--dqIQLL 519
gi 748480360 457 -----aPLVTLVLGLVT--GCL-LdesHPQLRVAAAGLIFNLASFNqklrtesas-----tvadredsiSed--dqIQLL 521
gi 636589011 460 -----pPLSSTLISILT--TAL-LdekHSALKASALTLAMNITSSNhqirmkqysan-pshslpsaselPds--eqVELL 528
gi 330933903 445 -----pPLSSTLISILT--TAL-LdekHAALKASALSLAMNISSSNhqvrmkkysan-ssrslssecelPes--eqVELL 513
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       354 PIVADAINtkygpleEYQECEEAAYRLTVAYGNLATv-------EPT---LRQFANSVTWLANI-K-----RsygnvpR- 416
gi 74682652  570 SGLVEALD-------R-EEDEDVAHRLLAALALEIYlspsyednVQP---MLQVLEASNKIEKRcKvwk-------rkE- 630
gi 296420081 497 AAIVEALK-------EERDSKEVVKGLALAVSLVSYcapl-ggeILE---LLKVLEAGGVLSEKaK-----AgmgekaL- 559
gi 396476859 530 ASLLENLS-------ADGQWSDDKKMGLIATGWLVYgadv-egeLRD---TWKVMDAAGTVDKL-------QprsgedRl 591
gi 353238437 551 SAVIEAID-------RE-DNEDSLHRLVSCLGLLVHls----phLAEiqpLLEVLQVKQTLVVKaQpdgpiKkenvkkL- 617
gi 930408679 438 SALVEAIA-------R-EEDSDTGHRLLVAAALVMYlnpgwdegIQP---LLEVLGARDTIDKAaRrwn-------nkD- 498
gi 748510532 520 ATVVESVD-------ReKESTEALRGLILSLGLIVYgakv-dgeVLE---LVGVLEAARIIDEKgKkse-------kkL- 580
gi 748480360 522 AAIVESID-------ReNESTEALRGLLLSLGLIVYgaki-dgeVLE---LAGVLEAARIVGEKgKksd-------kkL- 582
gi 636589011 529 ASLLENIS-------TeEQWSDNKKMGVISVGWLVYcadm-sgeVRD---LWRVMDAAGTLGNVdA-----KmaedrmL- 591
gi 330933903 514 ASLLETIS-------TeEQWSDNMKVSLICVGWLVYaadm-ngeLSD---LWKVVDAAGTVGKAeA-----Kmaedrllv 577

                 ....*...
3PSP_A       417 -FKDIFDD 423
gi 74682652  631 -VKKVGEE 637
gi 296420081 560 -CQEVAKl 566
gi 396476859 592 lIKEVkgl 599
gi 353238437 618 -VKEVTNE 624
gi 930408679 499 -IRKLADE 505
gi 748510532 581 -LGDdgar 587
gi 748480360 583 -LGEdgar 589
gi 636589011 592 -VKEVksl 598
gi 330933903 578 kevkslle 585
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap