Conserved Protein Domain Family
PUL

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pfam08324: PUL 
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PUL domain
The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.
Statistics
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PSSM-Id: 311983
View PSSM: pfam08324
Aligned: 186 rows
Threshold Bit Score: 72.2958
Threshold Setting Gi: 930408679
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       180 KQYLIME-N-YNPDTIFNGIVKIn----------sNEKTFD---------D-----------------------E----- 210
gi 74682652  355 pkraitvsNlPNYPALLNKLEGF----------------LA---------DkgktesfmvlknevvpflegkslS----- 404
gi 74850855  219 SKSVLFE-K-SDVEAVFNKLKEFankefkgkeneqLLITQY---------E-----------------------K----- 259
gi 296420081 302 mNPVIFT-KvPPLDKVIEKLGPTgknpv--vvsirDFITLR---------D-----------------------S----- 341
gi 528300966 300 nQPVSFA-KlPPLEKLKVKLGSFsqee-----gvqQILHFI---------S-----------------------Trsesy 341
gi 748480360 319 qaPVKYTrQ-LPMDKVLVKLGKVgtde-----nvvAMKNFIttkqkqgaiE-----------------------A----- 364
gi 353238437 317 lNPILFT-QiPKLDALSTKLLSAvets-----plpVADRGN---------T-----------------------K----- 353
gi 330794406 226 yKPVLFE-K-SDVDAVFIKLASFanee-----fkgISEKIK---------E-----------------------F----- 261
gi 930408679 229 tNPITAT-AtPNFTALFGKLEGF-----------------A---------GaagkqhvdvlknevvpflegkggD----- 276
gi 331219910 338 psPILYP-QvFNFEKALNKLLDSfps------dsnSPREVI---------Kqtfewvv---------ipflnnkT----- 387
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       211 ----ILA---Q------IGGA-------LHDIdeswel---llsfaNTIRsNW--EIKTPAYDIVRLIVKKlp-ysSDIK 264
gi 74682652  405 ----ETElaaL------LQKW-------SAAT--------------QDLLpALqpTETFPLIDLWRIALQCqp-iiPFIG 452
gi 74850855  260 ----ESN---Q------LKQI-------MKSVdvdtpisietlkyfDGLLsTFsdDHQFPLLEILRMLLLKnq-snQYYT 318
gi 296420081 342 ----QGA----------IEAP-------LQQLsdwa-------tflRESFtGLptATLFPLADLFRVVLSDhr-vsGWFA 392
gi 528300966 342 thniSLP---D------LDSF-------NKSVen--------------sLsNLapLDLFAIVDLLRVCTVDqk-lyISYT 390
gi 748480360 365 ----RVP---D------LQKW-------SKFLqs--------------sFqELppETLFPVIDIFRLSLTDpr-vsAFYA 409
gi 353238437 354 ----EVI---AngmirsLSSIpngktptANSTkvpetefsnwtsvtVQLAaVLppTDFFPLVDLWRLALLIpd-vsTQLA 425
gi 330794406 262 ----EIN---Sp----kLQQI-------IKSTneniivpielckylEQLLkSFsePHQFPLLEILRMLLLKdq-pnKYFT 322
gi 930408679 277 ----AVG---V------VDKW-------TAAS--------------GALLqSLkpAEVFPIVDLWRLGLLNdg-vvRVLT 321
gi 331219910 388 ----DLNspdR------FLQW-------ARAT--------------TQVLdSLgsSDSFPALDFLRLAVLReeyvdQLFI 436
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       265 DYIEE-----GL------------------GNKNIt----------------------lTMLTVRILVNCFNNENW-GvK 298
gi 74682652  453 LGLSTassnaEPitsiislasntfssspeaIPKPF------------------------ILTVLRLLTNFTSCVEL-T-N 506
gi 74850855  319 NQSNP------Iisnillkiq------------------------------skklskpsELLSFRVINNCFFSKSG-I-N 360
gi 296420081 393 EEKGN-----TTikamlsy-----vtnhtsVPYPL------------------------RLVTLQATCNLFTSPLF-P-A 436
gi 528300966 391 GEKGQ-----KTiasllsy-----vnslenCPYSL------------------------RLVTTQLACNLFTNYSH-S-L 434
gi 748480360 410 EEPQH-----ATieall--------dtalsAKGIYq----------------------vKLVTLHAICNLFSTKLF-P-P 452
gi 353238437 426 TSPII-----SLptifki------ssesasSPDAKn----------------------lTLTALRLACNIFVNPVLtR-R 471
gi 330794406 323 DLSNE-----Tisnlm---------ksilkKKLSKa----------------------sELLSYRVINNCFSSKSG-I-A 364
gi 930408679 322 ---PRvggpsDPiapilaltakelkqgvaaTPRPL------------------------LLTTLRLETNLLAPLPL-A-T 372
gi 331219910 437 ------------------------------CPPDSnplyeairignsqslkgtqlarpfSLTLLRLLSNGLGAPKL-A-E 484
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       299 LLES-------------Nq--vYKSIFETIDTEfsq-asaK-QSQNLAIAVSTLIFNYSALVTk---------------- 345
gi 74682652  507 LVLah-----------dG----NVSTSEQLISVlve-sllY-PDVGVRSAAAGVAFNIGLWRHhnvv------------- 556
gi 74850855  361 YLFNgngndnnndnlniV----IESTIDALH---------S-MDKILKRAVSTLAYNLSIHLSi---------------- 410
gi 296420081 437 HLTS-------------------PSLSHLVTSLittslldK-SHINARVAAASLAFNLATHVQk---------------- 480
gi 528300966 435 SFYS------------------FPSMIGSIVQLvttglldE-QNTNVRVAAAGLAFNISRIARtirl-----------ee 484
gi 748480360 453 SLTN-------------------APLVTLVLGLvtg-cllDeSHPQLRVAAAGLIFNLASFNQklrtesa-----stvad 507
gi 353238437 472 LLQS-------------SpandGSRPRDAITNLlvs-allS-DVATVRVAAASLAFNIAAFLQaplmqslnrgmsgtpik 536
gi 330794406 365 YLFS-------------D-----NNINDTFE-Cvid-glhS-KDKILKRAVSTIAYNCSIYLTs---------------- 407
gi 930408679 373 AAL---------------------ARPDDLLSVlve-allH-PDVGVRKAAADVAVNAAAWRHrvreatpq--------t 421
gi 331219910 485 QMIere---------tqN----EGQFLRFVVGRlld------gdvDVQVLASGVFYGLVSRWAsirvdw-------qdtr 538
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3PSP_A       346 --GN--S--D------LELLPIVADAIN-TkygpleeyQ----ECE-EA-----------AYRLTVAYGNLATv------ 390
gi 74682652  557 ---eetP--Nvd--weLEVVSGLVEALD-R--------E----EDE-DV-----------AHRLLAALALEIYlspsyed 604
gi 74850855  411 -dNS--N--Hqe--qaISLLGAIEHILS-Esd----fsN----EDP-EI-----------SFRLLMALGTLIYc------ 456
gi 296420081 481 --QR--AvyNeevlqdVEFIAAIVEALK-E--------E----RDSkEV-----------VKGLALAVSLVSYcapl-gg 531
gi 528300966 485 kqAV--P--Tea--qqVELVASLLEAISlE--------E----TSP-EA-----------LKGYLLALSNFSFcvpp-ds 533
gi 748480360 508 reDS--I--Sed--dqIQLLAAIVESID-R--------E----NEStEAlrglllslgliVYGAkid------------g 556
gi 353238437 537 edSL--D--Dae--weVELLSAVIEAID-R--------E----DNE-DS-----------LHRLVSCLGLLVHlsph-la 584
gi 330794406 408 --NY--Neq------nLSLLTAVSHVLS-E--------IdlstEDP-EI-----------VFRLLMTVGTLVYcnd---- 452
gi 930408679 422 pdapeiG--Ged--weTELLSALVEAIA-R--------E----EDS-DT-----------GHRLLVAAALVMYlnpgwde 472
gi 331219910 539 pvDRagS--Eee--weVESMSALVESLD-Reak---ktE----PNS-EM-----------IYRLIATIGKLIYlses-ss 593
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
3PSP_A       391 -EPTLRQFANSVTWLA-NI-K-R----SYGNVP-RFKDIFDD 423
gi 74682652  605 nVQPMLQVLEASNKIE-KRcK-------VWKRK-EVKKVGEE 637
gi 74850855  457 -------NDDLVEILK-TLdF-DfnkyLNSKEL-KISQLIKE 488
gi 296420081 532 eILELLKVLEAGGVLS-EKaK-A----GMGEKA-LCQEVAKl 566
gi 528300966 534 eLVALLNVMEAQNIV---LsK-L----QQFQEP-LVDEVeki 566
gi 748480360 557 eVLELAGVLEAARIVG-EKgK-K----SDKKllgedgarlcl 592
gi 353238437 585 eIQPLLEVLQVKQTLV-VKaQpD----GPIKKE-NVKKLVKE 620
gi 330794406 453 ------esLDILSTLEfDYnK-Y----LKSPED-KIKKLIKE 482
gi 930408679 473 gIQPLLEVLGARDTID-KAaR-------RWNNK-DIRKLADE 505
gi 331219910 594 sLQTLLESLGFQSIID-GLmNn----pGLLKANpAIKDLGKE 630
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