Conserved Protein Domain Family
WLM

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pfam08325: WLM 
WLM domain
This is a predicted metallopeptidase domain called WLM (Wss1p-like metalloproteases). These are linked to the Ub-system by virtue of fusions with the UB-binding PUG (PUB), Ub-like, and Little Finger domains. More specifically, genetic evidence implicates the WLM family in de-SUMOylation.
Statistics
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PSSM-Id: 311984
View PSSM: pfam08325
Aligned: 18 rows
Threshold Bit Score: 209.496
Threshold Setting Gi: 74692966
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635196  121 PAPSEYCFDKivplDWlPEKERALELLTRLSKDrgVIAVLQKYKWRIGVLTELDPASNTnsdhqgterLLGLNRNKGQVI 200
gi 75136275  139 FCDFRTLHLPgi-eLN-PPPSEALKRMHMLACDpgIIAIMNKHRWRVGIMTEMAPVGYVgvs---pkcILGFNKNMGEEI 213
gi 75161521  144 FGDFRTLQLPgi-eLN-PPPSAALKRMHMLAADpgIIAVMNKHRWRVGIMTELAPVGYVgvs---prcLLGFNKNQGEEI 218
gi 74598500  137 SNNYTFHTLKpl-pYL-PNPARSLQFLTRLRDDpgIRSAMAKHRFSVPLLTEMDPAEHTtse----srTLGLNRNKGEVI 210
gi 74863729   11 YKVHNIKVLN-------KNDKKAKAILSRAAEQ--VLPIMKKRRFRVELLSEFLPKNPN---------LLGLNIVKKSEI 72
gi 74586915   18 PPPANIKKIGal-kRF-SDEAYAKSLLYDAARL--VAPIIHEQKFKVGKLYEMYPDKAE---------LWGLNVNHGQKI 84
gi 74610059    4 PHIRNIAVLQ----RK-PGKEDALKLLKDIADA--VSLLMRENKFKVGTLVEFYPRDRS---------LLGMNVNHGQKI 67
gi 731718     27 PHIQKVAVLQ----SK-PNKEDALNLIKEIAHK--VSYLMKENHFKVTNLVEFYPRDQR---------LLGMNVNHGSKI 90
gi 74632165    2 EFISNITVLK----KR-PGSEAALEMITRAARF--VQPIMKNHGFKVGTLCEMFPKHAN---------LLGLNVNHGQKV 65
gi 159131387 137 ntytfhqlLPl--sYL-PNPSRSLEFLARLRDDpgIRAAMAKHRFSVPLLTEMDPAEHTtse----srTLGLNRNKGEVI 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635196  201 ELRLRTDNY-QGWRNYYNVRNVLCHELAHNVYSDHDDQFWRLCKLLEKEVVELDP----------FGKEGNTVGGTAVST 269
gi 75136275  214 SLRLRTDDL-KGFRKYESIKRTLLHELAHMVHSEHDANFFALNKQLNDEAASLDWt----------KSRGHVLSGRKIFD 282
gi 75161521  219 SLRLRTDDL-KGFRKYQSIKKTLLHELAHMVYTEHDEKFYALDSQLNKEAESLDWt----------KSRGHTLNGTKFIN 287
gi 74598500  211 ELRLRTDAY-DGYRDYRTIRRTLCHELAHCVFSDHDRDFWDLTKQIEGEVERGDY-----------RSGGRMAGGDEFYN 278
gi 74863729   73 KIRLRKTKG-GEIFHFNDIMGTLLHELVHIVHSRHDKSFYELLDKITWEYNELYV----------YNKKGISGGDKVSTN 141
gi 74586915   85 YLRLREHHNdKSFLPMGDIVGTLLHELTHNLYSAHDSKFYKFLDKLKSRYDDIHCrgaktkylceENKVGRGVLLSGSLV 164
gi 74610059   68 MLRLRDPLDeFRFLPWESLIGTMLHELTHNLHGPHDQKFYSKLDELSGRQWCIQQlgl----kdnFMTSGNRLGGRGFRD 143
gi 731718     91 MLRLRCSTDeFQFLPMECIMGTMLHELTHNLFGPHDKKFYNKLDELIGRQWVIEQrgl----ydtFLGNGQRLGGRANLR 166
gi 74632165   66 CLRLRQHYDdKMFLPFESIMGTLLHELCHNKYGPHNAQFYAYLKELEDDYYALKArgfnpdtpygFLGPGKTLGSGGGR- 144
gi 159131387 210 ELRLRTDAY-DGYRDYRTIRKTLCHELAHCVFSEHDRDFWDLTAQIEKEVERADW-----------KHGGRRLTDEEFYN 277
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74635196  270 TSGpyqewlEMDSDEDVGDSGGWHGGTYVLGrGRNEvqq--------------------------------------eke 311
gi 75136275  283 S-----------YEDEFVLEPDSVVVGHKLG-GGS--------------------------------------------- 305
gi 75161521  288 D-----------DDEEDYFFDENETVSQRLG-GNQS-------------------------------------------- 311
gi 74598500  279 PSDw----eVEREGGHVVDGGGVVGSSQVLG-GNSQv------------------------------------------g 311
gi 74863729  142 I------------IKYNLGRNNIMKDNIILD-ITKMnnv---------------------------------------is 169
gi 74586915  165 SV--------REQRLKELSKPKFANESKVLG-SNSKink--------------------------------------pig 197
gi 74610059  144 GPT------PRTTNSRGNKIEKIRNKGVRLG-SLSDnlng------------------------------------slnt 180
gi 731718    167 SNRy-----PMTGISTNTGIVRKRGKGVKLG-SLHPegi--------------------------------------ssi 202
gi 74632165  145 K-----------LNGPASGIAGIPGLGAGPG-GRALpktnvtlspskvvkpktgrqkrftgtgnvlgsstpspppvpgrr 212
gi 159131387 278 PGDw-----EREKDAAVVDERGWTGGEFVLG-GLRDe------------------------------------------s 309
                        250
                 ....*....|....*....
gi 74635196  312 DKNKSIRELLQRAAERRQQ 330
gi 75136275  306 SSLASARVLSGSAAYKRFL 324
gi 75161521  312 DNLGNARESSVAAAYRRLS 330
gi 74598500  312 ASGGGMREVLARAAEERAR 330
gi 74863729  170 ICEENPKFMAAQAAEKRLL 188
gi 74586915  198 GSPRDLRQAILEAAERRLR 216
gi 74610059  181 SRMLKPAQMAAMAATRRAE 199
gi 731718    203 DRGNSPRELAAFAAERRYR 221
gi 74632165  213 RPRAPTREQILAAVEKRIA 231
gi 159131387 310 SGVESRREIIARAAEERMR 328
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