1X53,2LAK,3Q63


Conserved Protein Domain Family
AHSA1

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pfam08327: AHSA1 
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Activator of Hsp90 ATPase homolog 1-like protein
This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family.
Statistics
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PSSM-Id: 337003
View PSSM: pfam08327
Aligned: 96 rows
Threshold Bit Score: 56.9365
Threshold Setting Gi: 81375095
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1X53_A        21 TSPEELYRVFTTQELVQAft------haPATLEADRGGKFHMvd-------gnVSGE--FTDLVPEKHIVMK-WRFK--S 82
gi 81617753   32 VPLEKLFAAFSSAEALKRwwwpegiyadHIDWELRDGGKYFInmkgydqsasgMAGW--IEEVVKNERIVMTdQFAN--E 107
gi 81464845   14 YPLMRVWNAVTVNEELIHwl------adKVTGRPKEGANFAWtwrlgmegdltTNGI--YKKIIPFKELILL-WQDH--- 81
gi 74873287   11 VPPEVLFNAFTDAYTLTRlsr-----gsLAEVDLKVGGKFSLf---------sGSILgeFTEITKPHKIVEK-WKFR--D 73
gi 74776698    3 VPPRVLYNSFLDESDLTRlsl-----gsKCLMDPKEGGKFSLy---------nGSVEgtNISLDKDTRIEQN-WRFS--S 65
gi 74799767  230 CRANELFDALTREDMVTAft------rgHVKHELFKGGDFVYf---------gGNISgkFEEIVQNKKIVQT-WRYK--Q 291
gi 74867914  230 CSANDLYNALTKPEMVTAft------raPAKVDAVRGGEFILy---------gGNVLgkFEELVPEKKIQQS-WRLK--N 291
gi 74687776  210 ASADDLWGLLTDENKIPMws------rsAAKLSLKAGSPYELf---------gGNVRgkVITADPPKKLVQT-WQVKspS 273
gi 48474991  216 APANELYATFLDPARVAAws------raPPQLDVRPQGAFSLf---------hGNVVgkFLVLEENKKIVQT-WRLS--S 277
gi 268559430 221 ATPERVFEAITETQLVRGwtn-----gsIQEWDFKEGGKFALf---------gGNVTgtFEKIEPSKEIVKK-WRLK--K 283
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1X53_A        83 WPEG-----------H--FATITLTFID-KNGE--TELCMEGRGIPAPEEER-------TRQGWQRYYfeGIKQTFG 136
gi 81617753  108 KGEPisakeanmpgeWpaKGYITFEFESrGKDR--SAFRLSQEGIPNELQAE-------CIQGWAESFe-KLKKYLA 174
gi 81464845   82 -Pa--------------gEIELKLEFHSlGEDS--SKLVVTNSGYPVGDKYDvwi--eaASEGWEEEGk-HLREYLK 138
gi 74873287   74 WNEc-------------dYSTVTVEFISvKENH--TKLKLTHNNIPASNKYNeggvlerCKNGWTQNFlhNIEVILG 135
gi 74776698   66 WEEg-------------vYSKVVIEFRPlIGEDdcTEVVLVQTGIPSLDKFGnpgcleqCMLGWERNFwdRFEKIMG 129
gi 74799767  292 WPSg-------------hYSTVTMELEE-KEDH--TELNLTQTMIPAAELET-------TKQNWQRYYwnSIRSAFG 345
gi 74867914  292 WTSg-------------hYSNVVIELEE-TSSS--TMMSLKQTGIPASEFDA-------MKTNWYRYYwhSIKQTFG 345
gi 74687776  274 WPSe-------------hYGTMTLSLSQ-GSDT--TAATFTLDGVPAGTQAD-------VEKALNSFYiqGLKQ-MG 326
gi 48474991  278 WPTg-------------hYAEITFTFDQ-ADSY--TTLRMIMKGVPIGEEEV-------VQGNIQDYYirPIKTVFG 331
gi 268559430 284 YPNn-------------hHATIHFTLKD-NGSG--TDIKITAKEVPTHLADE-------TQTGLDRYYltSIARTFG 337
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