Conserved Protein Domain Family
T2SSG

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pfam08334: T2SSG 
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Type II secretion system (T2SS), protein G
The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet.
Statistics
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PSSM-Id: 311991
View PSSM: pfam08334
Aligned: 94 rows
Threshold Bit Score: 80.6747
Threshold Setting Gi: 81661389
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2KEP_A         1 MSRPDQAKVTVAKGDIKAIAAALDMYKLDNFAYPSTQQGLEALVKKPTGNpqpKN--WnKDGYL--KKLPVDPWGNPYQY 76
gi 122326613  62 LRQLGGARQSVARQAVQRIGSVLDLYRLDMGSYPSTSDGLGALVNRPAADa--DA--W-NGPYLkdRRLPQDPWNHPFLY 136
gi 122971679  33 FGKVDSAKVRTAETQVKMLKMAIQTYRLDVGTYPSS---LGDLHSAPNDVk--nY--W-DGPYLd-ETLPLDPWNKNYEY 103
gi 81622293   33 FNQADKAKAQTADTQVKMLKGALLTMRLDIGRLPTEEEGLALLNTPPSDErlgAF--W-HGPYLe-GGVPLDPWNRPYLY 108
gi 123128577  40 MGRLDKSKVRAAKLQIDTLAASLDLFKIDTGRYPTAQEGLTALIEQPAAL---EA--W-DGPYVrsGTSLTDPWEREFVY 113
gi 81661389   59 TGAQAEANANATTTQLNSLKSNIQMYQIRMNSLPE---TLEQLRDGPSDSakkAK--W-VAPII--TEIPLDAWGNALTY 130
gi 502031435  38 FSNVDKSKVKTAETQVKMLRGSLQTYRLDVGSYPTTAQGLAALMKAP-GDt--RN--W-QGPYLe-DEVPKDPWGNPYEY 110
gi 500110087  38 FGKADTAKVQTAETQIQMLKSGLLTYRLDVGSFPSEQEGLNGLNNPPSDEr--RRglW-DGPYLg-DDLPADPWGMPYQY 113
gi 500719147  39 MDSADQAKRDTVCLKMNDIGKRLDMFKLDNGVYPDTEEGLEALLSNPDAEk-yPN--YrAKPYL--RKLPKDSWETPFVY 113
gi 500034354  37 IEQLRGGQTEVAQNRMKILEEALLQYGRDVGDYPSQNEGLDALIESPRGA---PQ--W-QGPYTspPAL-LDPWNRSFYY 109
                         90       100       110
                 ....*....|....*....|....*....|....
2KEP_A        77 LAPGTK-G-PFDLYSLGADGKEGGSDNDADIGNW 108
gi 122326613 137 RSPSAReEmPYDLCSRGEKNVSGDVPAPGMICNE 170
gi 122971679 104 RVDSKA-AqGFYLYSLGADGVEGGEELNADIGYV 136
gi 81622293  109 SDRPSA-EqPFTLYSQGADGQPGGKGLDADVGya 141
gi 123128577 114 DAGSAS---SFKLVSYGADGKEGGSKHDSDII-W 143
gi 81661389  131 S----VnGnTFEIRSGGIDGQVNTDDD--IIVSG 158
gi 502031435 111 KAPVENlQ-GFALYSLGADGKPGGEGQDSDVGil 143
gi 500110087 114 KPSSSH-PqGFVLYSYGADGKQGGEGVDADIGYl 146
gi 500719147 114 IKKG---D-EFELVSFASDRKEGGEENNKDIRFS 143
gi 500034354 110 VYPG-HhG-VFDLYSLGRDNKKGGVLVNRDVQNW 141
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