3GN9


Conserved Protein Domain Family
T2SSG

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pfam08334: T2SSG 
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Type II secretion system (T2SS), protein G
The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. The T2SG family includes proteins such as EpsG (P45773) in Vibrio cholera, XcpT also called PddA (Q00514) in Pseudomonas aeruginosa or PulG (P15746)in Klebsiella pneumoniae. The PulG is thought to be anchored in the inner membrane with its C-terminus directed towards the periplasme. Together with other members of the Type II secretion machinery, it is thought to assemble into a pilus-like structure that may function as a dynamic mechanism to push secreted proteins out of the cell. The polypeptide is organized into a long N-terminal alpha-helix followed by a loop region that separates it from a C-terminal anti-parallel beta-sheet.
Statistics
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PSSM-Id: 337007
View PSSM: pfam08334
Aligned: 93 rows
Threshold Bit Score: 80.6785
Threshold Setting Gi: 81661389
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3GN9_A         3 MGNKEKADQQKAITDIVALENALDMYKLDNSVYPTTDQGLEALVTKPSSpEp--RN--YrNGGYI--KRLPKDPWGNEYQ 76
gi 123128577  40 MGRLDKSKVRAAKLQIDTLAASLDLFKIDTGRYPTAQEGLTALIEQPAA-L---EA--W-DGPYVrsGTSLTDPWEREFV 112
gi 81661389   59 TGAQAEANANATTTQLNSLKSNIQMYQIRMNSLPE---TLEQLRDGPSD-SakkAK--W-VAPII--TEIPLDAWGNALT 129
gi 75540615   23 MNMFSGAKSDTAALQVETITTALNYYRIDTGSYPDMEHGLRALWEAPPG-V---NR--W-RGPYVrkQQHLVDPWGRSYR 95
gi 122971679  33 FGKVDSAKVRTAETQVKMLKMAIQTYRLDVGTYPSS---LGDLHSAPND-Vk--nY--W-DGPYLd-ETLPLDPWNKNYE 102
gi 81622293   33 FNQADKAKAQTADTQVKMLKGALLTMRLDIGRLPTEEEGLALLNTPPSD-ErlgAF--W-HGPYLe-GGVPLDPWNRPYL 107
gi 502031435  38 FSNVDKSKVKTAETQVKMLRGSLQTYRLDVGSYPTTAQGLAALMKAPGDt----RN--W-QGPYLe-DEVPKDPWGNPYE 109
gi 500110087  38 FGKADTAKVQTAETQIQMLKSGLLTYRLDVGSFPSEQEGLNGLNNPPSD-Er--RRglW-DGPYLg-DDLPADPWGMPYQ 112
gi 500719147  39 MDSADQAKRDTVCLKMNDIGKRLDMFKLDNGVYPDTEEGLEALLSNPDA-Ek-yPN--YrAKPYL--RKLPKDSWETPFV 112
gi 500034354  37 IEQLRGGQTEVAQNRMKILEEALLQYGRDVGDYPSQNEGLDALIESPRG-A---PQ--W-QGPYTspPAL-LDPWNRSFY 108
                         90       100       110
                 ....*....|....*....|....*....|....
3GN9_A        77 YMSPGdk-gTIDIFTLGADGQEGGEGAAADIGNW 109
gi 123128577 113 YDAGSa--sSFKLVSYGADGKEGGSKHDSDII-W 143
gi 81661389  130 YSvn---gnTFEIRSGGIDGQVNTDDD--IIVSG 158
gi 75540615   96 YRLPGkh-gPVDVFSLGADDKEGGSGEDTDIGNW 128
gi 122971679 103 YRVDSkaaqGFYLYSLGADGVEGGEELNADIGYV 136
gi 81622293  108 YSDRPsaeqPFTLYSQGADGQPGGKGLDADVGya 141
gi 502031435 110 YKAPVenlqGFALYSLGADGKPGGEGQDSDVGil 143
gi 500110087 113 YKPSSshpqGFVLYSYGADGKQGGEGVDADIGYl 146
gi 500719147 113 YIKKGd---EFELVSFASDRKEGGEENNKDIRFS 143
gi 500034354 109 YVYPGhh-gVFDLYSLGRDNKKGGVLVNRDVQNW 141
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