3RYT,5E6P,4M8N


Conserved Protein Domain Family
Plexin_cytopl

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pfam08337: Plexin_cytopl 
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Plexin cytoplasmic RasGAP domain
This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.
Statistics
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PSSM-Id: 337008
View PSSM: pfam08337
Aligned: 59 rows
Threshold Bit Score: 357.635
Threshold Setting Gi: 780038707
Created: 28-Mar-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A         48 GIPFLDYRTYAMRVLF-----------P----Giedhpv-----lkemevQANVE--KSLTLFGQLLTKKHFLLTFIRTL 105
gi 166215089 1194 GPELINFPHFVENLLWsdnnltsap-------------------------slartlpvTLAQFHALLSFKGFIFTIVEAA 1248
gi 762148464  384 GIPYHSYQSYTQYILF-----------P----KeveaatiasllehsgfsSKNAE--KAMDQFDKLMSNKYFVKSLIGTL 446
gi 514701107 1444 eahpRPFGEYARRVYF-----------T----Aldthplpv--------rprfpgtnDCIEQFTFFLQQDDFLRAFVGVM 1500
gi 313234905 1393 TMPFREYRSFILHFMF-----------PpndeEnrhyhrelcpfgtqnsrSGTIDrsMGLQEFRKLLGQREFLLVFIKTL 1461
gi 341888335  956 qPEIVDFSRFMENLLW-----------A----Entltv---------pilarTLP--MALAQFHALLSFKEFIFTIVDVA 1009
gi 341877938 1342 tAPFLEYKDYCARVLF-----------P----NggknhpvlknlevdthkAEAIE--AGLREFHKLLMNKTFLLTMVRTM 1404
gi 780038707  897 GMPFVSGADYIRNMLFwglkvqpmtndP----El---------------pQESIK--QAMSEFSKLLNRKEFLMQYIQGL 955
gi 779995622  421 GVPFVNALDYSKNMLFaglavlppttdP----Ey---------------mNSDLE--TAMIMFSRQLSNPDFLTNFIKQL 479
gi 196006493 1233 SIPYLPFNGYAIKILF-----------P----Dneeyavhh-flnqregrRYDDD--DAVLLFADLLYKKKFLKIYLHTI 1294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        106 EAQ-RSFSMRDRGNVASLIMTAL--QGEMEYATGVLKQLLSDLIEKNLeSKnhPKLLLRRTESVAEKMLTNWFTFLLYKF 182
gi 166215089 1249 ESD-VSISTSEKSMLASLLISVL--LRNFSYCTEVVVDLLRAHIARSVqNKr-AELLFRNSDSVVEKMFSKWMSICLYSH 1324
gi 762148464  447 EKQ-RKITLSDKAQFAANFSVIM--MGKMRDFFEIVNCLLSTLVD-SAnKKq-HKTLFNRFESISLRLLSHWLSVSLYPY 521
gi 514701107 1501 EGEgRAFSVRDRCQVASLLMCSA--NGDEAMGTHTLSTLLDQYFTANSr-Rd-PRLMLRRTESVAEKLLTAWLTTGMHDA 1576
gi 313234905 1462 ESH-PKFTTRDRSKFAAFLMISL--QGKLEYATLILQYLIIDMIEKMPsHn--LGTLFRHSNTIGEKMLSYWFAMLMYRT 1536
gi 341888335 1010 ESR-NSISTSEKSMLASLLISVL--IRNFSYCTEIVISLLKTHIAKAVeNKr-AELLFRNSDSLVEMMISKWWCICLYPS 1085
gi 341877938 1405 EAN-KYFVGKDRVYVGSLLMVVL--QEKMGYCTEMLKQLLRELIEKTVeKKfqPKILFRRSESIAERMLAAWFTFLLHDH 1481
gi 780038707  956 DEA-KNLKQKDRVNIASLLSTILttEGRFHYLTDVMLTLMAEKIEESD-ENr-LKQLFKSVGSILEKLISNWVALCMYKH 1032
gi 779995622  480 EEQ-RKPKRRDRVNIASLITALLvtEGKFGYFTETLFKLLEESIEEGA-ESgrARSLFRRTETIVEKLLSNWISICMYQY 557
gi 196006493 1295 ENQ-QDFSMKDRCNVASLLMVAL--QHRMGYVTEILCHLLRELIHKSV-AKnhPKLILRRTECIAEKLLTNWLSFFFYPY 1370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        183 L-KECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQ-QIDYKTLTLNCVNPEh-eNAPEV--PVKGLNCDT 257
gi 166215089 1325 L--TPQMNSYFYLYKALQYQTDKGPVDAVTGDARYTINEAKLLRE-SVDTKTLKIRVIPFEk--CDESI--DLEVHACDA 1397
gi 762148464  522 L-KEGGGSSLFMLYKSTQTVVEKRPVDEVTGEAKNTLSEDNFLRE-KIDCLTMKLEIDLNGn-gN--LY--TCEVLDCDT 594
gi 514701107 1577 V-LRDAARPLYNLTQALKIYAWKGPVDAVTGAATYTLNADALLRE-RVEYEPLTLHVDM-----NRQVY--EVHVNSCDT 1647
gi 313234905 1537 V-YRRTGEHIFNLFKKLKDLVHSEPVDQITGHSRMTLSEQYLLRViNINTNQLSITVLHHEg-gEPQFI--QISGLYCDT 1612
gi 341888335 1086 L-K-PQMNSFYNLYKALQFQTDRGPVDAVTGDARYTINEANLLRE-CVETRTIIVNVIPLEn--CHDTV--RLELHSCDA 1158
gi 341877938 1482 LkTFDAGKKLYELFWGIKQQMEKGPQDAITLEARYSLSEEKLLRA-TFEYKELTVFVNSTDsvySSSQQdiPVRVLDCDT 1560
gi 780038707 1033 L-QKQVAYPLYVLYQAIKGQVDKGPVDAITGQAHFSLNFDYLLDE-DVEFEDVTLQIVD-----KEHKVleQVKVLDVDT 1105
gi 779995622  558 L-KRQVAESLYLLYQSIKMQVEKGPIDITTGQSVFSLNFECLLEE-EVEFNELTLSVVGRD---RHHKY--YVKVLDVDC 630
gi 196006493 1371 L-FGSIGDSLYVLYQAIKQQVDKGPVDEITADAKHSLSEDKLIRQ-NIDYQTLTLSAHF-----ERTTE--LVKVLDCDS 1441
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        258 VTQVKEKLLDAVYKGVPYSQRPKAGDMD-----LEW-RQGr---MA--RIILQDEDVTTKID-ND--WKRLNTLAHYQ-- 321
gi 166215089 1398 ICQVKQKVASAVYRETPYSQRPRITQFE-----LKY-KCPk---RG--DVKLTDVLPIETLS-QKklPVKLFTLADYG-- 1463
gi 762148464  595 INQVKSKCLYQIYKNKPASEMPSTDEVD-----LEW-MAGk---SG--RLTLSNIDQTSERG-DG--MVRRNTLKHYH-- 658
gi 514701107 1648 IGQILEKL-----KLVVTTAGADVSDFDtrvlvLQR-EEGl--------RVLKDIDDSSKMS-AG--WVQLNTASFYG-- 1708
gi 313234905 1613 VDQIKERILDTIYWDVEYSKRDSVADYD-----LEY-VDNslkvPL--RRLMKNVDSSSEIK-DG--LRRLNTVEHYQkl 1681
gi 341888335 1159 IRQVKQKVAAAVYYKTPYSQRPRITQFD-----LRF-KCPr---QG--EIRLVEFRTLSKKK-L---PVKLLTISDYD-- 1221
gi 341877938 1561 ITQVKEKCLDSKYRGYRFADRPAANEME-----LEW-KTGl---NG--KMTLQDIDSSSRIEgGN--WKRLNTLAHYN-- 1625
gi 780038707 1106 ITQAKQKILDAVYCKRQTAQQLRSNEVD-----LVL-LNGc---MG--RLVLKDRDPITETR-GH--WIKANTIKAYK-- 1169
gi 779995622  631 MTQVKQKILDAAYRNSHIVQQNRAHEMD-----LLWyHPGg---E---ERILKDRDELNKTV-GNtkDLFINTVKTYG-- 696
gi 196006493 1442 ITQTKEKILDAIYKSAAYSRRTPAEEID-----LEWiRDTp---SGlvRIILKNEDDSSNIS-GR--WKRINTLKHYQ-- 1508
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        322 -VTDGSSV----ALVPK-------------QtsaynisnsstftkslsryesmlrtaSspdslrs----rtpmitPDLES 379
gi 166215089 1464 -ISDGCTLemspAVYTAesyrnsladsgqssw-------------------------------------ssldrcspiys 1505
gi 762148464  659 -VLDNSRM----ALLYK--------------------------------------------------------------- 670
gi 514701107 1709 -MRDGDQL----AFVKSdtdggdarrrrnnnssssgggggg-------------------ggggslfkvrtksksridpm 1764
gi 313234905 1682 fLPNAKKL----DFTDK--------------------------------------------------------------- 1694
gi 341888335 1222 -VQDGSIL----EMTPAfyalenhsqsiadsetl---------------------------------sctsvdinspays 1263
gi 341877938 1626 -VPNNAIL----TLSSKsnslynlsilsdrsekssltmks------------atvgspkpwgappsviadhasssNDTDN 1688
gi 780038707 1170 -VSyqqqyiyfkidsqkfn------------------------------------------------------------- 1187
gi 779995622  697 -VSDGCQV----ALIVKasmnetgtyqpvtpgvqlfqqyqe------------------hagpddvrdrdyirirtmesg 753
gi 196006493 1509 -IPDGASV----VVIPRtsasslsvssnssT--------------------------RypvssrsllgrlsvdenGETHY 1557
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        380 GTKL-----------------------------------------------WHLVK----NHD-HLDq------------ 395
gi 166215089 1506 sskY-----------------------------------------------YHLTN----PSSgTMTf------------ 1522
gi 762148464  671 ---FspdvehddeddtyvnqrspsdvditippnvqliqsvsstgslenlrqWHLVK----NIE-EEDs------------ 730
gi 514701107 1765 aceP-----------------------------------------------WHLVK----PDT-DGTa------------ 1780
gi 313234905 1695 ---R-----------------------------------------------YLELK----PST-STTmlgqshqsgssls 1719
gi 341888335 1264 fleH-----------------------------------------------YHLVK----STSgSLMc------------ 1280
gi 341877938 1689 GYKL-----------------------------------------------YHLVK----PTE-HGPt------------ 1704
gi 780038707      --------------------------------------------------------------------------------
gi 779995622  754 gsrI-----------------------------------------------MHLVAenqmPTE-SSTs------------ 773
gi 196006493 1558 N--L-----------------------------------------------WHLIK----PMD-ENSt------------ 1571
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        396 ------R-EGDR----GS-------------------------------------KMVSEIYLTRLLATKGTLQKFVDDL 427
gi 166215089 1523 -----kK-KSSNdsnlLP-------------------------------------KSIPEVYLTRLLTSKGTVETYVEDF 1559
gi 762148464  731 ------HeKPSK----LK-------------------------------------DIGKTSHITNLMHTKLVLQDNIKEV 763
gi 514701107 1781 ------AaAAAA----AT-------------------------------------RVPSEIFLTYLMTVKTALQPFVDDL 1813
gi 313234905 1720 rsrinvSeHPSS----SNmtgtmgrsgtplhgeivrdgrqiidyhhvydgissrkMAAPDHFTLTMIRAKESLETPIQVL 1795
gi 341888335 1281 ------RpKSSTd---VP-------------------------------------KSIPEVYLTRLLTSKGTVEAYIEDF 1314
gi 341877938 1705 ----------DS----QE-------------------------------------KMVTEIYLTRLLMMKGTLAKFITSL 1733
gi 780038707      --------------------------------------------------------------------------------
gi 779995622  774 ----------------LT-------------------------------------KLDREFLAPRLLVTKKTIQTRLDEF 800
gi 196006493 1572 ---------DPN----AN-------------------------------------KLVSEVFLTRLLSTKHILQTFVDDL 1601
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        428 FETIFSTa--HrgSALPLAIKYMFDFLDEQADKHQIHDS-DVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLS 504
gi 166215089 1560 LESVLYMh--D--SSYPPILKFFFDILDREASVNGVSE--NICQQWKANGYVLRVWANFVRNPQLVFDVPHSISMDANLS 1633
gi 762148464  764 FDSVLN----H--ETVPLVVHYLFGVLENLANKNSV-EP-DTLLCWKSESYAMRVWATLLVRPEFLFDIQKARHVEPCLN 835
gi 514701107 1814 VDAVFNI------DQPSPAVRFLFHFLDDQARKHNISDP-RTTHIWKSNAFPLRFWINLIKNPDFLLHVQQTRTVSSGLS 1886
gi 313234905 1796 IESIVSVvdrQ--YQMPMCIKYMFDFLDDEFQKVEQRHP-DTIHKWKTNSLFLRYWVNLIKNPEFLFDINKSPAVSNSLT 1872
gi 341888335 1315 FESVLYMh--A--YKFPPILKYVFDTLDHEAEINEVED--NISHQWKANGFVLRVWANFIKNPQLALDLPHSISMDANLS 1388
gi 341877938 1734 LESIFSA------RNVPPCIKYMFDFMDEQAREHGINDP-EVVHAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCLS 1806
gi 780038707      --------------------------------------------------------------------------------
gi 779995622  801 LACVFKK---P--AETPLTIKYLFDFFDKMANKYCDEKSeEIAEAWKSNSLPLHYWMTTLTHPSYVFDMRQSRSADQSVS 875
gi 196006493 1602 FSQMFTVpqtL--YHFPKVIKYLFDFLDYEAFKLGFTTEnDVAHTWKNNCLPLRFYINIVKNPHHAFDVNKSGTVDSCLS 1679
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3RYT_A        505 VVAQTFMDSCSTSEHK--LGKDSPSNKLLYAKDI-PNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQ--FNSM 579
gi 166215089 1634 TVAQTMMDCFSFSEPV--LGAHSPSSRLLFAKDV-ARLRPLSVDLFKRVKNSPPLGMDELRTELVNMANDVSTC--KGSS 1708
gi 762148464  836 VIKQVFIDCFHST--K--ISKDSSLQKLLFAQEV-PHYQKKTEQFYKALGNKAAITDADFWSEMSRLSLLQQEHlkFSKS 910
gi 514701107 1887 TVAQVIMDSCSVSDQQ--LGKHSPANKHLYRKEV-AEYKQKIANFYTAISRLPPPTDAELQASFASAQSGEQAC---DRP 1960
gi 313234905 1873 VVAQTLIDGCSTTESDplLAQAQSTSKVLFSKSVhNNFREWVQSYFEEVRMREEIPRDDFILFLREENELHMHD--FNKN 1950
gi 341888335 1389 IIAQTMIDCFSFSEPV--LSAQSPSSRLLFAKDV-ARLRPFSADLLKRIKNFPSLSINELEIELdlstykgsslalsell 1465
gi 341877938 1807 VVAQTLMDACSTQDHQ--LTKDSPSSKLLFAKDM-YQYRDLVDSYYTEISMTPRIDDGTMAANLSAESRQHNGE--FHVF 1881
gi 780038707      --------------------------------------------------------------------------------
gi 779995622  876 VLANMLDNACKKIRSE--NTQESALNRVLFYRDL-PGHIRTIGEYYENIKGLPPPTTEELQEDFNRITQDFSGL--FSRV 950
gi 196006493 1680 VIAQAFMDSCSITDNR--LGKDSPSNKLLYARET-SDYKARVQKFYADIQYMPPVSLDELLHTHEDMMRRFRVKrnFNSL 1756
                         730
                  ....*....|....*..
3RYT_A        580 SALHEIYSYIAKYKDEI 596
gi 166215089 1709 LALSELLSWVRGNGIRI 1725
gi 762148464  911 AALVKLYRFVNQYVEEI 927
gi 514701107 1961 DAVCGLMEYALRFREQL 1977
gi 313234905 1951 FAIRELFNYAKEYYNDL 1967
gi 341888335 1466 swvrgnairitehlssc 1482
gi 341877938 1882 SALNELYKYLDQYKESI 1898
gi 780038707      -----------------
gi 779995622  951 ATLNKLYDFTShdtgpl 967
gi 196006493 1757 NAVHELFTYATKYITEl 1773
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