Conserved Protein Domain Family
FAST_2

?
pfam08368: FAST_2 
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Statistics
?
PSSM-Id: 312018
View PSSM: pfam08368
Aligned: 84 rows
Threshold Bit Score: 68.3554
Threshold Setting Gi: 597734413
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123892534  648 LMELNRAVCLECPEFQIPWFHDRYCQQLQHRANGGI---SSVQRQIHQLLGEILGGI-N-YAKVSVMTPYYHAIDFECIL 722
gi 348560068  454 LMNINATAQLEHPEYQGPFLPATA---VGPTPSSPDqkvTLLQQELRETLQELLGNA-S-QGSFNVVTQYGWVLDAEVLL 528
gi 1043417833 100 LAHINATALLEHPEYTGPHLPNESISTTHAVTANRk--lSPLQSGLQEVLRELFPVE-G-TCRCGVNTVYGWYIDGEVVL 175
gi 334342438  449 LVHINATAQLEHPKYIGPYLPLATCQQAFRLQTSTSrkmTPMQKDLQDIMKGWLGSE-D-KVRFGETTQYGWELDAELVL 526
gi 733891549  458 LIQINAAAKLESPEYQGPFLPA----GMLSAAEPAAekvTLLQSSLREALAGVLGSQ-D-NGRWDVHTIYGWQIDAEVVL 531
gi 351706210  453 LLHVNATAQLEHPEYRGPLLPATAVA-----PTSPGrkvTPLQQELREALQAVLGSA-D-QGSLEVATQYGWVLDAEVLL 525
gi 874489853  364 LLHINATARLEIPEYQGPFLTPNL----LGTVGSAGeggSQLQGSLREALTGVLGDQ-D-RARFDAPTIYGWQIDAEVVV 437
gi 348526914  460 LLHIAATLSLEHPG----SLDTLPSQSVLSVPASSSp-lSPLQRTLRETLLKFVGGK-SeALRTGVDTVYGWSIDGELIV 533
gi 765145230  458 LLHIAASLHLENP---GSSAGPVSSPSILPVPANASp-lSVLQRSLRETLQSLVGGKtE-VLRVGVNTVYGWTIEGEMVV 532
gi 984108793  455 LLHINATALLEHPDYKGPLLPASALASK---PSAPDkkmTPLQKELQETLKVLLGSS-E-RGCLEVATRYGWVLDAEVLL 529

                  ....*..
gi 123892534  723 DKNKKPI 729
gi 348560068  529 DTDGQFL 535
gi 1043417833 176 DSDNKPL 182
gi 334342438  527 DVENQPL 533
gi 733891549  532 NSENKPL 538
gi 351706210  526 DADGQFL 532
gi 874489853  438 NAENKPL 444
gi 348526914  534 DADNKPV 540
gi 765145230  533 DCENKPV 539
gi 984108793  530 DADGQFL 536
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap