Conserved Protein Domain Family
Protocadherin

?
pfam08374: Protocadherin 
Protocadherin
The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.
Statistics
?
PSSM-Id: 312022
View PSSM: pfam08374
Aligned: 17 rows
Threshold Bit Score: 240.802
Threshold Setting Gi: 821494259
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216100   969 SLANASLVEAQIARSLAA-PLSLDIAGDPDSDrsLGKQRLSVAIGVLAGAAAVILVILLVVTARQCGAQ-GKNGYEAGK- 1045
gi 47219383   772 TISNVSLVEALVGHSLYT-PLDRDIAGDPDNG--FAAHRSNILFGSLAGVAGVVLLILVVVFIRHRIQReTKSGYQAGK- 847
gi 972977665  581 TINNVTLVESLVGHSLYT-PLDTDIAGDPDYR--HAAQRSNILYGSLAGIAGVILVIVIVVVIRYHLQKeAKSGYQAGK- 656
gi 528500433  787 TIGNVSHVEGLVGHSLYT-PLEMDIAGDPDYS---RDPHSNILFAVLGGFSVVILIIVVAMIIRHLVLKeNKSGYQAGK- 861
gi 195325650  317 TAGNASYIYDLIRRTMET-PLDRNI-GDSSQPy-QNEDYLTIMIAIVAGAMVVIVVIFVTVLVR-CRHA---SRFKAAQr 389
gi 410913649  782 TVSNATFIQEQLRKSMET-PLDRNI-GDSEVTa-QANGYVIVVIAIIAGTMTVILVIFVTALVR-CRQT---PRHKVVQk 854
gi 612059120  792 SLHNSSFVDELLRRARGK-TRNREV-EKTDVAntINSDYIKYIIAIISGSMTAVLTIVIAAILR-CRHF---PGFK-AR- 863
gi 821494259  775 TLYNSTFVDELLRRNRGRfSVTHRV-QKTDVAspSSSDYIKYIIAIISGSMTAVLTIVIAALLR-CRRF---PRFRGAR- 848
gi 351710657  742 SVSNVTQIHELVHKSIET-PVTQNI-ETADASl-TTSDYVKIMVAIIAGTITVILIIFLTAVVR-CRQS---PQLKSAQk 814
gi 859964681  612 SVTNATWIHELVH-NIET-PVTPNI-ETTDASs-PTSDYVKIMVAIIAGTITVILVIFITAVVR-CHQS---PHLKASQk 683
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216100  1046 -KEpEEDFFSPSgaqpqvsRgrgSDRG-----RKPRRDKRTGSsggvs-agggkSDRSLYSGIVTVNGLRRhanDDEEEe 1118
gi 47219383   848 -KE-TKDLYAPK-------QapkNAKG-----KRGRKGKPQKPpkplgedeevsLQKSLKFNL-----------DGVS-- 900
gi 972977665  657 -KE-TKDLYAPK-------QgpkSSKG-----KKGKKGKAPKPakpieedeeasLQKTLKFNLIN---------DGVT-- 711
gi 528500433  862 -KE-TKDLYAPK-------PgpkSNKN-----KKAKKSKAPKPanpseedeggtLQKGLKFNLMN---------ENVN-- 916
gi 195325650  390 sKQ-GAEWMSPN-------QenkQn-------KKKKRKKRKS-------------PKSSLLNFVTIEESKP---DDAVH- 437
gi 410913649  855 gKQ-SGEWVSPN-------QenrQIk------KKKKKRKKRS-------------PKSLLLNFVTIDESKP---DDPTH- 903
gi 612059120  864 -KQ-NSEWVTPN-------PansETITl-------TTTDIGG-------------ANSVIVNLVSLSEPRT---DDAENe 911
gi 821494259  849 -KQ-NSEWVTPN-------PansEAITi-------STNDNRG-------------PNNVILNLVSFAESGN---EELENe 896
gi 351710657  815 nKQ-NSEWVTPN-------PenrQMRVm---kKKKRKMKTHA-------------PQNLLLNFVTIEKTKT---DDANN- 866
gi 859964681  684 nKQ-NSEWVTPN-------PenrQMVMmmmkkKKKKKKKKHApknlllnfvtie------------------eikaddvd 737
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47216100  1119 lSSASDRLAAr---------------YCVVDDDPgsprmgsgrrhqSSPDLARHYKSSSPLPAVNLQPHSPPAegKKHQA 1183
gi 47219383   901 ---DSPRI------------------HLPLTYSP------------GSPDIGRHYRSNSPLPSIQLQAQSPSAs-QKHQV 946
gi 972977665  712 ---DSPRI------------------HLPLNYPP------------GSPDLGRHYRSNSPLPSIQLQPQSPSAs-KKHQA 757
gi 528500433  917 ---DSPRI------------------HLPLNYPP------------GSPDLGRHYRSNSPLPSIQLQPQSPSAs-KKHQA 962
gi 195325650  438 -EPINGTISLpaeleeqsigrfdwgpAPPTTFKP------------NSPDLAKHYKSASPQPAFHLKPDTPVSv-KKHHV 503
gi 410913649  904 -EHVNGTLDLpveleeqt-mgkynwaTTPTTFKP------------DSPDLAKHYKSASPQPTFQIKPETPVAp-KKHHV 968
gi 612059120  912 -EEVTTSIDVavdieeat-mekynwgTNSSTFKP------------DGPDLAQHYKATSPQPAFHIEPETPVH--SKHHV 975
gi 821494259  897 eEEVSTSLDVvidieedt-makynwgTHSSTFKP------------DGPDLAQHYKATSPQPTFHIEPETPMH--SKHHG 961
gi 351710657  867 -GGNGVTLDLpieleekh-mgkynwgTTPTTFKP------------DSPDLAQHYKSASPQPAFQIQPETPLN--SKHHI 930
gi 859964681  738 ndgnSVTLGLpieleeqt-mgknnwgTIPTTFKP------------DSPDLARHYKSASPQPAFQIYAETPLN--SKHHV 802
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 47216100  1184 VQDLPPSNTFVgsggcvgsagssssssggsGNG-DAMSVGSDQCSE-YGCHTGN 1235
gi 47219383   947 VQDLPAANTFV-------------------GTGgDDNSTGSDQYSD-YSYKTSQ 980
gi 972977665  758 VQDLPATNTFV-------------------GTG-DNNSTGSDQYSD-YSYKANP 790
gi 528500433  963 VQDLPATNTFV-------------------GTG-DNNSTGSDQYSD-YSYKANS 995
gi 195325650  504 IQELPLDNTFV-------------------GGC-DTLSKRSSTSSDhFSASECS 537
gi 410913649  969 IQELPLDNTFV-------------------VGC-DSLSKCSSTSSDpYSVSECG 1002
gi 612059120  976 IQELPLDNTFV-------------------MGC-DSLSKCSSSSSDpYSISDCS 1009
gi 821494259  962 IQVLPVDNTFV-------------------LGC-DSLSKCSSSGSDpYSISDCS 995
gi 351710657  931 IQELPLDNTFM--------------------AC-DSISKCSSSSSDpYSVSECS 963
gi 859964681  803 IQELPLDNTFV--------------------TC-NSISKCSSSSSEpYSVSECS 835
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap