Conserved Protein Domain Family
NERD

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pfam08378: NERD 
Nuclease-related domain
The nuclease-related domain (NERD) is found in a range of bacterial as well as archaeal and plant proteins. It has distant similarity to endonucleases (hence its name) and its predicted secondary structure is helix - sheet - sheet - sheet - sheet - weak sheet/long loop - helix - sheet - sheet. The majority of NERD-containing proteins are single-domain, but in several cases proteins containing NERD have additional domains which in 75% of cases are involved in DNA processing.
Statistics
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PSSM-Id: 312026
View PSSM: pfam08378
Aligned: 359 rows
Threshold Bit Score: 30.1336
Threshold Setting Gi: 0
Created: 26-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122313095    23 DNNKGQ---RQLWN-ALKna--fEQD-EGVAYYRYPIfa------tsKRgrsEPDFLMIHRRfgIWI-FESKG------- 81
91_pfamImport    1 KGHMGE---FRLYR-KLKr----lVK-EDEIYTNIYLpg-------lNTthtELDLLVVSKKg-LIV-YEVKNyg----g 58
230_pfamImport   1 RGEWSE---RRVVLkLLKa----GIN-PKAIFHDLYIqk-------pNGtytQVDVAVATKVg-LIV-FEVKDys----g 59
63_pfamImport    1 KGKYGE---YLSFN-ILEk----IKG-EHRILTNVYLpk-------eNGettEIDLIYLHETg-IYV-LESKNys----g 58
174_pfamImport   1 KGMYGE---YLTFR-ELE-----KIKgNHRIITNVYLpcd----ngkTT---EIDLIYIHESg-IYV-IESKNys----g 58
110_pfamImport   1 KGIWGE---YLTTR-QLE-----KVGgYGKFVMNTYLpkar---gkgLT---EIDVTFIHESg-IYV-LESKNys----g 59
73_pfamImport    1 FGAEYE---KKIVE-KLRnyfekRDE-KFLIFENIYFetgeyneklkVYrtiQIDILIVTQK--LIIpIEVKHlsdeyck 73
182_pfamImport   1 IGFRFEakiRNKLL-TIA-----KDK-NYKYLNGGLFky-------gQSqifELDGILISNKa-VFI-IEVKYyv----g 60
255_pfamImport   1 KGKIFEetiKEKLS-YIA-----EQK-NYKFLDGGLFky-------aENnyfELDGILITSKa-VYI-IEAKRyi----g 60
gi 81614140     67 IGEVAE---KRINS-SLKa---wSKQ-SKSIFINSSLyk------ydDNklfEIDSILITNRa-IIV-VEIKSmt----g 126
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 122313095    82 CTIGNiaaieghdwq-mrdwyadsmSPISQIEAQLFEVRALFkpspmlEKLKIPFEYRVVLP 142
91_pfamImport   59 YIYGSkldtywtqvl-nyfskhkfyNPLRQNYAHHKALENYL------TIPFESVYPVVSFS 113
230_pfamImport  60 WIFGNehqkywtqllaygkekhrfyNPVMQNAGHIQAIRQCLp-----QNPGIPIYSVIVFF 116
63_pfamImport   59 WIFGDekskywmqtl-kngqkekfyNPIKQNNTHIKYLIKLL------KVDEKLVKSIIVFS 113
174_pfamImport  59 WIFGNendrywtqvf-knkrkekfyNPIKQNATHIKSL-INVc-----tIENEFVRSIIVFS 113
110_pfamImport  60 WIFGKeadqqwtqmf-knrykqkfyNPIKQNEQHLKSM-ERFle---aMVVEDVFQSVIVFG 116
73_pfamImport   74 RITGGadsrtwnli--knlgrsrmtNGVRQNRMHTQFTSELVe----fLGFNIPICGMTIIG 129
182_pfamImport  61 HLSGEatnaelelrs-ksnkvlkfkNPLIQNFKHIQHFYKMC-------GFNFPVFSLVILP 114
255_pfamImport  61 YLHGGffddylllr--derkeikvkNPFNQNYRHIRHFINMC-------KINVPIFSLIIFP 113
gi 81614140    127 IIKGDgevkdwkkv--lgnqvftfyNPILQNNRHIEHIIRII-------KKKIPIISLVIFS 179
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