Conserved Protein Domain Family
Augurin

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pfam15187: Augurin 
Oesophageal cancer-related gene 4
Augurin is alternatively named oesophageal cancer-related gene 4 protein. The function of this family of transmembrane proteins, is to induce the senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation. Augurin has been found to stimulate the release of ACTH via the release of hypothalamic CRF. This family of proteins is found in eukaryotes. Proteins in this family are typically 145 amino acids in length.
Statistics
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PSSM-Id: 317585
View PSSM: pfam15187
Aligned: 10 rows
Threshold Bit Score: 172.3
Threshold Setting Gi: 556984205
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239977072  29 SKLHRILIKRDakeIEsRP-KAYISVQQSKAKEFLSGLHRTKRNVWDRSRPDVQQWIQQFMYMGYDEARLETDLSYWMDQ 107
gi 82179011   19 NKLRLMLQKRE---AG-EPsKTIVSVKENKANEFLNSLKRPKRQLWDRTRPEVQQWYQQFLYMGFDEQKYEDDLSYWMSQ 94
gi 542240982  28 gHLHKILRKRDvagTGtAPsRSSVAVPSSRAKEFLAKLSRTKRNLWDRSRPDVQQWIMQFMYMGFDEQRLEADMAYWRDH 107
gi 941776306  43 NRLQKILVKRNvaeAEhAPsKSSVAIPSSKAQEFLAKLSRTKRNVWDRSRPDVQQWIMQFMQMGFDEQRLEADLQYWMDH 122
gi 524979014  36 NKLKLMLQKRE---AS-AAaEPEVSVKERAAKEFLSSLRRQRRQLWDRSQPDVQQWYQQFLYLGFDEQKFEDDISYWTNL 111
gi 395843150  32 NKLKLMLQKRE---AP-APaKAKVAVHESKAKEFLTSLKRQKRQLWDRSRPEVQQWYQQFLYMGFDEAKFEDDVTYWLNR 107
gi 973192745  30 NKLQKLFKKRE---AKpEP----LAVSPSKAKEFLTPLKRPKRNLWDRSRPDVQQWIQQFMYMGFDESRFETDLSYWMDH 102
gi 62955363   29 SKLEKLLMKRVdrdVK--P-AAAVAVSPSKAKEFLTSLKRPKRNLWDRSRPDVQQWIQQFMYMGFDEARLETDLAYWMDQ 105
gi 556984205  29 NKLRLMLQKREe--------KPAIAVSETKANGFLNKLKRYKRQLWDRSQPDVQQWYQQFLYMGFDEAKFEDDVSYWMAR 100
gi 47226914   27 sslqrILKTRD---AGdPPaRASVAVPPARAQEFLAPLSRTRRNIWDRSRPDVQQWIQQFMYLGFDEQQLEADLSYWMDH 103
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 239977072 108 ARS-ND-QG--RQHHHDENAPMSQQDPRYNRHGANVNYDYY 144
gi 82179011   95 GRGgSEyYGgfHQHHYDEDAPIGPRNPYTFRHGAGVNYDDY 135
gi 542240982 108 MRA-ND-PG--RQHHYDENAPIAPQDPSSYRHGANVNYDYY 144
gi 941776306 123 ARS-HD-QG--RQHHYDENAPIGPR--SSYRHGANVNYDYY 157
gi 524979014 112 GRArNEyYGgyYQHHYDEDSPIGPRNPHSFRHGAGVNYDDY 152
gi 395843150 108 DRNgHEyYGdyYQRHYDEDAAIGPRSPYSFRHGASVNYDDY 148
gi 973192745 103 YRQ-HDyYG--YQHHYDENAPIGPRYPSSFRHGANVNYDDY 140
gi 62955363  106 HRS-SD-QG--RQHHYDENAALGPRGAASYRHGANVNYDYY 142
gi 556984205 101 RNGgHEyYGgyYQHHYDEDAPIGPRYPHTFRHGANVNYDDY 141
gi 47226914  104 ARA-HD-QG--RQHHYDENGPLGPR-APQFlqtrsrrqlrl 139
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