Conserved Protein Domain Family
FAM181

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pfam15238: FAM181 
FAM181
This family of proteins is found in eukaryotes. Proteins in this family are typically between 256 and 426 amino acids in length.
Statistics
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PSSM-Id: 317621
View PSSM: pfam15238
Aligned: 7 rows
Threshold Bit Score: 249.908
Threshold Setting Gi: 260818527
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637242628   6 ADSEVKTLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYARLPRChhhhHPHHMQQ----------PsS 75
gi 557019814   3 SDSEVKTLLNFVNLASCDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRIPRC----HPSRLAE----------T-S 67
gi 260806799  51 sEVETDSLLSFMDTACNSIKLALDRPSRSRRKVNHRKYLQKQIKRCTQKLS----------PGDGES------------- 107
gi 260818527  80 ADADVKTLLNFVNLASSDIKAALDKSAPCKRSVDHRKYLQKQLKRFSQRRV-LPRY----VATRPVKditatttppaAsL 154
gi 537165592  66 ADSDVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRLPRG----LPGRVTE----------P-H 130
gi 928142823  69 SDSDVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRLPRG----LPGRGAE----------P-H 133
gi 966956450   3 SDSDVKMLLNFVNLASSDIKAALDKSAPCRRSVDHRKYLQKQLKRFSQKYSRLPRG----LPGRAAE----------P-Y 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637242628  76 LRERKAELeg-------------kSRGLnTS---ESPEASEGRVAVVATTSASILaQSDKACKADHERQQ---QqgtSEA 136
gi 557019814  68 LKNTVEDK----------------SRGF-IL---DRSELNNFKTLHENVSRASEL-DCEGASKSDHILSD---Q---GKE 120
gi 260806799 108 -----DDKdd------------------nAS---DKEAATANKPTSRRDSHIGAQsKSLAALFDPNTLKRpvnP---APT 158
gi 260818527 155 LKRRPESTssvn---------sesSSG--SG---SESCGSEAGPILAESCHPIDLsMPDRELPGEKEQEA---G---LQD 214
gi 537165592 131 LQRGPEERpgqlplhpcpesnpggGGGY-K----EKALGTPFR---------------EECLSKEQSFQG---L---NPE 184
gi 928142823 134 LKRGAEDRpgrlplgsghdsstgeGGGC-K----EKALGNPYR---------------EECLSKEQTLQR---Q---NPE 187
gi 966956450  68 LKRGSEDRpgrlll----dlgpdsSPGG-GGgckEKALRNPYR---------------EECLAKEQLPQG---Q---HPE 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637242628 137 LARPDQVPMRKRQLPASFWEEPRPTQgplSLFASSPLSSS-----------KDLLP-----------------LYEGKKS 188
gi 557019814 121 VGRQDHVPMRKRQLPASFWEEPRPTK---TLLTPSHLHVE-----------QQSVPpvnesvsdvksesrsrtCAESAQD 186
gi 260806799 159 RGRT-RVPLRKRNLPPSFFTEPGNQSgprGAFQTCTVAGSwpldgyrhpgvSDSLDifnpdiadlitnwqdesGHISDPS 237
gi 260818527 215 PAGADSVPLRKRALPASFWQEPGVQKgq-------------------------------------------ssSSRGSPS 251
gi 537165592 185 AARPGQVPMRKRQLPASFWEEPRPTL-------SYPMGLE-----------VGLAPre-------------asLYENKKN 233
gi 928142823 188 AARPGQVPMRKRQLPASFWEEPRPTH-------SYPLGLE-----------GGLGPre-------------gpPYESKKH 236
gi 966956450 122 AAQPGQVPMRKRQLPASFWEEPRPTH-------SYHVGLE-----------GGLGPre-------------gpPYEGKKN 170
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637242628 189 LKGPdgfa--slknLVPLYegkkSHKGPDRFisskdlpplyegkkrqkgsdggtserPDAEALQVLSTWGCWPFQCHGPQ 266
gi 557019814 187 TLGL----------PVQLC----REKEPVKF--------------------------QMTSISSRMSLCGCCSFQYHGQH 226
gi 260806799 238 MS---------------------AHAMPGNT--------------------------AMAAPGDHASIMLHMPSQPYGTN 270
gi 260818527 252 CSAEe-----------------sSAGSPGK---------------------------QDCQPAGETTAXPPRDITSHGLD 287
gi 537165592 234 CKGLeslgpetapaPLPMSprvlADMEPLKM--------------------------SGVSLVGSLDAWSYCPFQYHGQP 287
gi 928142823 237 CKGLepld--petaPVPTSprapAEKEPLKM--------------------------SGVSLVGRVNAWSCCPFQYHGQP 288
gi 966956450 171 CKGLeplg--peivPVPMSpralAEKEPLKM--------------------------PGVSLVGRVNAWSCCPFQYHGQP 222
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637242628 267 ----------------TSPGlyvpplplaaALPSPA-APFPALG-----LWRKNGGSSMEGEAFGK-LGGmGQKVYhRPV 323
gi 557019814 227 ----------------VFQT----------HIALPQ-SGFPDVD-----LWRKNGVSNIEVQNICKdSIN-GQNVH-RPV 272
gi 260806799 271 fnmnypqtqsnqglltTAPQswms--gspsYPSAPA-SNYPASR-----DDFSRVGYPS------SsSAGlSGSLY-APQ 335
gi 260818527 288 ----------------RFPTagaa--rtarVTAVPRvPPVPRVRppsslRVRPRSAAGSAAGTLRSpWPGaGARTV-RPP 348
gi 537165592 288 ----------------IFPSl---------PGVLPQ-GPVPSLG-----LWRKSPASPVELAHFCKdVDSsGPKVY-RPV 335
gi 928142823 289 ----------------VYAGp---------PGALPQ-SPVPGLG-----LWRKSPASPGELAHFCKhVDGpGQKVY-RPV 336
gi 966956450 223 ----------------IYPGp---------LGALPQ-SPVPSLG-----LWKKSPAFPGELAHLCKdADSlGQKVC-RPV 270
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 637242628 324 VWKPI-----------------------------------------------PTKPA 333
gi 557019814 273 VLKPI-----------------------------------------------PTKPA 282
gi 260806799 336 VHQM------------------------------------------------PSGLP 344
gi 260818527 349 PTKGVvlvlpgaehfrlggvqsvpvrtppprvrartpqsagggtrailpsmgPDKPS 405
gi 537165592 336 VLKPI-----------------------------------------------PTKPA 345
gi 928142823 337 VLKPI-----------------------------------------------PTKPA 346
gi 966956450 271 VLKPI-----------------------------------------------PTKPA 280
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