Conserved Protein Domain Family
FAM53

?
pfam15242: FAM53 
Family of FAM53
The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.
Statistics
?
PSSM-Id: 317624
View PSSM: pfam15242
Aligned: 22 rows
Threshold Bit Score: 191.514
Threshold Setting Gi: 432878675
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181181    1 MVTLITEKLQNQ-SLDDLSCKTYNLNLHPSVKLNKSACLFPYEINEDSPWKVLNGTYPIRNEVnknsifsfstcpysAGT 79
gi 573885141   5 MVIIHPKTLEKKkGVDDVTCKASDSELQKPQKMSKGTALYACGVVESDGWRDLGRGCAFQKDP--------------GGA 70
gi 499020931   5 MVIIYPKTLEKK-GADDVTTKRTNFVPFQAQTMSQGTALFSCGLMDTSRWRDMGHRCAIQRRP--------------VGT 69
gi 348535524   1 MVTLITEQLRKQ-SLEEPYHKAFSFSV--------NVSLPTVGSSPTVSWSA-HKTTQes---------------ytSTT 55
gi 551487921   1 MVTLITEQLCKQ-SLEEPYHKAFTFNA--------SVSLPAVGSSPTISWNSgKTTQEAS-----------------SDT 54
gi 432878675   2 MVTLITEQLRKQ-SLEEPYHKAFSFNSt--------vSLPAVGSSPTISWSE-SSTIQAHpss----------------- 54
gi 768937668   1 ----------------------------------------------------------------------------pDSS 4
gi 941757349   5 MVIIYKKTVEKK-GGDDVTTKRTDLGTaqt--msqGAALFSCGLMETSRWREvGTSCALQQRP--------------VGT 67
gi 348508570   5 MVIIYPKTLEKK-GADDVTTKRTNFVPfqaqtmsqGTALFSCGLMDTSRWRDmGHRCAIQRRP--------------VGT 69
gi 591306132   1 MVMILSKSLDNQ-GADSIACRTFNPELhtpkkmsqGPTLFSCGIMENDRWRDlDRKCPLQIEQ--------------PSA 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181181   80 S-----------GSYSLQWQNESSS-ASKVSGWISELTLNDSFGQPLA-PPTKRHCRSLSEPDELSRCRSPWKPGNSKVW 146
gi 573885141  71 SleclwgvlpgpYQGSRGWVKEAGA-ASAITNLIRDLSLSDAKGSPSAaPPSKRQCRSLSFSDELSVCRPAWRPQGSRVW 149
gi 499020931  70 SleslwdvlpevHTSSAHWDWDVGStSSTITNLLQDLSLTEA-SHSTA-PPSKRQCRSLSCSDELSGCRSSWRPQGSRVW 147
gi 348535524  56 HpssiasvlddsCGLDSLWPTSHSGeSLRGPE--RPFKVFQS-SPP---PPPKRHCRSLSVPEDLSQCRTTWHPSASRVW 129
gi 551487921  55 HqsckayvladsC---DPWPRSCSGePLQGLEvsLTNKSFQS-SPP---PPPKRHCRSLSVPEDLSQCRSTWHPSASKVW 127
gi 432878675  55 ----------dfCIFDSTRSPSHSQpPQQRAGagETV---QS-SPP---PPPKRHCRSLSVPEDLSRCRSTWHPSASKVW 117
gi 768937668   5 YpsfkpallegsGGPDSPWPASRPGkPVQRPDfsVAEKAFQS-SPPp-pPPPKRHCRSLSVPEDLSRCRSMWHPTASKIW 82
gi 941757349  68 SleslwdvlpdvHRTSAHWGWDVGStSSTISSllQDLSLTDA-SHSt-aPPSKRQCRSLSCSDELSSCRSTWRPQGSRVW 145
gi 348508570  70 SleslwdvlpevHTSSAHWDWDVGStSSTITNllQDLSLTEA-SHSt-aPPSKRQCRSLSCSDELSGCRSSWRPQGSRVW 147
gi 591306132  66 Siwec---lpekCQDGALWHREAAT-ACAVTNliKDLSLSDHnGNPs-aPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVW 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181181  147 TPVSKRRCNSGGstTLQRCN--SH-----GGGNLQ----------RSTSI----------------------SLPQNPLT 187
gi 573885141 150 TAVEKRRCHSGG--SVQRGP--CTl---pGYPAMQ----------RSSSF----------------------SLPARSNA 190
gi 499020931 148 TAVEKRRCHSGG--SVQRSSigNMq---sGFAGMQ----------RSSSF----------------------SLPARSNT 190
gi 348535524 130 TPV-KRSCHSGGasSSGSGA--SSlplcgPSSSFPsssi--hssaSPTFF----------------------SLALSSDS 182
gi 551487921 128 TPV-KRGCHSRGasSSGSGA--SSlllcgPSSSFTsssl--hsssSPNFF----------------------SLALSSDS 180
gi 432878675 118 TPV-KHGCHSGG------AA--SSvplcgPSSSFTssih---sssSPTFFslalssdsllswsfpweppdapNTAASLAL 185
gi 768937668  83 TPV-RRDCRSGEvsTSSSAA--SSlpvggAGSSFAsfasslrsssSPTFF----------------------SLALTSDS 137
gi 941757349 146 TSVeKRRCHSGG--SVQR-S--GLgnsqlCFPAMQ----------RSSSF----------------------SLPARSDG 188
gi 348508570 148 TAVeKRRCHSGG--SVQR-S--SIgnmqsGFAGMQ----------RSSSF----------------------SLPARSNT 190
gi 591306132 141 TPVeKRRCYSGG--SVQRYS--N------GFSTMQ----------RSSSF----------------------SLPSRANA 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181181  188 VKhifaasnCDTSPV-QRPSSASSGFVDS-------NEG-SAASNvrwnsag----psefnprRRFSLSQEHITENADLS 254
gi 573885141 191 FPqht--acLPIAGFqPSPPSSSSSSTSE-------ATGdSAAGP------------------RPLSLSHEQICLPEPRG 243
gi 499020931 191 LE-------LPSFTQrPPWSSAFTSLTPS-------SSssvpls--------------sdpssQPLYLSHEQICLPEPRG 242
gi 348535524 183 PVsw----gFPWDPCdTLKGACSASFATP-------SSCsSSPAPltsh----------yvlqRRFSLSPVHIQKSPMVP 241
gi 551487921 181 SLsc----gFPWDPCdTLKGACSASLATP-------SSCsSSPAPlvsh----------silhRRFSLSPVHIQIASVAS 239
gi 432878675 186 PS-----------------------------------SCsSSPAPlvsh----------svlqRCFSLSPVHIQNASVAS 220
gi 768937668 138 PLpw----sFQWDPCqALAGAGSASIATP-------SSCsSSPAPpl---------------qRRFSLSPVHIQDTAAVL 191
gi 941757349 189 QEql----cFPQLSSrP---SAFSGPTPN-------SSDpSAQS---------------------LYLSHEQICLPEAEE 233
gi 348508570 191 LE-------LPSFTQrPPWSSGFTSLTPSssssvplSSDpSSQP---------------------LYLSHEQICLPEPRG 242
gi 591306132 179 LSs-----pYDQAGFhHRFGGQPCQGAPG-------SAT-CGQAGdiwspdptpvgggrldmqRSFSCSHEQFSFAEYCP 245
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 82181181  255 PSANSTP-----------------------TSTPELRR----------------------R---QGLLRCRSQPCVLNER 286
gi 573885141 244 PSADSSP-----------------------DSTPELGR----------------------RagpGGLSRSRSQPCVLNEK 278
gi 499020931 243 PSPPSSP-----------------------DSTPELER----------------------RggqGGLPRSRSQPCVLNEK 277
gi 348535524 242 LPPQPCPssalkcgrsdlehpalspsptsaCSTPSSSR----------------------RdlhPALPRCHSQPCDM--R 297
gi 551487921 240 LHPPPSPahvlahsfsgpehpslcpsptsaCSTPSCSR----------------------RdlhPALPRCHSQPCDM--R 295
gi 432878675 221 SHPQPSPsgfsgveqp-----glspsptsaCSTPSSSR----------------------RglpPALPRCHSQPCDM--R 271
gi 768937668 192 RSPRPSPa---------------------aASAHGCCGgmehpalspsptsacstpsscrRglqPALPRCRSQPCDM--R 248
gi 941757349 234 PSPASSP-----------------------DSTPELER----------------------RggeGGLARSRSQPCVLndK 268
gi 348508570 243 PSPPSSP-----------------------DSTPELER----------------------RggqGGLPRSRSQPCVLneK 277
gi 591306132 246 PSANSTP-----------------------ASTPELAR----------------------Rs--SGLSRSRSQPCVLndK 278
                        410       420
                 ....*....|....*....|....*..
gi 82181181  287 KTRLKRRRDEDV-RWTRPSLDFFKMTR 312
gi 573885141 279 KIGVKRRRPEEA-PEQRPSLDLAKMTQ 304
gi 499020931 278 KTGVKRRRPDDT-HKQRPSLDLAKMTQ 303
gi 348535524 298 KPRLKRRHDPDVlPYPRPVLDFSKMTQ 324
gi 551487921 296 KPRLKRRHDPDVlPCSRPGLDFSKMTQ 322
gi 432878675 272 RPRLKRRRDPDVlPCPRPGLDFSKMTQ 298
gi 768937668 249 RPRLKRRHDPDVlPCHRPGLDFSKMTQ 275
gi 941757349 269 KIGVKRRRPADS-QKQRPSLDLAKMTQ 294
gi 348508570 278 KTGMKRRRPDDT-HKQRPSLDLAKMTQ 303
gi 591306132 279 KVGVKRRRPEEV-QEQRPSLDLAKMAQ 304
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap