Conserved Protein Domain Family
VGLL4

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pfam15245: VGLL4 
Transcription cofactor vestigial-like protein 4
These proteins act as transcriptional enhancer factor (TEF-1) cofactors.
Statistics
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PSSM-Id: 317627
View PSSM: pfam15245
Aligned: 12 rows
Threshold Bit Score: 186.976
Threshold Setting Gi: 551515015
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768945655   8 LSRAASFVHANEEDGEAALRADPRLHSLslsSS-SSSsssslss--------ssssvssHRTGpPPISPTKRKLSGDLGD 78
gi 597748837  14 MDKMNNNIGRLHYDSYDDDSGDSRMHAL---SSsVGS----------------------SRTG-TPVSPVKRKYDDEQVG 67
gi 972947895   9 ITRMNSGFKVYILEGQPSLRTEDRYRHL--------A----------------------HRAGvPPVYPIKRKHSPERGP 58
gi 551515015   9 ITRMSSGFKVYILEGQPHLRGEDRYRHM-------GN----------------------ERPRaPAVFPVKRKRNYERGL 59
gi 734605079  14 LDKMNNNIGILCYEGEAALRGDPRLQSL----S-LSSssssssssssssssssississHRTGpPPISPTKRKLSGDQGD 88
gi 768914549   9 LDKMNNNVGKLYYDG------ESRTPSL---ST-AMA----------------------SITPpPPHCPSKRKYGDEQMD 56
gi 348502633   9 LDKMNNNIGRLHYED------ESKMPSL---SA-TMS----------------------NISGpPPHCPSKRKYGEEQME 56
gi 432866418  14 LDKMNNNIGRLHYED------ESRMPSL---ST-AMS----------------------KITGpPPQCPSKRKYGEEQME 61
gi 597769084  14 LDKMNNNIGILCYEGEAALRGDPRLQPMslsSA-VSN----------------------HRTGpPPISPSKRKHSGDAAD 70
gi 584076293  14 LDKMNNNIGILCYEGEAALRGEPRMQTIpvaSA-LTS----------------------HRTGpPPISPSKRKFGLEPGD 70
gi 612042373   8 lsRAASLVHADDEKREAALRGEPRMQALpvpSA-LTN----------------------HRTGpPPISPSKRKFSVEQGD 64
gi 733907458  14 LDKMNNNIGILCYEGEAALRGEPRMQSLpvsSA-LTN----------------------HRTGpPPISPNKRKLSMDQGD 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768945655  79 SDMD-DNEHVAKMSRLFATQL--K-----PNGDYRSSPisKERSRSPI---------GGVLV------PgALGVHSNHLY 135
gi 597748837  68 SSHDyDNEQMTKMSRLLTSHLgaP-----SNGDSRQEA--WNHCHNPF---------EHASS------A-ISGLHLNHLY 124
gi 972947895  59 A----VEDRAVKVRRSSLALIskEralfgSATRSFQRQ--PSLSPATP---------PQTPTvttttrS-PARRLPSPLY 122
gi 551515015  60 T----LEERRERa----------I-----NRNKMVQRA--GPVP-APFstqqspsspQSPTP------S-PTSPFPPYVY 110
gi 734605079  89 SDMD-DNEHVAKMSRLFAAQLk-P------NGDYRSSPvsKDRSRSPI---------ERVVV------PsALGVHSNHLY 145
gi 768914549  57 DRINcDDDHMTKMSRLFATQLarP-----SVGDNPNEH--WRHSHTLT---------EQMTS------S-SSSLLGNRLY 113
gi 348502633  57 DRFHcDEDHMTKMSRLFATQLgrP-----SAGDNRSEH--WSLSHSPG---------EHVIS------S-SNGLHGNHLY 113
gi 432866418  62 HQIScDDDHMTKMSRLLATQLarP-----SAGSNHTEH--WSLSHSQV---------EHTAS------S-PNGIHGNHLY 118
gi 597769084  71 DDFDcSNEHVAKMSRLFAAQLgkP-----ANGDYRKDP--RDRSRSPI---------ERAAA------P-SMSLHGGHLY 127
gi 584076293  71 DDLDcENDHASKISRIFNPHLnkT-----ANGDCRKDP--RERSRSPI---------ERAVA------P-AVSLHGNHLY 127
gi 612042373  65 DDLDcENDHVSKMSRIFSPHLs-------kNGDCRKEH--RERSRSPI---------ERAVA------P-TMSLHGNHMY 119
gi 733907458  71 DEIDcENEHVSKMSRMFNPHLnkT-----ANGDYRKEH--RERSRSPI---------ERAAA------P-TMSLHANHMY 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768945655 136 GHAhhhhhhhhhhhlvGLA---------GMDQPLALTKNSLvESAR-----SsapimATAPHtVGAAERQQNRPSVITCA 201
gi 597748837 125 PPF-------------PVF---------AMEQPLALTKNSM-DTAR-----S-----ALLSP-VGPAERQQNRPSVITCA 170
gi 972947895 123 AGP-------------P------------MDEPLALIKKPGyCSPTegtvpS-----MDAKPhSPTTTRVQIRPSVITCV 172
gi 551515015 111 YTP-------------------------VSDEPLALIKKPRkDPEN-----------AREKTtASAATQIQMRPSVITCV 154
gi 734605079 146 SHA--------------HHhhhhlaslaGMDQPLALTKNSMvESAR-----SstatmATVPHtVSAVERQQNRPSVITCA 206
gi 768914549 114 SSI-------------SGY---------AVDQPLALTKSSHdMGVA-----A-----REWAAvSGTAERQQNRPSVITCA 161
gi 348502633 114 ASI-------------AGY---------AVDQPIPLTKSSHdIGVR-----G-----TERSViSGTVERQQNRPSVITCA 161
gi 432866418 119 ASI-------------PGY---------DLDQPLALTKSSHnTGIS-----K-----IQKAVvGDAVERPQNRPSVITCA 166
gi 597769084 128 AHM-------------PSL---------AMDQPLALTKNSM-DAAR-----T-----VTISPtVSPVERQQNRPSVITCA 174
gi 584076293 128 TSL-------------PSL---------SMEQPLALTKNSM-DASR-----P-----AGISPtLTPVERQQNRPSVITCA 174
gi 612042373 120 ASI-------------PSI---------TMEQPLALTKNSM-DASR-----T-----VGISPtLTPVERQQNRPSVITCA 166
gi 733907458 128 ASI-------------PSL----------MDQPLALTKNSM-DATR-----T-----VGITPtLTSVERQQNRPSVITCA 173
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 768945655 202 PANNRNCNLSHCPVshSSC-SSLRNSYRR--TNTNTAC--DPVIEEHFRRSLGKNYKE 254
gi 597748837 171 PASNRTCNLSNCHMspNTCnSGVTNMKSK--PNANTVC--DPVIEEHFRRSLGDIYKE 224
gi 972947895 173 S--------SSARA--ASSsPEVRSSPCSs-ASSPPAC--DPVVEEHFRRSLGLHYRE 217
gi 551515015 155 SSVQs---------------PSSRPDVRKshSSGDSKCnyDHVLEEHFQRSLGVNYQQ 197
gi 734605079 207 PANNRNCNLSHCPVshNGC-SSLTNNYRR--INTNTAC--DPVIEEHFRRSLGKNYKE 259
gi 768914549 162 PASNRNCNLSQCHM--NGCsPSPPADQKK--TNANTAS--DPVIEEHFRRSLGKNYKE 213
gi 348502633 162 PASNRNCNLSHCHM--NGCtPSPPTDPRK--AN---VC--DPVIEEHFRRSLGENYKE 210
gi 432866418 167 PASNRNCNLSHCHM--NGCtPCLPADQKR--TNANTVC--DPVIEEHFRRSLGNNYKE 218
gi 597769084 175 PANNRNCNLSHCTVshNGCsPSLPTNYRRp-SNTNTAC--DPVIEEHFRRSLGKNYKE 229
gi 584076293 175 SASARNCNLSHCPIahSGCvAG-PASYRRtpSSATTTC--DPVVEEHFRRSLGKNYKE 229
gi 612042373 167 SASNRNCNLSHCPIahSGCvSSTPANYRRp-PSTTTAC--DPVVEEHFRRSLGKNYKE 221
gi 733907458 174 SANNRNCNLSHCPIahSGCgSAVPA-YRRp-SSTTTAC--DPVVEEHFRRSLGKNYKE 227
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