Conserved Protein Domain Family
FAM196

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pfam15265: FAM196 
FAM196 family
This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.
Statistics
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PSSM-Id: 317646
View PSSM: pfam15265
Aligned: 23 rows
Threshold Bit Score: 464.608
Threshold Setting Gi: 823468294
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768    3 QQSMKVRPVLLKRSSLES---------------VELVKQPHHRRSKSQQVRFKEDGNIKNPTGVTEVNTqtPEDPGVMGK 67
gi 85701578    3 QQSMKVRPVLLKRSSLES---------------VELVKQPHHRRSKSQQVRFKEDGNIKNPTGVTEVNTqtPEDPGVMGK 67
gi 345307855   3 QQSMKVRPVLLKRNSLDS---------------VDFIKAPHHRRSKSQQVRFKEDGANQQPTDVGEADPqeTGNPTLTGK 67
gi 556977092   1 MVSKEASKCLL--TNSESevepaaslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLSA--ALQSDKKDA 75
gi 512828329   1 MVSKEGDKCVL--TSSESeveqavslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLST--VPQTDKKDS 75
gi 584036300   3 QQNTKMRPVLLKRNSLES---------------VALAKQPHHRRSKSQQVRFKEDGTGKPPPGLAGGDVhtTEDPAVMGM 67
gi 332239000   3 QQNMKVRPVLLKRNSLES---------------VEFVKQPHHRRSKSQQVRFKEDGTTKNPTGLAEVDVrtPEDPAVMGK 67
gi 884924862   3 QQSMKVRPVLLKRNSLES---------------VELVQQPHHRRSKSQQVRFKEDGTTKNQTGVAEVDAhtPEDPAEMGK 67
gi 823468294  23 QQNMKMRPVLLKRNSLDS---------------ADFMRHPQHRRTKSQQVRFKEDGVSTK----AELEAnpARDTALTTG 83
gi 637279329  27 MGSKESSKCLL--TTSESevdpatslalemkyaLDPNRQ-IKKRNKALQVRFKDICEAQNEQRDKQLST--LQQIDKKES 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768   68 AQ-----ASRHHHPTTYSLSFPRSH----KAGGfrsisIQTSPSLRKHFPVF--KRKKLTTSKSLVEMPTaspsaiqvng 136
gi 85701578   68 AQ-----ASRHHHPTTYSLSFPRSH----KAGGfrsisIQTSPSLRKHFPVF--KRKKLTTSKSLVEMPTaspsaiqvng 136
gi 345307855  68 TRv-----sRSHHPPGYSLSLPRSRggniRNIA-----IQTSPSLRKHFPVF--KRKKLTASKSLLEMPTeskssiqlng 135
gi 556977092  76 KPisyktAYRKYMTVPARRSIPNVt----KSTG-----VQTSPDLKKRYQTFpmDRKKGNVIKNASTVDT---------- 136
gi 512828329  76 KSls-ykAYRKYMTVPARRSIPNVt----KSTG-----VQTSPDLKKRYQTFplDRKKGNILKNATGVDP---------- 135
gi 584036300  68 TQ-----APRHHPLPAYSLSFPRSq----KAGGfrnmaIQTSPSLRKHFPIF--KRKRLTASKSLVEMPAafqsaiqvng 136
gi 332239000  68 TQ-----ATRHHHPPTYSLSFPRSq----KAGGfrniaIQTSPSLRKHFPVF--KRKKLTASKSLVEMPTasqsaiqvng 136
gi 884924862  68 TQ-----ASRHHHPPTYSLSFPRAq----KAGGfrniaIQTSPSLRKHFPVL--RRKKLTSSKSLVEMPTapqsaiqvng 136
gi 823468294  84 KTe---iFRDHNLLLTQSPTFPRAq----K--GlrniaIQTSPSLRKHFPVF--KRKKLTVSKSLTEMPAepansiqvng 152
gi 637279329 102 KSlsyraAYRKYMTVPARRSIPNVt----KSTG-----VQTSPELKKCYQTFplDRKKGSIIKSIASVDT---------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  137 nlseqdivssdlaflrlaqhledgprrlkiphpflprmPKVQSNGPVSFCLE------SGTWMSSEKATAAIQVPDDICH 210
gi 85701578  137 nlseqdivssdlaflrlaqhledgprrlkiphpflprmPKVQSNGPVSFCLE------SGTWMSSEKATAAIQVPDDICH 210
gi 345307855 136 nlseqdavasdlaylsitppfgeepkrgkrahpffsrvVKVQSNGPLSVAMD------PGTLGKREKATASTQVPEEGPN 209
gi 556977092 137 --------------------------------------FKSQNNGFVIDIKDnkdsesSGEAALCSRKVSDQKEAVLTLH 178
gi 512828329 136 --------------------------------------LKNQNNGFIIDAKDk----nSGDTIQCSR-VNEQVVADLMIH 172
gi 584036300 137 nlseqdtvasdlaclrlaqhledrprrvqvshpflprmSKVQSNGPVSICLE------AGAGRASEKATAAIQVPEDICH 210
gi 332239000 137 nlseqdivssnlaylrlaqhledgprrvkvshaflprvPKVQSNGPVSICLE------AGTWRSLEKATAAIQVPDDIYH 210
gi 884924862 137 nfseqdlmssdlaylrlaqhlvdgprrikvshpflpqlPKLQSNGPVSICLD------AGTWRGSEKATAAIQVPEDIYH 210
gi 823468294 153 tlceadmlsselc--ylrishdledgcrnsevglgqrsSKAQSNGPRY----------SGEFSVSDKTTASTQVPEYIHV 220
gi 637279329 163 --------------------------------------FPSQNNGFLIDVKDkds-niSGEAAHCSKKVTGFVTAEFISH 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  211 SptwearesalspessAEESN---------SIPAL-----ISMCPGDGQRVMTSELERMPPCSNTNSS---ASNMPGT-- 271
gi 85701578  211 SptwearesalspessAEESN---------SIPAL-----ISMCPGDGQRVMTSELERMPPCSNTNSS---ASNMPGT-- 271
gi 345307855 210 S---------------PPCEAkvficgrepTGELSsmiqpSETSRTDGNTVLPSVSEKPSSCPNATSRv-rPHCDSYQa- 272
gi 556977092 179 T---------------NECMN---------VVDQsssgncSEGCKSNDSKSHSFTTESKYLENPEDSNleeLDYQTNDk- 233
gi 512828329 173 S---------------SEDMD---------AIHPlstsncSDACKSTD--SHSCINESPTRQNPANVSleqVICHVHDa- 225
gi 584036300 211 SptwatgelalsqdrsAEISN---------SVHPl-----VDPCPGDGQRGLSSDSERPPSCLNATSG---ANPMPGT-- 271
gi 332239000 211 SpswearesalspdrsAEVSN---------SIHPl-----DDTCPGDGRRVTPPDSEKSTSCLNATSV---ASHTPGT-- 271
gi 884924862 211 SpswetrestvspdrlAQINN---------SGPPl-----VDMCPGDRKKILRSDLESSPSCLNATSG---ANNMSGT-- 271
gi 823468294 221 SfpqdrnlpldapdttTASSN---------SLHSst---aINSNESHENSTLSSDSDRAEPCLSNSVNcsdCNPHSAApe 288
gi 637279329 204 T---------------NERMN---------AIEQpssdncSETCKSTD--LHSCTKEPPSLQNSAASVleePDYQLHDk- 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  272 -EKLTPELLLPKDNPDDKDLGLPSSQSKKMCVpSPPRTHSSPEP---GSRSQPVhL-GRSSDCPASGDNHQDLESlRSSS 346
gi 85701578  272 -EKLTPELLLPKDNPDDKDLGLPSSQSKKMCVpSPPRTHSSPEP---GSRSQPV-HlGRSSDCPASGDNHQDLES-LRSS 345
gi 345307855 273 -DTHDPKSIFPKEDSACTQPAPSSPPLKEACN-PPAPLTPSSSPslfGDLGQST-HlGSASDWVTLSNDNQGLITlAAGN 349
gi 556977092 234 -AKHDAGPL-VAQVPNQYSHSKVLKVEHATVH-LPESGSETtHPqlsNSLTETE-----CSQNPAVQEEQNRTVHlNGVQ 305
gi 512828329 226 -SKYDRGPL-GNIHSNQSGHIKVLLKEEATIH-SPTLNPNLtDPeesNPGNDSE------QTSTSAEEETKRTAHlNGLQ 296
gi 584036300 272 -GKLKPELLLPKDNSGDTDFDPLSLLSKEACVpSPPRTHGSpSP---GSHGQPAhP-GGASDCSSSSSHHQDPAPlKPNH 346
gi 332239000 272 -EKLKPELLLPKDNSDDKDLGPLSSQSKETCVpSPPRTHSSpSP---GSHIQPAhP-GRASDCPSSSNNHQNLVSlKTNS 346
gi 884924862 272 -GKLKPELLLPKDNSNDKGLGPLSSQSKETCIpLSPRTHSCpAP---DSHIQTAhS-GRASDYPASSDGHQNPVTlKSSS 346
gi 823468294 289 vQKSESEPPAASKDASSKESTPLS----------PSSNHSS-PPcflRECHQAGeH-KPGSSCVTLPSDDCPPVSlPSSD 356
gi 637279329 257 -AKHHTGLL-DSEEANLSTHGKVFKTEVASVY-LPASSSHAsQTdlqNSAAAGNdW-FLC---PA-EEDKKRTVHlNGLQ 328
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  347 AS--KS-VPVCWEHVT-------K--------LPSQSdtpelqtgvgseqlPASIPRQENRAQSSR-EIGGSNHSHLAQG 407
gi 85701578  346 SA--SKsVPVCWEHVTklp-sqsD--------TPELQtgvg------seqlPASIPRQENRAQSSR-EIGGSNHSHLAQG 407
gi 345307855 350 AS---KsAPSCQGEMEkns-tqsDapefktglESFHI--------------QPSLPKKEIKAQTNK-EIREINQIHLAHG 410
gi 556977092 306 SPs-VT-GQVYSMQTHcqs-thnN--------EQPLQ--------------TTTLPVEDNQPSQTAvAVSEVCQQLMPHT 360
gi 512828329 297 TQd-VH-AKACTAQAQcqatecnN--------EQTLQ--------------INVLPAGKNAPCQIAvALSGECQQIVPHT 352
gi 584036300 347 PS--RP-APACQERTT-------R--------NPTQSdtlefrncpgndhlPSSRPRRETKLQSNR-E---LNQIHLARG 404
gi 332239000 347 AS--KS-APGCQEQTA-------N--------NPTESdtlefpncpgsnhlPSSVPRSETKLQSTR-EISDINQIHLARG 407
gi 884924862 347 AS--KS-APLCQEKMT-------M--------NPTQSdilelrsrpgsdqlSPSLPNSETKYQSNR-EISGINQIHLARG 407
gi 823468294 357 AS--KP-CLSCNSEIQ-------K--------SSTHSdvsqcnsclegfhiKSYPPRNEINPQSNK-EINEINQIHLAHG 417
gi 637279329 329 SQavSA-AQACSMQAQcqs-tecN--------EQTLQ--------------IHVSPMEGKQPCQTAvAVSEGCQQIVPHT 384
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  408 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKAHALTEGr------------------------------NFYRTGQ 457
gi 85701578  408 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKAHALTEGr------------------------------NFYRTGQ 457
gi 345307855 411 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKARALTEGr------------------------------NFYRTGQ 460
gi 556977092 361 EVVDLKAQLQLMENLISSSQETIKVLLGVIQELEKGEAHREG-------------------------------LSYRTGQ 409
gi 512828329 353 EVVDLKAQLHTMENLISSSQETIKVLLGVIQELEKGEAHREG-------------------------------LSYRTGQ 401
gi 584036300 405 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKARALTEGr------------------------------NFYRTGQ 454
gi 332239000 408 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKARALTEGr------------------------------NFYRTGQ 457
gi 884924862 408 ELCDLQGRLQSVEESLHSNQEKIKVLLNVIQDLEKARALTEGr------------------------------NFYRTGQ 457
gi 823468294 418 ELCALQGRLQSVEESLQSNQEKIKVLLNVIQDLEKSRALSEGr------------------------------NFYHTGQ 467
gi 637279329 385 EVVDLKAQLQMMENLISSSQETIKVLLGVIQELEKGEAHREGycylgenlmsksdldyvmkasshllrldplkLSYRTGQ 464
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81884768  458 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHEV--LQSLEEAEPTEEAPSPPKSPAEAPVPEKQDlRRKSKKVKKKC 531
gi 85701578  458 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHEV--LQSLEEAEPTEEAPSPPKSPAEAPVPEKQDlRRKSKKVKKKC 531
gi 345307855 461 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHQV--LKTLDQVEQIPEMSPPQQVPVDPPVPEKQDiRRKSKKMKKKC 534
gi 556977092 410 DTANCDTCRNSACIIYSVELDFKQQ----EDKLQPV--LRKLHPNKETQVPSLPYTPEGY-STPKQKS-KTESKKHGRWK 481
gi 512828329 402 DTANCDTCRNSACIIYSVELDFKQQ----EDKLQPV--LKKLNPVEESQVAPLPYPAESYTSTPKQKS-KTESKKHGRWK 474
gi 584036300 455 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHEV--LQSLEEAEPVEEPCPPPKSTAEPPVPEKQDlRRKTKKVKKKC 528
gi 332239000 458 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHEV--LQSLEEAEPVEEASPPPKSPAEPPAPEKQDlRRKTKKVKKKC 531
gi 884924862 458 DLNNCSTCQNTACIIYSV------EyrpyTSRQNIFkxMQIt-EIEPVEEPSSPLKSPAEPPAPEKQDlRRKTKKVKKKC 530
gi 823468294 468 DLNNCSTCQNTACIIYSVEYDFRQQ----EGRFHQI--LKTLDNAEQNPASASPQKPLPDPPAPEKKElRRKTKKVKRKC 541
gi 637279329 465 DTSNCDTCRNSACIIYSVELDFKQQ----EDKLQPV--LRKLHPIEETQVAPLPYSQESYSSTPKQKS-KTESKKHGRWK 537

                 ....
gi 81884768  532 FWWI 535
gi 85701578  532 FWWI 535
gi 345307855 535 FWWI 538
gi 556977092 482 LWFL 485
gi 512828329 475 LWFL 478
gi 584036300 529 FWWI 532
gi 332239000 532 FWWI 535
gi 884924862 531 FWWI 534
gi 823468294 542 FWWI 545
gi 637279329 538 LWFL 541
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