Conserved Protein Domain Family
NHS

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pfam15273: NHS 
NHS-like
This family of proteins includes Nance-Horan syndrome protein (NHS).
Statistics
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PSSM-Id: 317649
View PSSM: pfam15273
Aligned: 21 rows
Threshold Bit Score: 556.271
Threshold Setting Gi: 768936362
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   349 RLHHTRDSGCQTDDFLIActaAPSRRRIRAQRGhQGIPASLSH---STGNISSLGDQSDSTYTSVTthGGRLRSRSLPRE 425
gi 1032956797  234 QRSETRDSSCQTEDVKVI---PPSMRRIRAHKG-LGIAAQMSHlpgSSGNMSVLSDSAGIVFPSRL--NNDADFHSLPRS 307
gi 675654595    96 QRSETRDSSCQTEEVKVV---PPSMRRIRAQKG-QGIAAQMGHfsgSSGNMSVLSDSAGIVFPSRL--NSDAGFHSLPRS 169
gi 973191624   377 gRSTTKDSGCQTDDILIA---APSRRRIRAQRG-QGIPTSLSH---STGNITSLPDNSDAMFAATV--GSRLRSRSLPRE 447
gi 765114919   298 RLHHTRDSGCQTDDFLIActaAPSRRRIRAQRGhQGIPASLSH---STGNISSLGDQSDSTYTSASvhGGRLRSRSLPRE 374
gi 992224152   321 RNLNTKDSGCQTDDFLIA---APSRRRIRAQRG-QGIPASLSH---STGNITSLPDRSDTMYTAAS--GTRLRSRSLPRE 391
gi 542212296   341 SHLNTRDSGCQTEDFLISg--APSRRRIRLQRG-QGVSLSLSH---SAGNISSLPETSDAMFSASV--GAHLRSRSLPRD 412
gi 551498371   267 SHLTTRDSGCQTEDFLTSg--APCRRRLRVQRG-QGVSLLLSH---SAGNISCLPDSADPMFSSSV--EARLRSRSLPRD 338
gi 914895808   471 RRSGTRDSECQTEDILIA---APSRRRIRAQRG-QSIAASLSH---SAGNISALADKGDTMFTPTV--SSRTRSRSLPRE 541
gi 637282263   124 RRSGTRDSECQTEEILIA---APSRRRIRAQRG-QSVVASLSH---SAGNILVLTDNGDAMFTTSV--SNRVRSRSLPRE 194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   426 GGRlmds-----------dedD---------------------DDDNYdd---ddEdeelspyeaedfipsGPSPRMKMM 470
gi 1032956797  308 GAR------------------A---------------------STYSLesr-mgaL---------------GSADNMDDT 332
gi 675654595   170 GAR------------------A---------------------NIQSLepr-lgpL---------------GPAGDMDGT 194
gi 973191624   448 GGRlvded---------hdsdE---------------------ELSPYete-eflP---------------GP-ER---- 476
gi 765114919   375 GGRl----------------iDsdddddddddddnyddddddeDLSPYeaedfipS---------------GPSPRMKMM 423
gi 992224152   392 GGRlrdedhddsddddddeddE---------------------ELSPYeae-dflP---------------GPGQR---- 430
gi 542212296   413 TSRlldngh------ndsddeE---------------------DLSPFdte-gflT---------------GSRKL---- 445
gi 551498371   339 SSRmmmilmdn--erndsdeeE---------------------ELAPFdse-gflP---------------GRRER---- 375
gi 914895808   542 GNRggdae---------pkvgA---------------------KPSTYeeeepfvG---------------DH-ER---- 571
gi 637282263   195 GARanevd--------hhntsA---------------------KVSAYeae-hflT---------------SQ-ER---- 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   471 MMKDEEESTDDQAAPEPLqlgs-----------------lkrEHSWMERGRSRLPRK-AD-------------------- 512
gi 1032956797  333 FRHQGGSSQGHENFAHLGga---------------------sRSGMLLRPKSQQLRFsESeniaspacvvsphaaystsv 391
gi 675654595   195 FPYQRGHPQADENSGHLGga---------------------sRTGTLMRPKSQELRHfESenvtspacvvsphagystsi 253
gi 973191624   477 VLKDEEESTDDQAMPDHQlvglkck-----------qhvgspDHNWNERGRSRLPRK-VD-------------------- 524
gi 765114919   424 MMKDEEESTDDQAAPEPLqigslkrqqrsgdrdrgcggggspEHSWMERGRSRLPRK-AD-------------------- 482
gi 992224152   431 ILKDEEESTDDQAMPELQlgslkrm-----------qhsgspENSWIERGRSRLPRK-AD-------------------- 478
gi 542212296   446 TLKDEEESTDDQAMSEHQlgslkyk-----------qlsqspERSWMERTRAHLPRK-AD-------------------- 493
gi 551498371   376 ILKEEEESADDRAMSERQlgglkfa-----------qlsdspERSWMERTGAQLPRK-AD-------------------- 423
gi 914895808   572 TPNDCSEAPSSPSTQEHQpalglac----------sqhlhspQHKLSERGRSRLSRMaAD-------------------- 621
gi 637282263   225 ISAKSKDAINNPCLQEHHpiglkcs-----------qhlhspDHNSNERGRSRLSRM-VD-------------------- 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   513 MGSCEISSSSDTFSspIHSVSTAGG-LGSHVDH-------------------KEDHQSSSGNWSGSSSTCPSQTSESIpP 572
gi 1032956797  392 IPNATLLSSSEVIV--IHTAQSMGQ-LDSRMPGsstyskikprdrpmprcslKDDHQSPSHHWNERH-IIHSQALASS-A 466
gi 675654595   254 IPNAKLSSSSEVIA--IHTAQSAGQ-LESR-SSsslhakiksrdhlisrhavRDDHQSPSRHWNEGHTTMLSQALDPQ-S 328
gi 973191624   525 MGSCEISSSSDTFSspIHSISTTGV-LGSQIDH-------------------KEDHQSSSGNWSGSSSTCPSQTSETIpP 584
gi 765114919   483 MGSCEISSSSDTFSspIHSVSTTGV-LGSHVDH-------------------KEDHQSSSGNWSGSSSTCPSQTSETIpP 542
gi 992224152   479 MGSCEISSSSDTFSspIHSVSTTGV-LGSQIDH-------------------KEDHQSSSGNWSGSSSTCPSQTSETIpP 538
gi 542212296   494 MGSCEISSSSDTFSspVHCVSAAAV-LGGQIDH-------------------KEDHQSSSGNWSGSSSTCPSQTSETLpP 553
gi 551498371   424 MGSCEISSSSDTFSspVHSVSAAGV-LGSQMDH-------------------KDDHQSSSGNWSGSSSTCPSQTSETIpP 483
gi 914895808   622 SGSCDISSNSDTFGspIHCISTAGVlLSSHMDQ-------------------KDDHQSSSGNWSGSSSTCPSQTSETIpP 682
gi 637282263   273 SGSCDISSNSDTFGspIHSISTAGVlLSSHMDQ-------------------KDDHQSSSGNWSGSSSTCPSQTSETIpP 333
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   573 PSSPPLtgSSHCDSELSlntvpnaIDE--GFSLdpsyhsdlrpqgQGHRSSSFTSSATDQLDDAGVST------ASEGEW 644
gi 1032956797  467 SSATTL--LSLCDSEVPlnapasrENGsqAIPY------------HCRNNLNFPAHLPEVDGKSESSYsgdrghGSSEPW 532
gi 675654595   329 SGAPTL--LSLCDSAVSlnapanrENGsqAMPY------------NCRNNLAFPAHPQDVDGKSESSYsgggghSSLEPW 394
gi 973191624   585 AASPPLtgSSHCDSELSlntaphvNDDptGFIIdpyq----tdkvRGHRASSFTSTVTDLLDDPGMSN------VSDGEW 654
gi 765114919   543 PSSPPLtgSSHCDSELSlntvpnaIDE--GFSLdpsyhtdlrpqgQGHRSSSFTSSATDQLDDAGVST------ASEGEW 614
gi 992224152   539 TASPPLtgSSHCDSELSlntgshiIDDttGFIIdpyhm--drtqgQGHRSSSFTSSATDQMDDAGVST------ASDGEW 610
gi 542212296   554 AASPPLtgSSHCDSELSlnaathtNDDqtGFLLdhy------qglRTQRAGSFSSTAMDILEEVGVST------PIEGEW 621
gi 551498371   484 AASPPLtgSSHCDSELSlntathtAEDqtSFLLdny------qglRTQRAGSFSSAAMDVLEEAGVST------PMEGEW 551
gi 914895808   683 AASPPLtgSSHCDSELSlntaphaNEDtsVFVTeqynd--hldkvRGHRANSFTSTVADLLDDPSNSN------TSDSEW 754
gi 637282263   334 AASPPLtgSSHCDSELSlnivpsaNEDsnVFITehytd--qidkiRGHRASSFTSTVADLLDDPNNSN------TSDSEW 405
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   645 AYPPDQDQTDqd--tEPDQTRTLNRSQDLPQEYNSKEGPenqvcfsdiKTSNVDKDPSCTYSPDTEGFYsSSEHFGDCNQ 722
gi 1032956797  533 ECRASSNGQA-----SPLKPHLATPGCSTPTSNMSSCSL---------DQTSVKEDARSLYSEDHDGYS-VTTHSDSGHE 597
gi 675654595   395 EYKASGNGRA-----SPLKPHLATPGYSTPTSNMSSCSL---------DQTSNKEDAGSLYSEDHDGYC-TSLHADSGHG 459
gi 973191624   655 NYLHHQHDKScrqdfSPQRSREDESSLECPSFTSMATyes-----fmdKPPSEKADSSSHFSVDTEGYY-TSMHFDCGLK 728
gi 765114919   615 TYPAEQDQVDpd--qDSDQTHILTPSHGTVQDYSLKQHLdnet-tfneKANSMEKEPGSQYPSDPHYFYsSSVNFGESEQ 691
gi 992224152   611 NCNQDQQDHPcpqdfSPKHSREDESGVSCPSYSSGETyes-----fsgQPPAEKLESSSHYTVDTEGFY-TSMHFDCGLK 684
gi 542212296   622 SYPNPEPPGSqg--fSPEPSREPGSSLGCPSFTSMATCess----fsdKPPSEKADTVSHYSVDNEGYY-TSMHFDCGLK 694
gi 551498371   552 DFPNAEPSSSqg--fSPEPGREAESSLGCPSFTSMATCess----fsdKPPSEKADTVSYYSVDTEGYY-TSMHFDCGLK 624
gi 914895808   755 NYLHHHHDASchqdfSPERPKAD--SLGCPSFTSMATyds-----fleKSPSDKADTSSHFSVDTEGYY-TSMHFDCGLK 826
gi 637282263   406 NYLHHHHDAScrqdfSPERPKTD--SLGCPSFTSMATyds-----fieKTPSEKADTSSHFSVDTEGYY-TSMHFDCGLK 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   723 GYRGYm-cNYADLGPDCAQSNPTAAP-----YPQHITGLRAGTMTLG-RTCHSLRKPKVKPPPPKRSSSLKEpicgvdie 795
gi 1032956797  598 TGNVYn--ISDGFGNPRHSMVNVFDG-----RAQRSQGDQANHQDKSlSRNISLRKAKKPPLPPCRTDSLRR-------- 662
gi 675654595   460 SGNLCn--SSDGFGNPRHSVVNVFDG-----RAQKNQGDRSNYQDKSlSRSISLKKAKKPPLPPSRTDSLRR-------- 524
gi 973191624   729 ASKSYi-yNYAAMGTDCGQSANVAPS-----MDGYPQQEYQGHRTTG-RQSLSFKKPKVKPAPPKRSSSLKKtssg---- 797
gi 765114919   692 SFRGYt-yNYADPGADCGQSNIIAAPlshggYPQPTAEFRAGTMTLG-RTFRPLRKLKVKPPPPKRTSSLREtssrvdig 769
gi 992224152   685 GSRSYy--NYAAIDPDCGPSGNIAPG-----MGEYPQPDYRGVSTLG-RQCLSLRKPKAKPPPPKRSSSLKEtsss---- 752
gi 542212296   695 GSRSFtynNYAPSGTDCGLS------------------DSSGHMTLG-RRCLSLKKPKVKPSPPKRSSSLRKicse---- 751
gi 551498371   625 GSKSFt-yNYANPGSDCGLS------------------DMSGHLTLG-RRCLSLRKSKAKPSPPKRSSSLRKicse---- 680
gi 914895808   827 GNKSYv-cHYAAMGPENSQG--VGPG-----LPDCAWQDYLDHRRQG-RPSISFRKPKAKPTPPKRSSSLRKsdgn---- 893
gi 637282263   478 GTKSYi-cNYAAVGSESGQNASVASS-----FTNCTWQDYVNHRRHG-KQSISLKKPKAKPAPPKRSSSLRKpdss---- 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   796 tdtqTEQDQPKMASE-QEDT--LSSTDTNLELeqDLESAPEPLQTACLVAEPLGTWGMGLHETVDIVE-PMSFSSAD--- 868
gi 1032956797  663 ----VPKKNSQSNGQ-MLNEslIASLQHSLQQ--SLPGKGGSSPSQSPCSDFEEPWLPRSRSQSIVSEgSSMTSTTTpnv 735
gi 675654595   525 ----IPKKSSQSNGQ-VLSEslIATLQHSLQL--SLPGKGGSSPSQSPCSDLEEPWLPRSRSQSTVSAgSSMTSATTpnv 597
gi 973191624   798 -anvPDKKEPKINSG-QPLP--LSSREMKLQL--DLASSPGQLENPTLGDEPAEPW--EVGNAGEVTD-ATLFGSTD--- 865
gi 765114919   770 tdtqADQDPPKMVCE-QELN--LSSTDMKLELelELGGAPEPLQTSCLGAEPMGTWGMGLSQTMDLVE-PMSFSSAD--- 842
gi 992224152   753 -vdvPEQNEPKITNE-LPLP--LSSREMRLQL--DLAGSSGQLETAGLCDEPIGAW--GVENVREMLDcSSPFSSSD--- 821
gi 542212296   752 -gniPVKKEPKITCG-QQLP--LSAKERKLQL--AFSGSPAHTENSSLVRETRVGW--GVEGSADLPD----LVSTD--- 816
gi 551498371   681 -ghiPEKREPKITGT-YRHPvsLSSKERRMQL--ALSGSPGLMENSSLGREPLEVW--AMEGTSDLTD-LGILSSKD--- 750
gi 914895808   894 -advPEKKEPKISSG-QHLP--HSSREMKLPL--DFSNTPSRMENVNLPTKQEPSW--VNQSEHGMKE--PQLDTSD--- 960
gi 637282263   547 -tdlPEKKEPKISSGqQHMP--HTSREMKLPL--EFANTPSRTENANLPSKQELPW--DNQDESGLKE--LSYDTMD--- 614
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   869 ------THSFKDEGAVQSDYADLWLHNSDLKC-NNGEYTSMSNSSTATGTTVMECMKSPDSssssteastqalskaSDTR 941
gi 1032956797  736 yslcgvTPSQSDTSSVKSEYTDPWGYYIDYTSfQEEPGNPTGGCSASSEAPTGNGPVCHIQ---------------EGSR 800
gi 675654595   598 yslcgvTPSQSDTSSVKSEYTDPWGYYIDYTGmQEDPGNPAGGCSASNGAPTGNGPVRHVQ---------------EGSR 662
gi 973191624   866 ------NHSFKDEGAVQSDYADLWLLN-DLK--SNDPYRSLSNSSTATGTTVIECIKSPESsesq--------tsqSGSR 928
gi 765114919   843 ------THSFKDEGAVQSDYADLWLHNSELKS-SNGEHTSMSNSSTATGTTVMDCMKSPDSsssstdtqiqpivqpTETK 915
gi 992224152   822 ------THSFKDEGAVQSDYADLWLLS-DLK--SNDPYRSLSNSSTATGTTVIEFVKSPESvett--------vcrPRSR 884
gi 542212296   817 ------THSFKDEGVLQSDYADLWLLN-DLK--STDPYRSLSNSSTATGTTVIECIKSQDSsesq--------tsqSGSR 879
gi 551498371   751 ------AHSFKDNGIVQSDYADLWLLN-DLK--SSDPYRSLSNSSTATGTTVIECIKSQESsesq--------tsqSGSR 813
gi 914895808   961 ------IPPFKDEGAESTHYADLWLLN-DLK--TNDPYRSLSNSSTATGTTVIECIKSPESsesq--------tsqSESR 1023
gi 637282263   615 ------IPSFKDEGAEQSHYADLWLLN-DLK--SNDPYRSLSNSSTATGTTVIECIKSPESsesq--------tsqSGSR 677
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768936362   942 AASPPLPSg--DFKLGSPEKLAGLASPSSGYSSQSETPTSTLPSssaAFFPGPQSPSTGKR--KPKVPERKSSLPSLQHF 1017
gi 1032956797  801 GPMPQVPGgsvKPKITSPEKSQRVTSPSSGYSSQSNTPTALTPV---PVFLKSMSPANGKGkaKPKVPERKSSLISSVSI 877
gi 675654595   663 ATMPQVPSasvKPKIMSPEKSHRVISPSSGYSSQSNTPTALTPV---PLFLKSMSPANGKGkpKPKVPERKSSLISSIST 739
gi 973191624   929 ATTPSLPSvenEFKLASPEKLAGLASPSSGYSSQSETPTSSFPS---AFFPGPLSPTSGKR--KPKVPERKSSLSSLQQQ 1003
gi 765114919   916 TTSPTVQPg--DFKLGSPEKLAGLASPSSGYSSQSETPTSTLPSssaAFFPGPLSPSTGKR--KPKVPERKSSLSSLQHF 991
gi 992224152   885 PTSPTLPPpesDLKLGSPEKLAGLASPSSGYSSQSETPTSSFPS---AFFPGPLSPNTGKR--KPKVPERKSSLASLQQQ 959
gi 542212296   880 ATTPSLPSvegDFKLTSPEKLASLASPSSGYSSQSETPTSSFPS---TFFPGPLSPSSGKR--KPKVPERKSSLSSLSLQ 954
gi 551498371   814 ATTPSLPSvesEFKLTSPEKLAGLASPSSGYSSQSETPTSSFPS---TFFPGPLSPATGKR--KPKVPERKSSLSSLSLQ 888
gi 914895808  1024 ATTPSLPSvdnEFKLASPEKLAGLASPSSGYSSQSETPTSSFPT---AFFSGPLSPGGSKR--KPKVPERKSSL-----Q 1093
gi 637282263   678 ATTPSLPSvenEFKLASPEKLAGLASPSSGYSSQSETPTSSFPT---AFFSGPLSPGGSKR--KPKVPERKSSL------ 746
                          810
                   ....*....|....
gi 768936362  1018 SRDGTLISSGYRRD 1031
gi 1032956797  878 SSSSTSLSSNTSTE 891
gi 675654595   740 SSSSTSLSSNTSNE 753
gi 973191624  1004 QQP-RDGSTSSkkd 1016
gi 765114919   992 PRDVATISSCYKRD 1005
gi 992224152   960 SLALRDPGSSIRRD 973
gi 542212296   955 SLSSRDGAtskrdl 968
gi 551498371   889 ARSSRDVATSkkdl 902
gi 914895808  1094 QPSLKDGTLslskd 1107
gi 637282263   747 QQTSKDGSVSlnkd 760
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