Conserved Protein Domain Family
BORA_N

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pfam15280: BORA_N 
Protein aurora borealis N-terminus
This family of proteins is required for the activation of the protein kinase Aurora-A.
Statistics
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PSSM-Id: 317655
View PSSM: pfam15280
Aligned: 16 rows
Threshold Bit Score: 169.589
Threshold Setting Gi: 308503510
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353231685  18 EFGITTPS--GGLIFNPFHK-EFLSRV-EQVNfSPGIFAYNPSPISK-SGSRkttpnrikTPFILSPDIQGELFPVDIDE 92
gi 260826586  23 sslylTAS--QGSTINPFEV-GVEDRLhLTAL-SPSVFDKVESTPSS-GSTE----------FRWSIDQMAILHPADIPM 87
gi 308503510  99 SMSAELSSfvANNSPNPFDS-ILLNSLhKSINfSPRLILSSQESGSQ-QKGG--------ERFQWSVEQLAILKPAHISE 168
gi 268533100  94 SMSAELSSfvANNSLNPFDS-IIMNSLhKSLDfSPRFVLSKE-SGSQ-QKSD--------GKFQWSVEQLAILKPAHISD 162
gi 312071326 126 SIRPQSNStaRSHITNPFDS-DIMGSLcATTY-SPNLFNNSKRNVEC-ETPE--------KSFRWSIGQMADLHPAVIDE 194
gi 195019503  76 VCTPPPKR--LQKVRNPFEG-ALTERLhLPLIaSPSLF---QCRSRTpQLSS--------TQFEWDIEEVSQLKPADVEP 141
gi 195440200  60 VCTPPPKR--LQKVRNPFET-ALAERLhLPLIaSPSLF-----RSRTpQLSS--------TQFEWNIDEVSQLKPADVEP 123
gi 357609979  12 KATPPT----KGKIRNPFDK-VLIEKLhKPIC-SPGMCKIYKKKNRG--------------SFRWDIDQACVLVPTEIVA 71
gi 821476602  10 QITPETPG--KITVLNPFESpSDYSSLqEQIVsSPSVFKSTK----S-SSTP--------GKFRWSIDQLAVINPVEIDP 74
gi 637280487  10 QITPESPG--HLRVHNPFESpSDYSHLrEQIVsSPTVFKSTK----P-SETP--------GKFRWSIDKLALINPVEIDS 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353231685  93 NPVLQLk---lQEKLDTQCDDEIQNRIHSFFKSHL-IAPSPdtvvfds-------------------------------- 136
gi 260826586  88 EEVSRQhd-tlHLTHDRDVEEKAQRAINQFFSQSV-VVPSPwtqssprrktrmigqqggtes------------------ 147
gi 308503510 169 DEIAAS-----YRSPIPEIEEKIQEALNEYWSNNVsYIPSPdgprfvnlthrdgtvttirygeeaa---ssegntpslan 240
gi 268533100 163 DEIAAS-----YRSPIPEVEEKIQEALNEYWSKNVsYIPSPdgprfvnlnhrdgtvttiqygaeastsgtsdgntpclan 237
gi 312071326 195 TEsmc----qmCQTPDPAEEAQINNAIDKFWASQKyVLPSPyfakestnsaqdc-------------------------- 244
gi 195019503 142 HETQFH------DSPDAEQESKAQLAISAFFKESH-IVPSPvdcplrkqr------------------------------ 184
gi 195440200 124 HETQFH------DSPDAEQESKAQLAISAFFKESY-IVPSPvdcplrk-------------------------------- 164
gi 357609979  72 CNSQFE------PSPDIALEKIAEEANEKFFSQEM-VMPSPmetskkv-------------------------------- 112
gi 821476602  75 EDIHRQalylsHSGIDKDVEDKRQKAIEEFFTKGV-IVPSPwtdhegkqvsqchsskcidi------------------- 134
gi 637280487  75 EDICRQalylsQARIDKEMEEKRQKAIEEFFTKSV-IVPSPwtdhsgkqvsqlnstkcmd-------------------- 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 353231685 137 ------ptkstplGKKKKNSYLlgNNSSCMCEVAVQTSISMP--PSFDFESVMQiAF--EQNHSMknlSAAKSSVtlsit 206
gi 260826586 148 --------------adqhasftetaakqgtthasfQTLLTLP--PDFDLEAILGpEH--FSTPQPvpeDQEQEVLstssl 209
gi 308503510 241 ivrrkeavkaayaTSSPKQRPR--KNLRQVRNRVCQTELTIPpgLDLDLKKLLGeNFv-YQDQE----AEDEEVFnisvc 313
gi 268533100 238 lvrkkeavkaayaTSSPKQRPR--KNIRQVRNRTSQTELTIPptMDLDLKKLFGeSFv-YQDEQE---DDDEEVFnisac 311
gi 312071326 245 -spnliqrsrafvQESPLARPVvaRSIESKKSVEVQTMFTFP--PNLDLMRLLG-NC--FQH------EEGEVAIfeanl 312
gi 195019503 185 ----iilneiaqnDNTPISNRSkpRS----RDSEVQTELSLPpvLPKALEEALR-PY--LQSHLAgssRRLKSGSgldlf 253
gi 195440200 165 -------hriileDNTPISNKSnsNATRRRRDCESQTILSLPpvLPKALEEALK-PY--FQPHLAggiKKDRSSDpfnss 234
gi 357609979 113 -------iplqtsLETSIQINTsiKESIVTRDVSAQTVLTLPpkLPPELENLLK-TYytYTQDQSqniFDEYEVTangsl 184
gi 821476602 135 --------------dnvspigreltlpsgknnvaCQTLLSLP--VDFNLEKLLG-EY--FRADEFa--DQSQENLssssl 193
gi 637280487 134 ----------------vspigrevvvqpgksnasCQTVLSLP--VDFDIEKILG-EY--FKADELa--DQSQESLstssl 190
                        250       260
                 ....*....|....*....|....*
gi 353231685 207 s-----nkmitNDDKSDSQRKSDPF 226
gi 260826586 210 r-----rklffQGDLSTPFSPVKSS 229
gi 308503510 314 snfstrrrlfsNGGGQQEDGaedva 338
gi 268533100 312 snistrrrlfsAGGQDDVGNddvnn 336
gi 312071326 313 slntlrrklflDALSSHANTENGSE 337
gi 195019503 254 ns--smrrklfDLKNVIVLGEMEQE 276
gi 195440200 235 m-----rrklfDMHNVVVL---ECE 251
gi 357609979 185 r-----rklffEERDVEHSDHYDSE 204
gi 821476602 194 r-----rklflDGN--GSMSDSLSp 211
gi 637280487 191 r-----rklflDEN--GSLSSGNSS 208
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