Conserved Protein Domain Family
Lbh

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pfam15317: Lbh 
Cardiac transcription factor regulator, Developmental protein
The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.
Statistics
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PSSM-Id: 317690
View PSSM: pfam15317
Aligned: 12 rows
Threshold Bit Score: 89.1028
Threshold Setting Gi: 224051759
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 965863485   1 MALVPGSSEdg-pwP-KDSPGSSQHAESPRL----TTPLWKDRGEIDRVEGHQDvqvstlppcvlllahpllwpsspvvp 74
gi 586552494   1 MDLVPESSEdg-pwP-RDSPGSFQHPESARL----TNPLWKDRGEIDRVEDHQDiqvv---------------------- 52
gi 611983017  94 MTEVMMNTP-----T-MDEIGLNNQKD--SI----SYQIFPDPSDYECICKLKD-------------------------- 135
gi 58332630   18 MTEVIMNTQ-----P-MDEIGLSPRKD--------SYQIFPDPSDFERCCKLKD-------------------------- 57
gi 354468322  18 MTEVMMNTP-----S-MEEIGLSPRKD--GL----SYQIFPDPSDFDRCCKLKD-------------------------- 59
gi 348510907  19 MTEVMINST-----P-MEDMRLSPSKD--RL----SFQIFPDPSDFDRCCKLKD-------------------------- 60
gi 565311171   1 MTEVMNTRE-----PvMEEFTLSQPEEEGGT----STQAFPDA--HEKYPKLSK-------------------------- 43
gi 224051759   1 MTEVMNTRE-----PvMEEFVLSQTPE---EeggpSSQAFADS--REKYPKLSK-------------------------- 44
gi 686735981   1 MALVPGRSKvdglwT-RNSPGSSQHPESPRL----PNPLW-DRGKIGKVEGHQHiqdf---------------------- 52
gi 831240560   1 MALVPGSSEedgpwT-RDSPGSSKHPESPRL----MNSLWKDRGEISRVQGYQDfqvv---------------------- 53
gi 655882054   1 MALVPGNSEedgpwP-RDSAGSSRCPEGPRL----TSSLWKDTGAIGRAEGPQDvqav---------------------- 53
gi 554790408   1 MALVPESSKdg-swS-GDNPDSPWHPESPQL----ANPLSKNREETGRCEDHQDvevs---------------------- 52
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 965863485  75 iqvtcpqtRLPSIVVEASEVN-EESGELRWPHQELLLLTDDeEEEAEVFFQDQS 127
gi 586552494  53 ----sqktHLPSIVVEASEIS-EESGELRWPHEELLVLTDD-EEEAEGFFQDQS 100
gi 611983017 136 --------RLPSIVVEPTE-GeVESGELRWPPEEFVVHEDG-KEKKEEKEKENK 179
gi 58332630   58 --------RLPSIVVEPTE-GdVESGELRWPPEEFVVDEDK-EGSCDQTKKENE 101
gi 354468322  60 --------RLPSIVVEPTE-GeVESGELRWPPEEFLVQEDE-QDNCEETAKEKK 103
gi 348510907  61 --------RLPSIVVEPTE-GeVESGELRWPPEEFLVSEEE-EEDEEEEEEEQN 104
gi 565311171  44 --------RLPSIVVEPSEMGdVESGELRWPPEDLKSMEDK-KALAAQRSCAQQ 88
gi 224051759  45 --------RLPSIVVEPTESGeVESGELRWPPEDLKSAEDK-GLHGDQRVSVQQ 89
gi 686735981  53 ----sqksHLPSVVVEANEVN-EESGDLHLPHEELLLLTDGeEEDAEAFFQDQS 101
gi 831240560  54 ----sqksHLPSIVVEASEVNeEESGDLQWPHEELLLLTDGeEEEAEAFFQDEN 103
gi 655882054  54 ----sqkpRLPSIVVETSEVN-EDGAGLQWPCEDLLLLTDG-EEEAEAFFQDQS 101
gi 554790408  53 -----qkpRLPSIVVEASEGSeEDQEDHQWPHEELLVLTDG-EEDAEAFFQDQS 100
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