Conserved Protein Domain Family
LIME1

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pfam15332: LIME1 
Lck-interacting transmembrane adapter 1
LIME1 is a family of eukaryotic transmembrane adaptors. It plays an important role in linking BCR stimulation to B-cell activation and is expressed in primary B cells. LIME localizes to lipid rafts in T cells in response to TCR stimulation, and is phosphorylated by Lck and recruits signalling molecules such as Lck, PI3K, Grb2, Gads, and SHP-2. LIME acts as the transmembrane adaptor linking BCR-induced membrane-proximal signalling to B-cell activation.
Statistics
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PSSM-Id: 317704
View PSSM: pfam15332
Aligned: 11 rows
Threshold Bit Score: 270.183
Threshold Setting Gi: 821458411
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586980210  27 LCTACHr--------KRVQRSRAGPQGCVMPVEVSLLRQHCLCSLSKSDTRLHELHRGPKSCR-----APRPASVDILHP 93
gi 914907845  27 LCTACHr--------TRVPRHRARLQGSMMPVQVSVLRQTRFCSLSRSGTRLQELYRGPHSSIvslqeAPRPASMDLLRP 98
gi 558195435  27 LCAACHr--------KQARRQPAGLQGTMMPAEMSLLRQPPLCILSKSDTRLHELHQGPLHRT-----APRPASMDLLRL 93
gi 958724492  27 LCAACRr--------KQTQRQQARLQGSVMRAEVSLLRRPHLCSLSKSDTRLHELHGGPRGSR-----ALRPASMDFLRP 93
gi 926707188  93 LCTACNraddplaprKQARRQLSRLQGSAMPAEVSLLRRPHHCSLSKSDTRLHELHRSRPCSR-----APRPASMDLLRP 167
gi 157820417  27 LCTACHr--------KRAQRQQTGLQGSLMPVEVPLLRQAHLCSLSKSDTRLHELHRGQRSTI-----APRPASMDLLHP 93
gi 821458411  31 LCTTCHr--------KGKRKQQSSMK---------LVNVTQLRSLSKSDSKLHELNRSPRNSK-----AQRPISIDLLYP 88
gi 831222186  61 qaagqrdaggsgeclavpgpgwgdwgptclscpqALLRQTQLYSLSKSDSRLHELHVGPQGCR-----AQRPVSMD-LHP 134
gi 332858997  27 LCTACRrpedavaprKRARRQRARLQGSATAAEASLLRRTHLCSLSKSDTRLHELHRGPRSSR-----ALRPASMDLLRP 101
gi 281343235   1 -------pdetlaprKRVQRQQARPRGGAMPVEASLLRGHHVCTLSKSDTRLHELHRGPSGCR-----APRPASMDSLRP 68
gi 545541565  69 LCTACHr--------KRAQRQQ--PPGRVMQAEALLLRRHPLCTLSKSDTRLHELHRGPGGCR-----VPRPVSMDVQRP 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586980210  94 RWLEVPRGTSRP---LTAFSHRELPRATP--AATLPSICPE--ATYSNVGLAARPvvwagarltsshaRPGPEA------ 160
gi 914907845  99 HWLEVPRSSTRPqaaPSIFPPQQLPKASP--VSPSPFIGPE--DTYSNIGLAAIP-------------RASLAS------ 155
gi 558195435  94 QCLEVSRDTTRP---PAAFSHRDLPQTSPttAAAQPSTGPE--ATYSNVGLAAIP-------------RASLAA------ 149
gi 958724492  94 QWLEESRGTIRP---PAAFSHRELPQ--------APSISPE--ATYSNVGLASIP-------------RASLAA------ 141
gi 926707188 168 QWLEASRGMTRP---PAPFSHQELP-------LAAPSTGPHgpATYSNVGLATIP-------------RARLAVssgvwa 224
gi 157820417  94 RWLELSRGSTRSqvpNSAFPPRQLPRAPPaaPATPPSTSPE--ATYSNVGLAAIP-------------RASLAA------ 152
gi 821458411  89 RWPGGIRADIQVttvPPVFIHRELPQ--P--PLASDYLALG--STYSNVRLAATPrgppmtergeeqlRTS--------- 153
gi 831222186 135 HWLEVSRDPRRLqaaPSAFPHQEQPQGPP---AATPSAGSL--ATYSNLALVAIP-------------RAGLAA------ 190
gi 332858997 102 HWLEVSRDITGPqaaPSAFPHQELPRALPaaAATAGCAGLE--ATYSNVGLAALP-------------GVSLAA------ 160
gi 281343235  69 QWLEVSRGTSRP---LPAFSLWELPRAMP--AATSPSICPE--ATYSNVGLAAIP-------------RASLAA------ 122
gi 545541565 134 QWLEVSRGTSRP---LVAFSPRE-PPFSP--AAASPSIGPE--ATYSNVGLAAVP-------------RASLAA------ 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586980210 161 ---------------GP---------------------G---------------------VA------------------ 165
gi 914907845 156 ---------------SPv--------------------V---------------------WAgtrltigcarpglgarpl 179
gi 558195435 150 ---------------SPmvwagagltsscagdepearsV---------------------VA------------------ 175
gi 958724492 142 ---------------NPv--------------------V---------------------WAgarltsscarpgpevrpm 165
gi 926707188 225 garltssyarpgpeaRP---------------------V---------------------VA------------------ 244
gi 157820417 153 ---------------SPv--------------------V---------------------WPgrqltisc-----trlgp 171
gi 821458411 154 ---------------EKl--------------------V---------------------MA------------------ 159
gi 831222186 191 ---------------SS---------------------V---------------------AT------------------ 195
gi 332858997 161 ---------------SP---------------------V---------------------VA------------------ 165
gi 281343235 123 ---------------SP---------------------Vvp------------------eVA------------------ 130
gi 545541565 187 ---------------SP---------------------AvwagarltssraspgpeprpeVA------------------ 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586980210 166 --EYACIQKL-EGT--------------DQGPQSLRQWKAEVTPAVQVDILYSRVKKPKKRDLGPA-----TDQLDPKGR 223
gi 914907845 180 vaEYSCIQKL-KGT--------------GQGPQELQQGTAERIPTAQVDILYSRVCKSESRDPGLI-----KNQPDFKGG 239
gi 558195435 176 --EYACIHKL-KGT--------------GRGPQGLDQGKVQGTPATQVDILYSRISKPKRRDAGSA-----LGQPDPKSR 233
gi 958724492 166 vaEYGCIQKL-QGT--------------GPGPQALEQRKAQVIPAAEVDILYSKVNKPKRRSPGPV-----IDQPDPKGR 225
gi 926707188 245 --EYACVQKF-RGT--------------DQGPQGLGQGKVEATPPTQVDILYSRVNKPKRRDPGPA-----TDQPDPKGG 302
gi 157820417 172 gaEYACIQKH-KGT--------------EQGCQESQQ-KAKVTPATQMDVLYSRVCKPKRRDPRPD-----TDQLNLQDG 230
gi 821458411 160 --EYACVRKIkKGTevgssvtgpsdsgpEEKKAQNLEKAAE------VEVLYSKISRLGRKPLEPTgnralCNKMDRDTQ 231
gi 831222186 196 --EYSCVQKL-KIT--------------QRAPQELQQANAEVSPTAQVDILYSRVCKPKRRTxAPT-----TDPPDPKGR 253
gi 332858997 166 --EYARVQKR-KGT--------------HRSPQEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPT-----TDPLDPKGQ 223
gi 281343235 131 --EYACIQKL-KET--------------DQGPQSLGQGKAELTPAVQVDILYSRVRKPKKRDPGPA-----TDQLDPKGR 188
gi 545541565 213 --EYACIRRL-KGA--------------AQGPQGLGQGTAAPTPAVEVDILYSKVRKPKKRDPGTA-----ADQLDPKGS 270
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 586980210 224 GEIPALGSDQAYETL---------PLRGLGMDDGLPDNVYETIQE 259
gi 914907845 240 GSILAPRNDMTCETL---------PLRDLSMDSRPLENVYESIQE 275
gi 558195435 234 VAILTRGRNLDYEAL---------PLRGLST-HSDLENVYESIQE 268
gi 958724492 226 GAILVLGSDRAYEAL---------PLRGRGVDNSLLENVYESIQE 261
gi 926707188 303 GAILALGSDPAYEVL---------PLGGLAMDKSLLENVYESIQE 338
gi 157820417 231 RTILALGNDVKYEAI---------TLRGQDMKQGTLENVYESIKE 266
gi 821458411 232 APLMETTNEQSQSPAinssyrigsPTWGKNTGNGHTENFYESISE 276
gi 831222186 254 GAILVLESDLAYEVL---------PLWGRGMDHRPLENVYESIQE 289
gi 332858997 224 GAILALASDLAYQTL---------PLRALDVDSGPLENVYESIRE 259
gi 281343235 189 GVIPPLGSDQSYETL---------PPRGLGKDDGLLENVYESVQE 224
gi 545541565 271 DAVLAVGSDQSHETL---------PLGGLGKDDGLLENVYQSIQD 306
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