Conserved Protein Domain Family
Auts2

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pfam15336: Auts2 
Autism susceptibility gene 2 protein
Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.
Statistics
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PSSM-Id: 317708
View PSSM: pfam15336
Aligned: 20 rows
Threshold Bit Score: 101.432
Threshold Setting Gi: 572275438
Created: 3-Aug-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768908441   460 AMHVYLAWMILSHQKKVK-LMQAEPHKLDFRSd---------PLARLPGAggl---gplGTIGGgLPPTHELTRPPSLFP 526
gi 637355695   603 AMHVRVAYMILRHQEKMK-LMQGDPHKLDFRNd---------LLAGLPGT---------GVFGG-LPHAQEMARPATLFT 662
gi 612038840   296 AMHVRVAYMILRHQEKMKlm-qGDPHKLDFRNd---------LLPCLPGA-----------YGG-LPPGQELSHPASLFT 353
gi 597792375   566 AMHVRVAWMILRHQEKVK-LMQADPQKLDFRNd---------LLPRLPGPggiggigglGPLGGpLPPTHELSRPGSIFT 635
gi 528496194   551 AMHVRVAWMILRHQEKVK-LMHADPQKLDLRNe---------LLPRLPGPgigg-lgglGPLGGpLGPAHDLTRPGGLFA 619
gi 572275438   591 AMHVRIAWEIYHHQQKQQaEAK---AGSVVNTktellrppghLYAAGPGT---------GLGIG----ASPMAPP--FPT 652
gi 768949026   631 AVHVQIAWQIYHH-QQKMkQMQLDPHKLDMNGkl-------dLFSRPPAP---------GVFPG-FPYPHDLARP--LFS 690
gi 1024958570  592 AVHVQIAWQIYHHQQKMK-QMHLDPHKLDMNGkl-------dLFSRPPAP---------GVFPG-FPYPHDLARP--LFS 651
gi 1020957120  493 AVHVQIAWQIYHHQQKIK-QMQLDPHKLEIGGkl-------dLFSRPPAP---------GVFPG-FHYPQDLARP--LFS 552
gi 733911468   491 gvsdpyrppvrvskkpgkwcavhvqiawqiyhhqqkikqmqldphkleiggkldlfsrppapgvfpgfhypqdlarplFS 570
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768908441   527 ATGPVNP-SSAQFmAPP-TAH-SSFL-PPPAHL----DPYGR-SPPFTPLGALGSGAFGGLGSPTM-AGSVFGHK-DS-P 594
gi 637355695   663 ASGVVHPgSGASF-GPPgTPH-GSFL-SPGPHI----DPFSR-PPSFASLGALSNGAFGGLGSPSFnSSAVFGQK-DS-P 732
gi 612038840   354 ATGAVHP-AANPFtAAP-GPP-TSFL-SPGTHI----DPFGR-PTSFASLAALSNGAFGGLGSPTFnTGAVFAQK-ES-P 422
gi 597792375   636 AAGGVNP-SSTPFiSPS-TPH-SSFL-TPATHL----DPYGR-SPPFPPLGALSSGAFGGLGSPSLsASSVFGHKaES-S 705
gi 528496194   620 ATGGVNP-SSTPFmPPS-TPH-SSFL-TPAAHL----DPYVH-SPHFSSLGALGSGAFGGLGSPTI-AASVFGHKtEP-S 688
gi 572275438   653 NIPPAHP-------APP-PPHpVGFLsTPASHLgtgmSPFGRyPSTFGA----PNPNFPGLSS--------FPPSrEM-P 711
gi 768949026   691 STGSGHP-APSPY-GPA-PHP-SGFL--PPSHLa---DPFSR-SSSFGGLGNLSSSAFGGLGNPSLgSNNMFGTK-EGpG 759
gi 1024958570  652 STGSGHP-AASPY-GPS-PHH-AGFL--PPSHLag-kYPFSR-SSTFGGLSNLSSSAFGGLGNPALgANSVFGPK-EG-P 721
gi 1020957120  553 TTGATHP-ATTPF-GPS-PHH-SSFL--PTNHLa---DPFSR-SSTFSGLGNLGSNAFGGLGSHALtHNNIFTHK-DG-P 620
gi 733911468   571 TTGATHP-ATTPF-GPS-PHH-SSFL--PTNHLa---DPFSR-SSTFSGLGNLGSNAFGGLGSHALtHNNIFTHK-DG-P 638
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768908441   595 ATVVGglpnANH-HDPWNRLHAGPAAFPAGP--SW---AKATD--KRD-------ERDRg------kDGEr--------- 644
gi 637355695   733 GAPPF----PNP-HDTWNRLHRTPPSFPTAP--AW---PKSGTgdGTErg---gpQHDKe------gEKP---------- 783
gi 612038840   423 GAPPAf---ASP-PDPWARLHRGPPAFP-----AW---ARPPEaaRTP-------GSDKe------rPVEr--------- 468
gi 597792375   706 ASAVGg--lSNP-HDPWNRLHVAPPSFPSGP--PW---AKGLE--KRD-------ERDRg------kDLEr--------- 753
gi 528496194   689 ASAVGg--lGNP-HDPWNRLHVPPASFPSGS--SW---AKGPE--KRE---------DRg------kEVEr--------- 734
gi 572275438   712 PLGGL----GSV-HDPWRGLQRASAGFPPTTavSWslkPEPPAidRRAeleererERERe------rEREr--------- 771
gi 768949026   760 GLPTF----GSPhHDTWNRLRRTPPSFPTPP--QW---PKTADteRSSs-------------------aNsherererer 811
gi 1024958570  722 GLPGL----SSPhHDTWNRLHRTPPSFPTPP--QW---PKSADaeRSSsanshdrERERerekekerERDk--------- 783
gi 1020957120  621 NLQNF----NNP-HEPWNRLHRTPPSFPTPP--QW---PKPADseRSSsvtnhdrDRER--------EPEk--------- 673
gi 733911468   639 NLQNF----SNP-HEPWNRLHRTPPSFPTPP--QW---PKPSDseRSSsvtnhdrDRER--------EPEk--------- 691
                          250       260
                   ....*....|....*....|.
gi 768908441   645 ----------rDIPHIKDEKD 655
gi 637355695   784 -----------DGPVIKDEKD 793
gi 612038840   469 ----------rEPSAPKEEKD 479
gi 597792375   754 ----------rEL-HIKDEKD 763
gi 528496194   735 ----------rELTHIKDEKD 745
gi 572275438   772 ----------eR------ERE 776
gi 768949026   812 ererererekrDSSIGKEEKD 832
gi 1024958570  784 ----------rDSSIGKEEKD 794
gi 1020957120  674 ----------rDLSLSKDDRD 684
gi 733911468   692 ----------rDLSLSKDDRD 702
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