Conserved Protein Domain Family
GEMIN8

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pfam15348: GEMIN8 
Gemini of Cajal bodies-associated protein 8
GEMIN8 proteins are found in the nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies themselves. They are also found in the cytoplasm. The family is part of the SMN (survival motor neurone) complex that plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. GEMIN8 binds directly to SMN1 and mediates the interaction of the GEMIN6-GEMIN7 heterodimer.
Statistics
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PSSM-Id: 317719
View PSSM: pfam15348
Aligned: 34 rows
Threshold Bit Score: 148.294
Threshold Setting Gi: 780020646
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063482   13 SWSSHPVYARYWQHYHQAMAWMRSHQSA-------YQKAVESVVTspWYYPATdlAQSPAakggtsPksrskspsasgDa 85
gi 973186834   10 PWYSHPLYARYWSHYQQAAHWQHKHWQA-------YRKALEAAYCvpYRAEgaavarrhs-----------------sgs 65
gi 260831336   54 HWHSNPRYDKYWQHWHSMMGWYQLHRKApaqvqavWQHVMQNGYApmEPCE----------------------------- 104
gi 541044114   14 AWWNGPRFANFWARYEAAAAWIDIHRQA-------VCASHAATFGi---------------------------------- 52
gi 612044206   10 PWYSQRAYARYWQHYNQAMQWMRRHQSA-------YRKAMLSFYNspWYLPALl-PSSRYadwggdDqaaqegrlpstGw 81
gi 1018989918  11 PWYSRPVYARFWQHYSQAMHWMHRHKIA-------YRKAIESFYSlpSHRPEPp-PSGRYadwsgdDlp-------apGw 75
gi 528468249   11 LWFAHDVYSRYWQHYQQAMNWNQKHKRA-------YRSALEAGYFqtLYSMNPsaTMQCYsdwhgnE------------- 70
gi 597732844    9 AWYSHPVYARYWLHYQQAMTWHQRHRQA-------YSKAVQAAYGpaLYHTFPt-TSPRYtdwhseE------------- 67
gi 542254866    9 SWFSSPVYSRYWQHYQQAMAWHQRHRRA-------YRKALEAAYGpcCYQEEGrsDRARYadwssaEsnsed-------- 73
gi 780020646    1 ------------------------------------------------------------------Ypshhh--qdsfHh 12
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063482   86 CRRrSRPG----KPGPQRRSTEKPARFAED-------------------------------NDSESdD---CGI-----V 122
gi 973186834   66 eresagPE----ACPRFPSGGKRGPSASRRaagtkrv-----------------rcsrdgeENSSS-D---GEV-----E 115
gi 260831336  105 ------ARtnhyRRRHHSWDRRSASKDSLSsnakrrkrtkrkkhkkkrnrknaakhsdtdmMDTTS-DagnSEV------ 171
gi 541044114   53 -------------REDDAFNENEENEACTSigevifrasd------------sdewdlcteEEDQS-------------M 94
gi 612044206   82 PSRsPYSR----WSQQPPAHAHSHRMTSKEnqap------------------------steEESDS-D---GEI-----E 124
gi 1018989918  76 PRKsGHLH----WSGPRPDTGRDCQGTTEEdrgs------------------------tteEESES-D---GEI-----E 118
gi 528468249   71 ------------------CLKNSHRDRLKEkreneit-----------------gsdseieEESSD-E---SQL-----E 106
gi 597732844   68 -------------------RKDRTRGRMKRrgrgyaveed------------eevpesteeSESSE-E---SEI-----E 107
gi 542254866   74 --------------------------------------------------------eeggvEESSS-E---SEI-----E 88
gi 780020646   13 HHHhPYKP----HPAASSYRGSKQYVTDQSdvdyng--------------------fsetqQEDDD-E---GQVygeggE 64
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122063482  123 CDLSNMVITDELRQYFAETEQHREELRR-----QHQLD---AARL---------------KD----YVNADHGLYCD--- 172
gi 973186834  116 CDVSNMEITEELRQYFAETERHREERRK-----QQQLE---EEQQ---------------SA----YVPADHDLYRV--- 165
gi 260831336  172 -----LEISPEFREFMAVTARHREERRR-----QREEAartAAME---------------ED----YIEADKLGLPK--- 219
gi 541044114   95 DEEEEVEIDEEMAAFLRQTAEHR-----------KQRD---AERLkennkrgdywmeingED----YILADKIGVEG--- 153
gi 612044206  125 CDLSNMEITEELRQYFAETERHREELKR-----QQQLE---AQHQ---------------DV----YVEADHDLHQT--- 174
gi 1018989918 119 CDLSNMEITEELRQYFAETERHREELRR-----QQQLE---ADSQ---------------DV----YVEADHDLHLP--- 168
gi 528468249  107 CDVSNMDISEELRQYFAQTERHRQELKK-----QQQME---AEQQ---------------DS----YILADQDLHRV--- 156
gi 597732844  108 CNVSKMEISAELRQFFAQTEQHREELKK-----QQQME---AERQ---------------ED----YVLADQDLHRV--- 157
gi 542254866   89 CDVSNMEISEELRQYFAQTERHKEELKK-----QQQME---AEQQ---------------GS----YVPADQDLHSF--- 138
gi 780020646   65 EEEFEVELSEEMRQFFLQSQKHREELKElrlaiNQKEH---AERT---------------KDgdmaHENAEEDESYDdef 126
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122063482  173 ----------K-RgRST-L-PPTERPGERRQAEMK-RLYGASAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKF 234
gi 973186834  166 ----------A-R-RSA-Q-PPRDQPGVRRGIEMK-MLYGEDAAKIQGMETAMQLTFDRNCDLKQPKYWPVIPLKL 226
gi 260831336  220 ----------Y-G-RTTtE-APAQQPGQQRKAEMK-RLYGIRAPVIHGLETAMQMAFDACCDLKQPKLWPTIPLKL 281
gi 541044114  154 ----------AsH-RTT-A-TPNVAAEEQAKHELReKFYGKDANKIAAMEAALQIRYEQYVANTDAQMWPIIPLKI 216
gi 612044206  175 ----------T-G-RSV-Q-PPSERPGERRMVEMK-KLYGDSAAKIQAMETAMQLTFDKNCDKKQPKYWPVIPLKL 235
gi 1018989918 169 ----------T-R-RSV-Q-PPAERPGERRMAEMK-KLYGDSAAKILAMETAMQLNFDKGCDQKQPKYWPVIPLKL 229
gi 528468249  157 ----------S-W-RST-L-PPSERPGERRTAEMK-KLYGKDAAKIQGMETAMQLTFERNCDKKQPKYWPVIPLNL 217
gi 597732844  158 ----------S-W-RSA-Q-APVERPGERRSAEMK-KLYGKDAAKIQGMETAMQLTFDRNCDRKQPKYWPVIPLNL 218
gi 542254866  139 ----------S-LqSSV-A-PPLERPGERRTAEMK-KLYGGDAAKIMAMEAAMQLNFERNCDLKQPKYWPVIPLKL 200
gi 780020646  127 emsftsskkgK-K-KHI-IgAPVEQPGRRRAEEMK-ILYGKDSPAIHGMETAIQMQFDRNCDKKQPSFWPTVPLKM 198
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