Conserved Protein Domain Family
PAXIP1_C

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pfam15364: PAXIP1_C 
PAXIP1-associated-protein-1 C term PTIP binding protein
This protein domain family is the C-terminal domain of PAXIP1-associated-protein-1, which also goes by the name PTIP-associated protein 1. This family of proteins is found in eukaryotes. The function of this protein is to localize at the site of DNA damage and form foci with PTIP at the DNA break point. Furthermore, studies have shown that depletion of PA1 increases cellular sensitivity to ionizing radiation. Proteins in this family are typically between 122 and 254 amino acids in length.
Statistics
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PSSM-Id: 317731
View PSSM: pfam15364
Aligned: 13 rows
Threshold Bit Score: 126.383
Threshold Setting Gi: 390363838
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390363838  547 DWDIPATDDEEEDE---ENqaadgiekkkrkvvkrgyW----------EPPIDVIVDL---YKKLDQDGILELSWKCPGR 610
gi 327280713   60 DWCIPCSDEELDSP---DN------------------W----------MPPPSEIRHL---YELIAEQGTLELQAEILPR 105
gi 557022472   38 DWYVVCSDEEVENP---EN------------------W----------SPSPNEIKRL---YELIVEHGTLELQMELLPR 83
gi 699252125   17 DWHVSGSDGEDASD-----------------------Y----------QPDPTTIVKL---YNLINSGELPPLQTFIHPR 60
gi 360043304    5 NFRLLDDDTQFMDK----------------------------------YPNGLSLVDLlpfYDSISKNEPLKLEWVCPGK 50
gi 260785078    6 DFDIPASDDELAAS---ES------------------WdaehknyvswEPPAADIASL---YEKLEKDGVIELQMKCLPR 61
gi 156394982    7 YWVIENSDDERDEE---LKafk------------gnlT----------GDIPIQILKH---YKQIEQDGVIEIKLEEYRK 58
gi 444725813  155 vWKVECSDEEVELPadgQS------------------W----------MPPPSEILRL---YELLAAHGTLELQAEILPR 203
gi 927152413   58 DWCVPCSDEELDSP---DN------------------W----------MPEPKEIRRL---YELIAEHGTLEIQAEILPR 103
gi 432922707   91 EWEIPYSDEEMEDA---KN------------------W----------MPPPLEIKRL---YELLAKGQMLELNFEPLPR 136
gi 657592416   96 EWELAYSDEEIEDS---KN------------------W----------MPPPAEIKRL---YELLAKGEMLELNFVPLPR 141
gi 597769875   86 DWEIPYSDEEMEDP---KT------------------W----------MPQPQEIKHL---YELLAKGEELELKWVPLPR 131
gi 1031985950  87 EWMIPYSDEEMEEP---QN------------------W----------MPPPAEIKRL---YELLAKGEELELQWVPLPR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390363838  611 RP----PS------------EEGDKEEEKEEMEDV------QDEeameisqeedPTEFDFDMDIe---------lDSSVQ 659
gi 327280713  106 RN----PTpepds--ededkSEGQTEDQEEEEEEK------PHV----------PTEFDFDDEP-----------SSPKS 152
gi 557022472   84 RE----LTpepe-----peeEQSEEEPQEEQEEEK------LPE----------PTEFDFDDEl-----------VTPNP 127
gi 699252125   61 DK----LQtkelq---vkqeSPALLKSESIETKTS------PSE----------PNEFDFDSq------------STASV 105
gi 360043304   51 ID----PNvqrettkirtetNDNPVPKVSESLTSI------VKL-----------KEFDFDESPnqpsipsvplgAAAQN 109
gi 260785078   62 RA----PTpkpee--pdtkeEEKEEEKPEETPSKK------PAV----------PS-FDFDEFSm---------eTTPAK 109
gi 156394982   59 QQkddlPVkqkrkedeedrnADGEIDEKKQNYAND------RSVe---------ASAFDYMDD---------------SD 108
gi 444725813  204 RP----PTpeaqs--eeersD--EEPEAKEEEEEK------PHM----------PTEFDFDDEP-----------MTPKD 248
gi 927152413  104 RN----PTpepds--ededkSDGQSEHQEEEEEEK------PHV----------PTEFDFDDEP-----------ATPKS 150
gi 432922707  137 RP----PTperslsperdeeDEAVKERE------RqdrerkPPS----------PTEFDFDEENm---------qTTPKN 187
gi 657592416  142 RP----PTpertpsperdeeDDAAKERDRLERDRK------PPT----------PTEFDFDEEQm---------qTTPKN 192
gi 597769875  132 RP----PTpprtpsperdgeD--SQEAKEDDSQCK------APS----------PTEFDFDEEQt---------mATPRN 180
gi 1031985950 133 RP----PTpprtpspegdgdD--TQDHTQEQAERK------ALT----------PTEFDFDEEQt---------lATPKN 181
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 390363838  660 KKMTPRRNIGggqA--QGSGKKRVARMDKVLNDIFRHRKIDTS 700
gi 327280713  153 SLIDRRRTPG---S--LAKSQKREARMDKVLSDMKRHKVLEEQ 190
gi 557022472  128 SFMNRRRTPG---S--LVKSQKRKARLDKVLSDMERHKRLEEQ 165
gi 699252125  106 KRFTPKRTPN-------RPQQKKVARMDKVCSNILKYKKLDEE 141
gi 360043304  110 ANLPLRRLAGt--Sr-HPPRQPRVASMDKILNDFFKTRKEPSS 149
gi 260785078  110 TFTPTRRTPGs--RptPRSGQRRVARMDNIMSSIMRHRRQDpd 150
gi 156394982  109 EWQEPKRTPK---H--GRVNKKRVGSLQNVISDLKRFKELDQS 146
gi 444725813  249 SLIDRRRTPG---S--SARSQKREARLDKVLSDMKRHKKLEEQ 286
gi 927152413  151 SLIDRRRTPG---T--VAKSQKREARLDKVLSDMKRHKVLEEQ 188
gi 432922707  188 AFINRRRTPGs--S--GRSTVKREARLDKVLSDMKRHRKIEEH 226
gi 657592416  193 AFINRRRTPGs--S--ARSSVKREARLDKVLSDMQRHRKIEEH 231
gi 597769875  181 SFLSRRRTPGs--S--ARSSVKREARLDKVLSDMKRHRKIEEH 219
gi 1031985950 182 SFLTRRRTPGs--S--ARSTVKREARLDKVLSDMKRHRKIEEQ 220
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