Conserved Protein Domain Family
FAM117

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pfam15388: FAM117 
Protein Family FAM117
This protein family is a domain of unknown function found in eukaryotes. Proteins in this family are typically between 269 and 453 amino acids in length. There are two conserved sequence motifs: RRT and TQT.
Statistics
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PSSM-Id: 317754
View PSSM: pfam15388
Aligned: 26 rows
Threshold Bit Score: 240.343
Threshold Setting Gi: 746837555
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597749147 186 IRRTSSLGAITGPYLTGQWPRDPH--VHYPSCMKDKSTQTPGCWSEETSEGEl-R-STHQRSASWGSADQLKEIAKLRLQ 261
gi 556993368  69 IRRTFSLDAIVVPYLLGQWPCDVD--THY-SCLNEKATQTPSAWLEAQKERS--SaCLHKRSASWGSTDHLREIAKLRQQ 143
gi 542256959 119 MRRTMSLDAIIGPYLQGHWPKEPE--GPSCVPRQDKSTQTPDSWSERCYSRRg-S-SSHKRSASWGSAEHLREIAKLKQQ 194
gi 327275899  56 VRRTSSLDNVLGSYLLGQWPRDAD--GAAIAHMSDKSTQTPVSWHDTGMGR---A-TVHKRSASWSSVDHRREIAKLKQQ 129
gi 597783330  54 IRRTLSLDAILAPYLQGQWPREGErrGQSGHRKNDKFSQ-PSNWRPDKAERS--StGSHKRSASLGNGDHLRDIAKLKQQ 130
gi 156385105 108 LRRTSSLDAISGTYLSGQWPRANEt-SSYGPLVCHKSTQTP-TWDESEIDEP--S-YRPKRSNSWSSADHMRE--KLRQ- 179
gi 733922886 105 VRRTSSLDTIVGSYLLGQWPRDAD--GASASCMNDKATQTPVSWHDAEVGKAs-S-SAHKRSASWGSTDHRREIAKLKQQ 180
gi 821481703  27 VRRTFSLDTILGSYLLGQWPRDAD--GTFTCYTNDKATQTPLSWHELEGEQTg-S-CTHKRSASWGSTDHRKEITKLKQQ 102
gi 532071851  86 VRRTFSLDTILSSYLLGQWPRDAD--GAFTCCTNDKATQTPLSWQEPEGERAs-S-CTHKRSASWGSTDHRKEITKLKQQ 161
gi 47219725   54 MRRTMSLDAIIGPYLQGQWPKEPE-----SSSHKDKSTQTPASWADESHSRKgsS-GSHKRSASWGSAENLREIAKLKQQ 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597749147 262 LQ-RSKQGgSRLSKDgRELLSPLHCciitttSHsTiSTASQapflqspmskpaQMP---LsnITVPKPSiSRVPSSMEGI 337
gi 556993368 144 LQ-RSKLC-GR---E-RERNSPIHG------DH-AlLNTSQvpqp--------------vsvSPVGKLS-PRLHRSLEGL 195
gi 542256959 195 LQqYSKPA-VSGAHD-KDRQRGYPQ------GG-RsLGAAQte--------piPIP---P--APLSTLV-PPLRCSVEGL 251
gi 327275899 130 LQ-RTKLG-AYHSKE-KDQSSPVQG------DH-TvLSLAKalp-------paSFP---A--LATVSVS-PCLHNSSDAI 186
gi 597783330 131 LQ----AA-GPINGI-YVRERH-HH------PM-WvCAQSQp----------vPIP---L--SSLTNLP-STMRRSEERL 180
gi 156385105 180 -Q-RIKQG-SNRSPS-YGRQSPLHG------DH-AiQKATQs----------vAIP---I--PKITRSSeGHQRRSLEEL 233
gi 733922886 181 LQ-RTKLN-GRSGKE-KEKSSPLQG------DH-AvLGSLR------------DSPsgfLssSPVLRLS-PCLHRSLEGL 237
gi 821481703 103 LQ-RTKLS--RNGKE-KERASPIQG------DH-AvRGALR------------ASPpsfPsgSPVLRLS-PCLHRSLEGL 158
gi 532071851 162 LQ-RTKLS--RSGKE-KERSSPLQG------DH-AvRGALR------------ASPpsfPsgSPVLRLS-PCLHRSLEGL 217
gi 47219725  128 Lq-RSKAA-VSGGAD-KDCQQGYPQ------GA-CsLGTTQtr--------piPIP---L--APLSTLV-PPLRCSVEGL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597749147 338 NHELEKVFIKDNGEKEElKALEVPDGRRAPFP---------------------PQQRSSSSRSVDTQTPSV-----PgrS 391
gi 556993368 196 NQELEEMFVREQGDKELfRILDVPDGHRAPVP---------------------SQRCCSNSQSDPFSVSLTl---rR--N 249
gi 542256959 252 NQELEGMFISQSLHP-LqRLLEVPDGHRAPVP---------------------LQSYSSGSQSDPPTTPPP-----S--S 302
gi 327275899 187 NQELEEVFVKEQGDEELlRILDVPDGHRAPVP---------------------LQGATRDSLLLPVEHSSS-----S--C 238
gi 597783330 181 DQELERAFTHQSPI-QLsRLLEIPDGHRAPVP---------------------SLSSNSSSRCESSFTTHP-----T--S 231
gi 156385105 234 NTEIQKLVLRPGDDPAEvKLIEPVDGRKAPIPdilsigspfptvdmhtqtqaeNQDSQESSRSHSASPCYPimagtT--D 311
gi 733922886 238 NQELEEVFVKEHGDEEllrILDVPDGHRAPAP---------------------APRGSGDASLM-LEPS----------S 285
gi 821481703 159 NQELEEVFVKEQGEEEllrILDVPDGHRAPAP---------------------AQGVNSDSSLLPLEP------------ 205
gi 532071851 218 NQELEEVFVKEQGEEEllrILEVPDGHRAPAP---------------------PQNGSCDHSLLLLEP------------ 264
gi 47219725  184 NQELEGMFICQPPHPQh-rLLEVPDGHRAPIP---------------------PQSCSSGSQSDAATT--P--------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597749147 392 ---SSCSS---------LSP------CP--------SPA----CPPGSHDG------------------SP----YSTDE 419
gi 556993368 250 ---SDCSS---------LSPtt--plSP--------HPFsq-eTPEECSSE------------------DT----GSEGM 284
gi 542256959 303 ---SSTSS---------SPCsspnyiCT--------SQPns-dAPPDLHQG------------------STdsgfLSPFS 343
gi 327275899 239 ---SSLSLspspssthrRSP------Ht--------------pARTAAEEH------------------SP----GVIEK 273
gi 597783330 232 ---QSPSS---------SSA------SP--------HSLte-lDTDFSAAA------------------QS----CPSPL 262
gi 156385105 312 ---SKPPSr--------CSS------GE--------GPTmtdsAPTDGSNG------------------IE----NASAD 344
gi 733922886 286 gscSSLSLs--------PSP------SV---------PLrlspHTPVRLVAeelssavde-------------vqldpke 329
gi 821481703 206 -----GNLs--------LSP------SL---------PLas-pQSTGQASRfepqaateeltpnpkekaSS----PPRAV 252
gi 532071851 265 -----GNLa--------SSP------SV---------PLas-pQPSGRASHeehrgaiel-asvpsdkaYS----PGHPA 310
gi 47219725  231 ---QSTp----------SSP------SppltyicslsPSse-gLPPDAHQVsspyss----------------------- 267
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597749147 420 LL------EdrdkdSGSSSPLPKFASSPKPNNSYMFKREPPEGCEKIKVF-EEMTSRQSAAVPLFSCPDKNKVNFIP-TG 491
gi 556993368 285 NE------V-----SDCCCPIPKFSASPKPNHSYLFKREPPEGCERVKVFeEALSPSHGDAV-LTSCPDKNKVHFIP-TG 351
gi 542256959 344 FQ------N-----EADLSPLL-NASSPGPNKSCCFQRKPPEGCERVRVWeEISSPQKPTMALISSCPDPNKVNFTPyGG 411
gi 327275899 274 PLleakakE-----NSSTSPVLAFALSPRPNHTYVFKREPPEGCEKVRAFeEVVPLSPDQP-FQPSCPDKNKVHFNP-TG 346
gi 597783330 263 LS------S-----EADAALL---SCSPRPNKSYCFQREPPEGCERVRVCeENISLYKNQPNLL-SCPDPNKVNFTPyGG 327
gi 156385105 345 ES------T-----IDPPS-SQKYASSPKPNKSYTFAREPPDGAEKVPLYvEDNESFEKPS---FTGPDKTKVKIIFsNG 409
gi 733922886 330 kE------------EGSPSPVLAFASSPRPNHSYMFKREPPEGCEKVRAFeEASS-SPDHT-FQPSCPDKNKVHFNP-TG 394
gi 821481703 253 QVe-----------DDGPSPVLAFASSPRPNHSYVFKREPPEGCEKVRAFeEAPSLSPDLT-FLPSCPDKNKVHFNP-TG 319
gi 532071851 311 FLe-----------DGSPSPVLAFAASPRPNHSYVFKREPPEGCERVRVFeEATSPGPDLA-FLTSCPDKNKVHFNP-TG 377
gi 47219725  268 -----------pseadfSMQ-LLLSSSPGPNKSSCFQREPPEGCERVRVWeETSPLEKPKPAVISSCPDPNKINFTPhGG 335
                        410       420
                 ....*....|....*....|
gi 597749147 492 SAFCPVKLPGSLLQHSASQP 511
gi 556993368 352 SAFCPVTIFKPLLPTMDLIL 371
gi 542256959 412 SAFCPVSLPKPLLPSMDMFF 431
gi 327275899 347 SAFCQFSLVKPLIPSVDFLF 366
gi 597783330 328 SAFCPVSLLKPLLPSVDFLF 347
gi 156385105 410 SAFSAL----PSIPKMAITP 425
gi 733922886 395 SAFCPVSLVKPLFPNVGFLF 414
gi 821481703 320 SAFCPVSLVKPLFPSMGFLF 339
gi 532071851 378 SAFCPVSLMKPLFPGMGFIF 397
gi 47219725  336 SAFCPVSLLKPLLPSVDl-- 353
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