Conserved Protein Domain Family
Joubert

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pfam15392: Joubert 
Joubert syndrome-associated
This family of proteins is domain of unknown function, which is found in eukaryotes. However, mutations in the gene lead to Joubert's Syndrome, indicating that the protein that the gene encodes for is vital for correct ciliogenesis.
Statistics
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PSSM-Id: 317758
View PSSM: pfam15392
Aligned: 19 rows
Threshold Bit Score: 253.859
Threshold Setting Gi: 0
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403314398  2901 TDIADIIGDLITKSGVSSHELGLTECQARSI--SRIQRPP---DRGPRRTAEERREIKAWMRRKQKERMSEYLGQLAERR 2975
10_pfamImport    8 TDIADIIDDLITKSGVSSEELGLTKKQARNI--SRIQQSS---GRCPQRTEEERREIKIWMKRKRKERMAEYLNQLAEKR 82
13_pfamImport    8 TDIADIIDDLITNCGVSSKELGLTEQQAKSI--SRIPHSS---GRCPQRTEKERREIQVW--------MADYLNQLAEKR 74
11_pfamImport    8 TDIVDIIDDLITKDGVSSEELGLTE-QAKTI--SRIQHTS---GRHPQ-------EICIWMKKK-KERMAEYLHQLAEKR 73
12_pfamImport    6 TDVADIIGDLITESGVSREELGLTEHQAMKI--SRIHSTPk--KRKSQRTEKEKREIRAWMKRKRKERMAEYLAQLAQKR 81
6_pfamImport     7 TDVADIINDLITESGISSEELGLTEYQAKKL--SRIHSTPk--RKKSQRTEKEKREIRAWMKKKRKERMAEYLAQLAVKR 82
7_pfamImport     8 TDVADIIHDLVKDGGISAHDLGLTENQARKItsTRI-------TRQPPRTEKEKKEIRAWMKRKQKERMVEYLGKLAEQR 80
16_pfamImport    8 SDVTDIVNDRVVESSTSLLELDLLQNQFTST--LRVLDSA---SGHSQRTEKERKEIQTWMKRKQKERMREYLKKLDEQR 82
1_pfamImport     8 SDVTDIIRNLVTEGGISPMELGFPKTQAKKF--SRY----------SQKTEKEKKEIRAWMKRKQKERMREYMKKVDEQR 75
5_pfamImport     8 SDIADILSDLM-KGGVSASELGLTETQATSL--SRVRPQSapsRPGSKRTEEERLELQNWMRKKQRERLTVHKRQLEELR 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403314398  2976 GRERNPFCPTSSPFY-MTSRQIRQRQKMKREKDRLQL-SKHYSQRLSQAYSLMNELLSDSAHITAPAE---NPLPPGP-- 3048
10_pfamImport   83 GQERDPFCPRNSPFY-MTSRQIRQRQKMKHEKDRLLL-SNHYSQRISEAYHLMNELLSDSVQLTAPAD---QPLPNRPpt 157
13_pfamImport   75 RQEHNPFCPRRNPFY-MTSREIRMRQKMKHEKDRLLL-SNHYSQRLSQAYSLMNELLAESAQLPATAQ---KPSPNKRst 149
11_pfamImport   74 GQEQASFCPRNNPFY-TISREIGPRQKVKYEKDRLLL-SDHYSRQISQAYSL----------LPTTAQtqmQQLPNKRrt 141
12_pfamImport   82 EQEYEPFQPQRHPLC-MTSKEIRLCQRMKNEKDRLQL-SEHYDRRVAQAYSLMNELLFESAQVPRRCL---KKPPGSPak 156
6_pfamImport    83 EQEHEPFQSPRKQLC-MTSKEIRMCQKMKTEKDRLQL-SEHYHRRVAQAYNLMNELLVESAQTTGISP---TKPPCGPak 157
7_pfamImport    81 AQEHNPFHSRRSANA-MTSREIRLSQKLKVEKDKRMLqSKHRSHRVSEAVTLMNELLSETVRLPTDES---RPLSGTPal 156
16_pfamImport   83 QKEHHPFNLGKNTHHhPTSKDIRIFQKKKEEKDKALL-SEHHRIRISQALSLMNEMLSETVPSPASDH---RALSSTRsl 158
1_pfamImport    76 QKEHNPFNFKKYTHCrLTSKDIQLLKKKKEEKDKRLY-AEHHRMRVSQALSLMNEMLSESVMLPASEH---RPWSRARs- 150
5_pfamImport    85 AMEHRPYQPARDANTsVSSRTILRHQRLKDERDKSLL-SEHHGHRVSQALGLMQEMLSEAQHVPAVPS---SPSASRLqk 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403314398  3049 -------YR-RQRGSSpkrenahg--------qslpvnrpGGD-----RHIsrsSHLckgqprgs--------------- 3092
10_pfamImport  158 a----qhYR-QQHCSSprrenphg--------qnflinrpGRG-----RHIsrsSRLqkgkpleqsk------------- 206
13_pfamImport  150 a----rhCG-QQRCPSprrenqhg---------hnflsrpGKV-----RCVsksSYThtgkplgqpegsswprgtatfti 210
11_pfamImport  142 a----qvSK-QQRFPCpnrenqhg--------nnfpinrrGKV-----SCIpksSYTqkgkpfvqpqd------------ 191
12_pfamImport  157 s----arIS-MVFCPGprskdrni--------ntlspnrnSKV-----RFAskpTYIhgrtplsqhqhpsqrnrsknvtc 218
6_pfamImport   158 s----frIStRQRHLPprgvdhni--------htsspgrnTKV-----RFApkpTYIharspprqhqhsfprnnttttkv 220
7_pfamImport   157 a----rgLR-RQLLPPprgdnphg--------htlltsqaEKI-----KFAskpAYAqkrsnlsrgpqnsiwstgaakfa 218
16_pfamImport  159 nk-ptqeLS-YNECPNpfhsashfafclsrrghldspvlaERS-----RIAakpGFGqkkgnvyfpgntcmilqkstsr- 230
1_pfamImport   151 ----------PQECRKnhivstkgg-------hpnnrvtsERS-----RTAvrpRFGqkghhftpalg------------ 196
5_pfamImport   161 qrsspggHS-AATRSSpashvg-------------rhrplsRTvvpreRPLstpSRLqsrgtwpppnikpwpllshgte- 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403314398  3093 ---------------------------------sqlrgsqpP---------CQSQ--------KPLRSRGAAGVGPPVQQ 3122
10_pfamImport  207 -------------------------------gssrrqgsntS---------CQSL--------LHTNSR---GVAPPKKQ 235
13_pfamImport  211 hs--------------raagakaavrkavqspgtswkasnaP---------GCSL--------QHAKNHRHTGLTSVSQE 259
11_pfamImport  192 -------------------------------spclqkgsdaP---------YCSL--------QHTKNYGT--------K 215
12_pfamImport  219 isitgkaatsvkkttevtrkparnvscfsdlssqvfgtsglP---------------------SYLGMCRTE-------- 269
6_pfamImport   221 kk---------------alvatclfktvvqqpmqiqrnfgyP---------CPRA--------RSIKDSKTSSTTTNTE- 267
7_pfamImport   219 vqk-------------qtrdakatvrnaprspvtsrqtssyP---------TPNV--------RYLSSPGDP--VGSQSE 266
16_pfamImport  231 --------------------------------rqlrnatncpvdsrhyftaecRV--------SRRSTQKPPQVTTAVQT 270
1_pfamImport   197 ----------------------------------------------------saqskaaeyrmSRVSEQKYPAVSTAFET 224
5_pfamImport   226 --------------------tfvkqrspsdpksrarsapsyPvhlkfgepsLPYLllcywqgcNCQGCRGCQKGRSQPDH 285
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 403314398  3123 ACREDEREEMVVSPWTLPSEIHRILHGRPESLLQ-D-----MSPADEEEPe----PPLLAGGMDSVSESTGSILSKLDWK 3192
10_pfamImport  236 VCIEYEREDTVVSPWTLPSEIHRILHDRPKTLLQ-D-----ISPAEEEEPe----SSVLVAGMDSVSESTGSILSKLDWR 305
13_pfamImport  260 MGIEYEREEMVVSPWALPEEIHKILLESHSSLLQ-E-----LPPTEENFE-----PPFEVGGMDNISESTGSILSKLDWN 328
11_pfamImport  216 RCVEYEREETVLSPWTLPSEIHKILHDSHDSLLQ-S-----LSPPEEEK------PSAGVSGMDSRSEGIGSILSKLDWN 283
12_pfamImport  270 ---EYEREHDKMSSWTMADHADRILCRGPWSSLE-D-----FSPAEDEK------FSVSINGLTSGSESTSSILSKIDWR 334
6_pfamImport   268 ---EYGRQHSLANSWALPEEIDKILSRSPNSSLE-D-----ISPPEDEG------FPISINGLDSGSESTGSILSKIDWR 332
7_pfamImport   267 ADVAYERERDVVSPWTVPPEIHRILHDNHDPLFEgSegrppLPKTGLESPhn--gSRLSVNGLDTISESTESILSKLDWT 344
16_pfamImport  271 EGVDLDTDRDVVSPWTVPDDIQRILQETHDSMFQ-L-----LFPPQASAAhslsfSPLGSTNTDSVSESTGSILSKLDWN 344
1_pfamImport   225 EGFDHETGRDVESPWTVPDDIQRLLEDSHDTLFQ-D-------------SaplsfSPVVNHETDRISESTGSILSRLDWN 290
5_pfamImport   286 QDPEFEMERDVVSPWELPEEISNIL-KRSSTLSQ-------IFPGSLNGDg----SSRNLSKVDGLSVSTSSLLSKLDWN 353
                          410
                   ....*....|...
gi 403314398  3193 AVEDMVASVEDKN 3205
10_pfamImport  306 AIEDMVADVEDKN 318
13_pfamImport  329 AIEDMVAGVEDRS 341
11_pfamImport  284 AIEDMVARVDDKH 296
12_pfamImport  335 AVDNMVAMVK--- 344
6_pfamImport   333 AVDDMVASVENR- 344
7_pfamImport   345 AVDAMVASIEDK- 356
16_pfamImport  345 AVEAMIADVEDKN 357
1_pfamImport   291 AIEAMIADVED-- 301
5_pfamImport   354 AIEDMVAGVDETY 366
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