Conserved Protein Domain Family
NTS

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pfam15447: NTS 
N-terminal segments of PfEMP1
This family, the N-terminal segment, is the most variable part of the variant surface antigen family of Plasmodium falciparum, the erythrocyte membrane protein-1 (PfEMP1) proteins. PfEMP1 is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. A structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1alpha1), shows this region is directly implicated in rosetting. NTS, previously thought to be a structurally independent component of PfEMP1, forms an integral part of the DBL1alpha domain that is found to be the important heparin-binding site. This family is closely associated with PFEMP, pfam03011, and Duffy_binding, pfam05424.
Statistics
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PSSM-Id: 317801
View PSSM: pfam15447
Aligned: 58 rows
Threshold Bit Score: 45.4488
Threshold Setting Gi: 74861998
Created: 6-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 74861888     21 SAKHLLDSIGKKVHDQVKNGadgtgasgdAKNYIDDLKGDLQKAP 65
gi 74863067     20 SARNVLENVARLIKAKATKD---------VKRHRNVLKGNLRNAK 55
gi 74863465     20 SARNVLEGFAKDIKRDVSNN---------AKRHGKVLKGNLRDAK 55
gi 74814185     22 SARNILEGYAESIKEQASKD---------AKIHGHHLKGDLAKAV 57
gi 74843065     23 SARGVLEEIGKKIKDKTEKE----------SKHVRQLKGKLSNAK 57
gi 74866726     14 SARNVLENIANEIKVKRENE----------RKYNDKLKGSLWEAR 48
gi 74861998     14 slRDVLENIGSGIKDKRKNQ----------SKYTDKLKGILTKAK 48
gi 74861886     21 SARNVLENIGIEIYNEEKKK---------VNGYTSQLRGDLSRAR 56
gi 1035522639   24 SPRNVLERYGEGIMIKEKDE---------ARIYENSLKGQLKQAK 59
gi 583227570    22 SARNVLEKIGRHIKDEINKN----------SNHTNKLKGTLSNAQ 56
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