Conserved Protein Domain Family
LAMTOR

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pfam15454: LAMTOR 
Late endosomal/lysosomal adaptor and MAPK and MTOR activator
LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localize to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.
Statistics
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PSSM-Id: 317807
View PSSM: pfam15454
Aligned: 48 rows
Threshold Bit Score: 39.1697
Threshold Setting Gi: 74586747
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74586747   19 ETSSLLRHQQQHNQ------Qy----LSDYLQEEQILKQQQRQQELAGIVNELNDNLIDVtSFLSGNNNNNNNNNAS 85
gi 121699549  19 ESSRLLDDDIYQSGygy-gaLn----HANQLTNPDPENIKREREALEAICQRTSDSVIDIwSLQPQPHLQPRATLHg 90
gi 296419122  17 EHQRLLAAPNDHLHshs-ytNgnfanSSHHHSIPDPQALLHEREYLDRLVAQTSENLIDIfapptlthsnstatpns 92
gi 189201147  18 DTSHLLGDQYQPNYg----tSs----SNHNVPQPDPEELRRQRENLERICAETNEQLIPV----SQPSALPEVSEQP 82
gi 684169498  19 DRTRLLYDDYPSSHgygtwaTs----NIPSQNVMSQEEVQREQEALDNITRWASDQIVEIfPHQHRNLAMSAVSSQF 91
gi 557727866  19 ESARLLDDELYQPGygy-gaLn----QAHHLNQPDPEDLKREREALEAICQRTSDTVVDIwALQPQPHLQPRATLPS 90
gi 953382261  45 ESSRLLDEDPYQAGygy-gaLh----QAHQASQPDSEYVRREREALESICQRTSDSVIDIwSIQPQPHLRPQATLHt 116
gi 952554769  19 ESSRLLDDDIYQSGygy-gaLn----HANQINNPDPENIKREREALEAICQRTSESVIDIwSLQPQPHLQPRATLHg 90
gi 325096150  19 ESSRLLDDDLYQSGygy-gaVg----SVHR-QGPDPEYLKREREVLEAICQRTSDSVIDIwAIQSSQ--LPGHTSSS 87
gi 347833717  21 EDQRLLFENDAHSHhyg-sfGn----QDSNAIQADPQEVQRETEALQKVVAQTSNHLVDIfAMVPQNVPRAPVTMYN 92
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