Conserved Protein Domain Family
PCNP

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pfam15473: PCNP 
PEST, proteolytic signal-containing nuclear protein family
PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.
Statistics
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PSSM-Id: 317824
View PSSM: pfam15473
Aligned: 12 rows
Threshold Bit Score: 149.983
Threshold Setting Gi: 110761813
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957095   54 QLQKHNP-LrplpGGRKDSGSSSDDSGDDDNGSQSKT---APPKPSVMPKIGFSfqKPAANAKtsstlstsfnlqkaKPM 129
gi 573903049   25 VKTKTVS-S----SNGGGSNTRSADKRSAEEAAGDSM---VQPAPPKVSKIGLS--SQALKKP--------------API 80
gi 512820682   44 VNTKNVS-Ssn-gGESSSRS---AEKRAAEDSK-------NAPHPFKVSKIGFAigNQNLKKS--------------QPI 97
gi 992179792   25 AKSNTVS-Sst-gPGGG------LGKRPAEGSSTAGDqrrKQAVPFKISKPSISttSPILKKP--------------API 82
gi 170040303   52 AQLRKAAeSqr-kYDHRRSSSSSGSSSSDGSDNEGPV---APPAPPVISKVGFSfqKPPSAKPtstgf-----qlqqKPS 122
gi 432851993   24 VKTKPVS-Cst-vGGDGAAYKRTSQHLSAEEEDESSE---DPPAPRKVSKLGFSmsSQAATKS--------------NAI 84
gi 47230603    24 VKTKPIS-Cst-vGGKGTAFKRTSQHLAPEDDDEDEAs-qIPPAHCKISKIGLKmsSQMGKKS--------------NPI 86
gi 1031985124  25 VKTKTVS-S-------SKASGDSLRKRPAREIDPEDEs-kSTSAPPKMFKSGFSm---TAKKP--------------MAI 78
gi 585182923   27 eareTAA-SwsrrSNGGESSSRSAEKRSAEEEAAD-----LPTKPTKISKFGFAigSQTTKKA--------------SAI 86
gi 126325622   31 VKTKTVS-S----SNGGENSSRSAEKRSAEEEAEDFS---SKPVPAKIAKFGFAigSQTAKKA--------------PVI 88
gi 110761813   15 SVYRAED-SrgddRGRDRSPLRSDDRCEEANYNQSDA---------KKQKLAFGfgKKSGTEQk-------------KGI 71
gi 357613259   44 SGHRGSP-Srp-gRSRERNLENADKRRYSESWEESDEevpAPPPPPRISKISIDfsKPK------------------API 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121957095  130 AIQMK-LGt--APKKETPKL--LKPVANAFAGSD-SDEEPEEMPAECRMRMRNIGRDTPTSSGPNSFGKTKHGFCDSKKI 203
gi 573903049   81 SIKLG-AS---KPKESAPVLpaKKPALAAVFNED-EDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDHQKL 155
gi 512820682   98 SIKLG-AS---KPKEVAPAVvkKKTAVASVFNDD-DDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDSQKL 172
gi 992179792   83 SIKLG-AS---KPKEAAPPPavKKP--ASVFNEDsDDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKQGFSDHQKL 156
gi 170040303  123 AVQLKlAS---GPKKEQPKL--LKPTANA-FADD-SDDEPEEMPAECRMRMRNIGRETPTSSGPNSFGKTKHGFCDSKKM 195
gi 432851993   85 SIKLG-AT---KPKEPVPSLppKKPALASVFNDS-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSDHQKL 159
gi 47230603    87 SIKLG-ATvsvKPKEPVPSVppKKPGLASVFNED-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKHGFSDNQRL 164
gi 1031985124  79 SIKLG-AN---KPKEPPPAIppKKSGLASVFNED-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSDHQKL 153
gi 585182923   87 SIKLG-SS---KPKETVATLapKTLSVAAAFNED-EDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKL 161
gi 126325622   89 SIKLG-AS---KPKETVPTLapKTLSVAAVFNED-DDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKL 163
gi 110761813   72 QIKLG-STs--KPTVKATPI--QRPTVASVFNAD-EEDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDSKKI 145
gi 357613259  104 KMTLG-ATs--KPA--------PKPTVASVFNAD-DDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDAKKV 171
                         170
                  ....*....|
gi 121957095  204 FEKKLNTMTD 213
gi 573903049  156 WERKLKTHTD 165
gi 512820682  173 WERNMKAQLD 182
gi 992179792  157 WERKLKAQTD 166
gi 170040303  196 LEKKLNSLHD 205
gi 432851993  160 WERKIKAQgd 169
gi 47230603   165 WERKIKTQ-- 172
gi 1031985124 154 WERKLKSHTD 163
gi 585182923  162 WERNIKSHLG 171
gi 126325622  164 WERNIKSHLG 173
gi 110761813  146 FEKTLKKAME 155
gi 357613259  172 FEKNLKQALE 181
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