Conserved Protein Domain Family
CPG4

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pfam15481: CPG4 
Chondroitin proteoglycan 4
CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification. The family is rich in conserved cysteines.
Statistics
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PSSM-Id: 317832
View PSSM: pfam15481
Aligned: 18 rows
Threshold Bit Score: 75.8746
Threshold Setting Gi: 393909581
Created: 11-Apr-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 306526213 132 ECPRDCSNDLREALGIVLQDMSHv--ERYHRICEKYSNASTCVNEd-GRCdkdDRGMFEMMTSGLHYMCVEQELAFNATI 208
gi 74962577   59 SCLRRCMPALDNIGALFDAAKNP---ETMKAMCRDMTEASKCATA--AGC---DKIFIGAISNAFQFVCMDNLEKVSSQI 130
gi 74996280   25 ECLSKCLTPLAKLQ-----RSFSyvfNNFEKVCDLLEDGAFCA----RKCtqeDQTKFYQYTTFYRIHCIDYEEDIQEHL 95
gi 312068974  95 DCLQVCLDEVASMLEQPFAGQRSv--DEVGNICSHFDIFQRCLHHn-TTCk--D-ALLDVTTTVIDHLCTFNKDAFGDMF 168
gi 541048760  50 KCLFPCVKDLVGAGVNAFDARNIi--TKTEIVCKEYQKATACV-Ke-SGCk--NTEVYDIATKGIHSTCVEKLPLMPMVA 123
gi 541045377  59 ECARECLTSVKGNVNDVFYGSDRflvESARRMCSELDSIKSCFATk-RSCe---GGFLDITMIALNQVCNGHKDALVSFI 134
gi 802712292 104 pCLQKCMPTLSKFLDSLDTKHSLrdtKDTVALCRQLESIEECAAT--THC---DSTLLDLATKTYKFACVDKIESLGDSL 178
gi 802710632  29 pCLSECIQPLAKMERSF---AFIf--NNFEKVCDSLERGAHCVMKc-GGe---DAQKFHQLTSFYRLYCIDYEEDLEPHV 99
gi 541049015  26 pCLRRCLKPIVDFER---TYAYQf--KNFEKVCDTLEAQAHCS----RKCdlaDQKAFYHYTTFYRLHCVDFQEELEEHM 96
gi 541048058  46 DCLDECATPLVIAVYDMVAYGNSq--THFGDLCIEYSSALTCFEKnaEQCr-aNIRLFKLITSGLDIACDSDRSVFDNAF 122
                         90       100
                 ....*....|....*....|
gi 306526213 209 KCIDDEAGLVQSECDAQCQT 228
gi 74962577  131 ACIQENAGDLQQECESECAV 150
gi 74996280   96 TCIAKAAEDADLVCKDKCKQ 115
gi 312068974 169 PCLYGHSAVIYFTCDNQCRM 188
gi 541048760 124 PCLKKHAEKALLGCDKSCGL 143
gi 541045377 135 PCVRNQALRIQSICESQCKL 154
gi 802712292 179 KCAQDAFSTARVDCETGCIV 198
gi 802710632 100 SCLARASQGSDKECKRRCAM 119
gi 541049015  97 ECLTEVAPQIDNKCRSQCIT 116
gi 541048058 123 ACVDVFRDKPLSECERSCHl 142
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