Conserved Protein Domain Family
DUF4641

?
pfam15483: DUF4641 
Domain of unknown function (DUF4641)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.
Statistics
?
PSSM-Id: 317834
View PSSM: pfam15483
Aligned: 19 rows
Threshold Bit Score: 464.227
Threshold Setting Gi: 675767761
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087     79 EERVGSPMDEKVV-GLD--FLSQPSVETTATGQQVTnletkgAREHPS------PESVCAETEA-------GSIRRAPQA 142
gi 532114955   568 AGRPGSPADEKGD-ALD--FVP-VAVESEAVVQQPMgpeprgAHRYPS------PESFATELSGvwvdaeaGPGGRAALA 637
gi 514463358    92 EGRPGSPADEEEDtALD--FVPHLNIECASMVQQMSnlevqgTRRYPSqslalsSDSHASRVSAmwvdtesGPSQRTVLV 169
gi 1046908755  102 ECQTTSPIDQEEV-DLD--FLPQLSNEAMTIMRELTnlqtrkVCRYPS------PQTYAAELAAlwenideG-SNRRALS 171
gi 223468697    79 EERVGSPMDEKVV-GLD--FLSQPSVETTATGQQVTnletkgAREHPS------PESVCAETe-------aGSIRRAPQA 142
gi 1040235727  211 QAQPSIPASNEEG-AVG--FTAQFAESYAAIVQPLShmgagaLRKSPG------IGRSAAEAAAisapveaGPSGRGPLs 281
gi 655876419    97 EARPKSPTTDRQG-AVG--PAVQFAEACAAILEPLSvsmargL---PG------VGRGATEAAAawapvkaSISGRGGLG 164
gi 672032419   102 ECQTTSPIDQEEV-DLD--FLPQLSNEAMTIMRELTnlqtrkVCRYPS------PQTYAAELAAlwenideGS-NRRALS 171
gi 344257394   102 AGPTSSPVGQEEGgEVSgyFLPQLSIEAMTIMRELTdlqarkFCRYPS------PQSCAAELTAlwssigeGS-NRGAEP 174
gi 672087813    80 EGRPGTPVDDRGD-SLD--FVQHLAVEGTSFGQHLAnreawgVHRHPS------PQTCAAEPFSiwgdsdaSMIRRGTRP 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087    143 --SEEAKFA-ASAGtF-FPKGLEQSRSWVTPR-KSTTSR-MVIGENVHHPT--------SEPEPLDELNEVQMMRVTICL 208
gi 532114955   638 psCVEAPQA-SAAP-LsHPSGPEGSRAWGKPK-RGTKSR-MVGSGEAQQPS--------SDPESSDELSEIQLMRVSICP 705
gi 514463358   170 psCVEGQWD-SGAP-L-HTSGHEGGQPWRGLK-SSTKSR-MTVSGAARRPSsd----sdPESKSSDEFNEIQPMRVNISR 240
gi 1046908755  172 lsSVKGKQA-FEGA-P-YPRGLGRGRAWVTPR-RGTISR-MVSSEVVQYPS--------SNTVSSDELSDTQVRKVTTCL 238
gi 223468697   143 --SEEAKFAaSAGT-F-FPKGLEQSRSWVTPR-KSTTSR-MVIGENVHHPT--------SEPEPLDELNEVQMMRVTICL 208
gi 1040235727  282 --CEESLQA-CASS-H-HMSAPREGRAQEHSK-KRDGNHnMSGSTSVQSACeegavglpSDSESSDEQEEIQPMRVSIQF 355
gi 655876419   165 lsCAESLQR-SAAP-R-PVSAFRKGRDQGHSKtRSARRR-LIFTTDEQRTGtkgwlqlpSDSESSDEFWDVQPLRVSPRL 240
gi 672032419   172 lsSVKGKQA-FEGA-P-YPRGLGRGRAWVTPR-RGTISR-MVSSEVVQYPS--------SNTVSSDELSDTQVRKVTTCL 238
gi 344257394   175 vsSGEGKQV-STGS-L-YPRGLGRSRAWVTSR-RGTTSK-MVRSEAVQRST--------SKP-ASDESSDSQTMKVTICL 240
gi 672087813   151 ltSTEGKQF-TASQ-L-HPRALGRGRAWMTPR-RSATSR-MITSDDAQYPS--------SDPESSDEFSEIQMMRVTICL 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087    209 KDgnhGN---QAKNSGPAETGDLARHSNVQTRDSFMRMPSSLLVSTTRGLTSGVERQASKEPEPFSSKKKQGTLWGKGGS 285
gi 532114955   706 KG---GG---QARSCSPREPGDPARRSSVRGRENFLHMPGPLPTPAPRGLPSGMDKQASAELEAGSSKKTQSMLWGKGGS 779
gi 514463358   241 KG---KG---QARSSFPKEPADAARHLNIRAQASVPHLRGSVMTFAPRRLTSAMGKQPSGELDASSSKKMQNVVWAKGEG 314
gi 1046908755  239 KE---GD---QARSSGLTELDNIGKHTTVHSRGNFVHVPPSVLSSATWGLSSGMERQASAELESSLFKKKPNMGRGKEGS 312
gi 223468697   209 KD---GNhgnQAKNSGPAETGDLARHSNVQTRDSFMRMPSSLLVSTTRGLTSGVERQASKEPEPFSSKKKQGTLWGKGGS 285
gi 1040235727  356 KR---GG---QAKGSSMEVPGQNPRTVTAHCREKFPHTSGPLLTSAPRHLNWAVERQAVGEPGPS-SKKMQSVLSGRGVG 428
gi 655876419   241 ER---RD---RTKDHSSEEPPESPIASTSHGGENFPHISVPFLTSTLQGLTKAMEMQGMGELGPSSSKKVFSGLPGKRGG 314
gi 672032419   239 KE---GD---QARSSGLTELDNIGKHTTVHSRGNFVHVPPSVLSSATWGLSSGMERQASAELESSLFKKKPNMGRGKEGS 312
gi 344257394   241 KE---GN---QAKSSGRTELEDSGKHTNVQGRGRFVHVPPSVLSSATRRFSAGLEKPVSGEPEGSLCKKRQSMVWGKEGS 314
gi 672087813   218 KE---GN---QPKSTGLTELEDPARHTNVHGRENFVHVPSTLLATTPRGLSSAIEKQASGELESSLSKKKQSMVWGKEGS 291
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087    286 KSSYPE-----------Aa----------------------AGIGALPKASPRKKMAQKKKPLWDASAVTLGRAFHQWGQ 332
gi 532114955   780 ----RS-----------Ssas------------------aaAATGDLPRATPRKKAIQEKKSLGGGSRVTLGRAFPSWGQ 826
gi 514463358   315 RPSYPG-----------As----------------------AIAGVLPRATMRKKEAQEKKSLGSGSRVILGRAFPSWGQ 361
gi 1046908755  313 RSSHQGataaaattsaaApgs------------------psAASGALHKTSPKKKQVQEKNSSLDVSRGPQGRNLSPWGQ 374
gi 223468697   286 KSSYPE-----------Aa----------------------AGIGALPKASPRKKMAQKKKPLWDASAVTLGRAFHQWGQ 332
gi 1040235727  429 RPSHIS-----------Vtaaaaaaaat----ttttttttaTGAGGLLLGTPRRKPLQEKRSLGVASEVVLGITFAPWGH 493
gi 655876419   315 SPTHPG-----------Vp---------------------aAPAGSLPQATSRKKEAKEKKPLVVCPEFVLGSAFAPWGQ 362
gi 672032419   313 RSSHQG-----------Ataaaatts-------aaapgspsAASGALHKTSPKKKQVQEKNSSLDVSRGPQGRNLSPWGQ 374
gi 344257394   315 RPGYPG-----------Asaasvstaa-----ansaaapapVASGALPKTNTRKKTAQEKKSLSDASRGPLGRTFPPWGQ 378
gi 672087813   292 RPSHQG-----------AtaaaaatisasatastaapapvaVASGGFPKTSPRKKPPSEKPSQWDASRGPVGRTFPPWGQ 360
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087    333 RLKSAPAEPATFPPISGVGLPGRSNKcsllplrPKQCKNLYTGKRSGAKKTKELQLVAKEDTDSTRDPSSQVQ-----FP 407
gi 532114955   827 RLKVTPLEPATFPPISGVPLLGRSKRhsllplgPKQSKHGATGKRSVAKKTRESQPVTSEDNDPSRDIVPQVQ-----LP 901
gi 514463358   362 RFRAAPLEPSTFPPISGVPLLGKSKGfsllpsgSKSSKQGATGKRSSARRARESQPVAGEDKGPNGDPILQAQ-----LP 436
gi 1046908755  375 RLKSAPVGLATLPPISGVALLGKASKcsl-psgPKECKPFCTGKKFMVKKSRETQAGPKEDNNSPRDPGLQAQifvceVP 453
gi 223468697   333 RLKSAPAEPATFPPISGVGLPGRSNKcsllplrPKQCKNLYTGKRSGAKKTKELQLVAKEDTDSTRDPSSQVQ-----FP 407
gi 1040235727  494 RQSATPVEPAVLPPVSGISLLEKPSTssplpwgSKQSKQGGAGKKPGAKSK--SQTVAGRDHGPYRDPM--AQ-----LP 564
gi 655876419   363 RASAAPGYPVTFPKIPGISLLEEPDTsfslpwvHKQSQQGDTGKDSAARRK--SQPVAA-DRGPDRDPDSGAQ-----FP 434
gi 672032419   375 RLKSAPVGLATLPPISGVALLGKASKcsl-psgPKECKPFCTGKKFMVKKSRETQAGPKEDNNSPRDPGLQAQifvceVP 453
gi 344257394   379 RLKSAPVEPATLPPISGVALIGKTSKnsl-psgPKDCKPFCTGKRSMARKTKESQPGAKEDDDQTRNPGLQAQ-----LP 452
gi 672087813   361 RLKSAPVEPATFPPISGVALLGKASKcsl-psgPKECKPFCTGKKFMVKKSRETQAGPKEDNNSPRDPGLQAQifvceVP 439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81905087    408 THRAEPPCQSVHQ-EFNSGDINARSLQDAGNSQSSALNQRGIMSKKSV---LSGDQEEPVGLPAP-DsEILQLP-GTQGC 481
gi 532114955   902 VHRPGTPCLCMHRgEFISGDPNPRVLQPPGSSQPLDLSQGGL-----A---PSGEQDPPVQTPVL-E-RQQQPP-GVQGC 970
gi 514463358   437 THRPGPRCLNMHHgEFFSGDADTRAAEVPAASQPLTVSQGGLPPRGPV---LSGDQEPTVHVPIL-E-R-QQPPfGAQGC 510
gi 1046908755  454 PHRAEQPSVCMYRgEMSSGDCNTRASQVPGNLQFLSLSQRCPRPRAPA---PAGEEDAIVGAVLPgE-ERQQELqGTPGC 529
gi 223468697   408 THRAEPPCQSVHQ-EFNSGDINARSLQDAGNSQSSALNQRGIMSKKSV---LSGDQEEPVGLPAP-D-SEILQLpGTQGC 481
gi 1040235727  565 ARRPGVPSRYMHHgELSSGSSHTRDHQIPEHGPLLSLNQAGVTPRGPAfpgESGDQEPPVRPRRP---AVQQLPrGIEGC 641
gi 655876419   435 ADKPGTPCKYVPGgEFSSGERNRRQLQDSENLEASSLSQGSVTPRGPA---LSNDQEPP-VRPRR-P-ARQQLPpGIEGC 508
gi 672032419   454 PHRAEQPSVCMYRgEMSSGDCNTRASQVPGNLQFLSLSQRCPRPRAPA---PAGEEDAIVGAVLP-GeERQQELqGTPGC 529
gi 344257394   453 THRAEQPSTCTNRrEMTSGDANFRAPQVPGHSQLLTLSQRSSRSRALA---PAGESLGF---------QSSEERqGMEGN 520
gi 672087813   440 PHRAEQPSVCMYRgEMSSGDCNTRASQVPGNLQFLSLSQRCPRPRAPA---PAGDQEIPLRLPFP-VgDRQYPVqGVGGC 515
                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 81905087    482 PRCPEL----------------QKEIEDLRKQLSALQA 503
gi 532114955   971 PRCVLL----------------QKEIDDLKEQLGMtkp 992
gi 514463358   511 PRCLVL----------------QKEIDDLREQLAVLQS 532
gi 1046908755  530 AQCLMF----------------QKEIDELKEQLGLAll 551
gi 223468697   482 PRCPEL----------------QKEIEDLRKQLSALQA 503
gi 1040235727  642 PRCVVL----------------ENEAENLREKLAIMRS 663
gi 655876419   509 SRRTML----------------QKEVHDLREQLAVVRS 530
gi 672032419   530 AQCLMF----------------QKEIDELKEQLAVmqa 551
gi 344257394   521 LRLCSFgglqpcslgfpvwvgrESTGDWVQAVLASGHI 558
gi 672087813   516 QQCLMF----------------QKEIDELKEQLAVmqa 537
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap