Conserved Protein Domain Family
RBM39linker

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pfam15519: RBM39linker 
linker between RRM2 and RRM3 domains in RBM39 protein
A conserved linker between the second and the third RRM domain in human RBM39 (CAPER) protein, also present in other RNA binding proteins, especially those involved in RNA splicing. This linker was implicated in interactions with ESR1 and ESR2. Preliminary results from JCSG suggest that this is a structured domain with a well defined fold.
Statistics
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PSSM-Id: 317865
View PSSM: pfam15519
Aligned: 97 rows
Threshold Bit Score: 30.2118
Threshold Setting Gi: 356575464
Created: 28-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121738179  413 LDDTDVAGVNFNNYSRDALMRKLartdepsepsaddkqkilrp----ktetkplpvnvnmasrcvlLRNMFDPAEEEGES 488
gi 341877935  318 dDIGDRQGFSLGAGGRQQLMAKLaqgtgsgmeltasaqmaa--------qhagnsqipsiatqcflLSNMFDPSKETEPN 389
gi 675854706  468 pthstSTGFNLGPTERLQLMAKLaegtgmqlpaaattais----------asnqavtppiatqcfmLSNMFDLKKQNAAN 537
gi 242015973  356 TDELDRSGIDLGATGRLQLMYKLaegtgmqippaaatalnla-----nalpqavqpappiatqcfmLANMFDPATETNPT 430
gi 568253800  395 TDEMDRSGIELGATGRLQLMFKLaegaglavpraaadallatap--qpipqqplqqsppiatqcflLSNMFDPSTETNPN 472
gi 195050249  458 TDEMDRSGIDLGATGRLQLMFKLaegaglavpqaaanallatap--qpapmqheqqtpsiatqcfiLSNMFDPRTETNPT 535
gi 1008440449 342 SDELDRSGIDLGATGRLQLMFKLaegagmqvpqaaanalsiatg-qpvvpqvqtnstppiatqcfmLSNMFDPATESTQT 420
gi 215820612  328 VDELDRAGYDLGATGRLQLMYKLaegtgfpipqaaanalqvasgvqaapaaptvqvtppiatqcflLANMFDPNKEDvds 407
gi 307195359  200 TDELDRSGIDLGATGRLQLMFKLaegtgleippaaanalnmapv--mtapqpppqaappiatqcfmLSNMFDPQNETNPN 277
gi 671405615  218 TDDADRRGIDLGTSGRLHLMAKLaegsglelpksakeilaqnqq-qlesatvtgpaippiatqcfmLSNMFDPSQETGET 296
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