Conserved Protein Domain Family
Ntox11

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pfam15521: Ntox11 
Novel toxin 11
A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin contains two structural domains, an N-terminal alpha/beta domain and a C-terminal all-beta domain. The domain contains conserved GxR, RxxxoH GxE and GxxH motifs and a conserved histidine residue. In bacterial polymorphic toxin systems, the toxin is usually exported by the Photorhabdus virulence cassette (PVC)-type export system.
Statistics
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PSSM-Id: 317866
View PSSM: pfam15521
Aligned: 5 rows
Threshold Bit Score: 296.005
Threshold Setting Gi: 260652634
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122309735 293 GRHQQA-TQVLRNVFYLLHSq---------------------------lELYAGKKNQGQYQlHTG------NVAKVLSH 338
gi 524078503 351 ERNAQS-QLFIAKTMLMCHM-----------------------------GTFTLKDSKHNTE-GSWq----gPVSNAFAH 395
gi 290986912 148 ALEKKR-IDILRRMFIVLRY-----------------------------GDLLYRKSKKTNDwMPWselkglPIATAMSH 197
gi 260652634  50 ERERDR--QIRETAVDTLHpagiaperlhpdgipdtgpttakgkgrstaSDFAAKDARGPRDaHQGpahpaeRAEAVRPE 127
gi 291572118 628 QEQTDSaIAILKRVFIVLQ------------------------------HGLMYRDDQDKPKfEEWq----eNVAVALSH 673
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122309735 339 GGR------------------VNIRIPA-------------------LG---DSKENPHALMEWLgiTHE------AGEL 372
gi 524078503 396 CSR------------------VGIVLPG-------------------MEnaaYTKEGERSLINAY--TGK------NGGL 430
gi 290986912 198 GSR------------------IIIQLPKsamaaekkgifsklkntlrPK---DESSHDHGFWTWLlcGDE------NGSL 250
gi 260652634 128 GGDprgrlrqgrhpgprprrgVNLRIPA-------------------LR---SADEPAFSLPEFLgvIQDdrtntrAGDV 185
gi 291572118 674 GGR------------------VMINLP--------------------PL---GGTEKQHEFIYWLl----------GGTV 702
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122309735 373 D-----------------SHdaVFSRLAGTH------------------HVRIGDNKAGQSGSFKETGGMMaainaklhF 417
gi 524078503 431 D-----------------AG--FFVRGGATHt-----------------LFRKSKEKALIKTGFKELKFFS--------P 466
gi 290986912 251 EmvvtpettngseaakkgYL--LFKRTAATHslgyyt-------deikdEESPSSPAGGKKKKVKQLRRITanytdqnnQ 321
gi 260652634 186 I-----------------------DRGFATH------------------RTSITANKEGKPGAFKEKGGPLasvtnmvsV 224
gi 291572118 703 Q-----------------------KDKPKSHdhkdvdtssdyyraqvdtRIASSHDVEVTKNSLKELKGDTldiv----- 754
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122309735 418 D------------------------------------HLMGMNLAVGGLGKK----------------------DFNGDV 439
gi 524078503 467 W------------------------------------HQRGMNVAVGGLGNSgit-----------------gpDGTERI 493
gi 290986912 322 RgtmkklkdiieikeklglntrnskllgskeevmlkhRHWGLNVSMSGFGKKlpvflpykeakkarkkgpkkgsKVSYTT 401
gi 260652634 225 Gad--------------------------------rpDLWGQNLSGGGLGSK----------------------DWNGDV 250
gi 291572118 755 ----------------------------------gtiKHYGMDIPLGGLGNE----------------------DMAGDV 778
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122309735 440 ILPDGAHGHMFIGFREPTLKRDGVLQIGIETTEPGGFSTVGYIHNWRSSEkTanpVSSVGGLKKDKVGDGs-------KN 512
gi 524078503 494 LKNDGSCGHIYMHLEEGDSTNYTSMLVGFESDSYKKTNQLGHTHGFGNGE-F---ASSFGGQRLDEIGDK--------YG 561
gi 290986912 402 VEPTGEHSHIYLYYMSPGPKRYGGIMIGVEGSEPGKKDQSGEHHGITAGSpF---IGVTDGMKWNKIKDMgmeeypdkYD 478
gi 260652634 251 VLSDGTHGHMLLVHHRPTTRKDGSLQIGIETLAPHATSPVGYEHGFRSTEaTanpESVLHGHKGDKIGSGgl-----gKN 325
gi 291572118 779 ILPDGRHGHMYIYYRPPSSKEPGSVLIGAETSRMAHTDVFGMYHDQRGAPaE---VSSTGTSKAGRIGAE--------FG 847
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 122309735 513 ARTIDLAKVG----EGDWKKRLDEIRSHFEGKLsaa-qdEQAQKE 552
gi 524078503 562 GRNLDLTGIP----AAVFKNVMQKFETNFLRLQ------KEAAKN 596
gi 290986912 479 SLFIDL--------SSGWEFLKDKVNEWRDEMVfetiyiKPAQEA 515
gi 260652634 326 ERLVElaeMgaahsSGDWRTFLDEIKKQWDAAPaetedgSPARRA 370
gi 291572118 848 GRVVDyttL-----SQDGKSLTVKDPKWLEEL-------KEAEKN 880
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