Conserved Protein Domain Family
Imm21

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pfam15589: Imm21 
Immunity protein 21
A predicted immunity protein with an alpha+beta fold and conserved WxG and YxxxC motif. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbor of the toxin gene, usually containing a domain of the NGO1392-family of HNH/Endonuclease VII fold nucleases.
Statistics
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PSSM-Id: 317910
View PSSM: pfam15589
Aligned: 13 rows
Threshold Bit Score: 184.511
Threshold Setting Gi: 491455296
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123512142    6 DWIKSGGGPLVCIERGNAAQWLG--------VGGTNFGNGIHtkfsSDYERACDVQDYLGVILL-----NTGF--AVVLG 70
8_pfamImport    1 TWVSSAGGPLLVAPQSALSLWSG--------ADSTDGPVESW----GDYGRACAIDGYVGVVAI-----GQRQ--ALVLG 61
9_pfamImport    1 DWVESMGGPLIVIPVSALDAWRG--------CTESGMVVGDGvd-pDDYDRACAVDDLAGAIAVg---kDGTE--ALVLG 66
2_pfamImport    1 -WVESMGGPLIVVPVSALAVWRG--------CTETGVMVGDAta-pDDYDRACAVDGPAGVITVg---eNGAQ--ALVLA 65
10_pfamImport   1 RWVESGGGPLIAVPETVLPFWAG--------ADGDETA--------SDYDRACEIDGPVGLLPV-----GDSA--ALVLG 57
11_pfamImport   1 ---ESGGGPLIAVPETVLPFWAG--------ADSEDLD--------TDYDRACEVDGYVGLLPV-----GDSA--ALVFG 54
5_pfamImport    1 RWVESGGGPLIAVPEAVLPFWAG--------ADGDETS--------SDHDRACDLDGHVGLLPV-----GDSR--ALVLG 57
gi 81528889    11 EWVESGGGPLIAVPETVLPFWTG--------ADGEETD--------SDYDRACEVDGQVGLLPV-----GDST--ALVLG 67
4_pfamImport    1 EWVESGGGPLIAVPETVLTFWAG--------ADGDETA--------SDYDRACEVDGCVGLLPV-----GDAA--ALVLG 57
gi 502917130   15 TWIESMGGPLLAIPVSLLPAWEG--------CTETGMIWGETdt-pDDYDRACTVDGLAGVIAV-----GDGDgrALVLG 80
gi 502786056   11 TWVETDGGPIVVLQAATAARWSG--------VDGTDDSDDVTt--wGDYGRACTVDEYHGLVEFds-aqPPLT--ALVLG 77
gi 500933891    5 QWVDSSGGPLVLISDKSAEFWSGilkrsaylAKIKEDVEDFLdpneTDYGKACMINNYLGLVKV-----QNED--VLVIA 77
gi 491455296    4 aWVESEGGPMIAVEESLRHLWGG--------YANT------------DYETACAVEGPAGLVPFeeqsaGPGS--ALVIG 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123512142   71 DMPLETR--VsygTGDVPFIVRIFYADQ-----GVDVVEKLNDLKV--LDEIDPVesVNVEIReREIVIFDSAYPFSE-V 140
8_pfamImport   62 DEPAMTT--Y---LSSERLFLRWAAAYE-----EDDLVSAARRAVRd-GVDWDADnnVRWVVD-GPVVMFDSAWPGAE-L 128
9_pfamImport   67 DEPATTC--Y---MAEHRAFLRWLAADS-----EAGLKAAAEAVLAdpATQWEEC--GTWITD-GPAVLMDSAEAGAE-L 132
2_pfamImport   66 DEPAPSC--F---LPEHRAFLRWLAADS-----EVELKAAARTVLAnpATEWEEC--GTWSSD-GPAVLMDSAEAGSA-L 131
10_pfamImport  58 DEPAATA--Y---LPDHGTFVRWCAADS-----EAELLSGVPSALA--TAEWGEE--VRWKVP-GPVFLFDSAWPGTE-T 121
11_pfamImport  55 DEPASTS--F---LPDHATFVRWSAANS-----EAELLATVPAALE--AAVWGSE--VHWRVP-GPVLLFDSAWPGQA-A 118
5_pfamImport   58 REPAATT--Y---LPEHAAFVRHHAADSaagpfADGPLADVAAALD--AAGWEPE--VRWRVP-GPVVLFDAARPGRT-V 126
gi 81528889    68 DEPASTA--Y---LPDHGAFVRWCAADS-----EDEVLARVPAALD--AAEWQPE--VSWHVS-GPVLLFDAAWPGSA-S 131
4_pfamImport   58 DEPASTS--Y---LPDHDTFVRWCAADS-----EDELLAVVPTALA--AAVWEDE--VSWTVP-GPVVLFDAAWPG---- 118
gi 502917130   81 DGPDPGC--Y---LPEHRAFLRWIAADS-----EADLRAAAEAVLAdsAVEWEEC--GVWVTD-GPVVLMDSVTPGSS-P 146
gi 502786056   78 DEPQSST--Y---LPKHRVIARWTCADS-----EDQLLDMIDTRIPd-A-HWQSP--LHWHVSaGGLVMFDSAYALAD-F 142
gi 500933891   78 DEPLSTSffF---VSEKPVLARWIYGED-----KASVNYFLLNIELdlIENWHFEfiIDFFSD-KQ-FLFDSVNSFDK-K 146
gi 491455296   62 DLPAPTT--F---MEEFGALVQWIAASS-----EVRLVDVVRQGIGf-VDEWEDG--PVVQVN-GRLALFDAALPGTQaA 127
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 123512142  141 G--------D------AYLSLDFQPGKYIVVSKLfEPDER 166
8_pfamImport  129 Ep-------D------NHLVIDLCPGEYRVRATY-RADGD 154
9_pfamImport  133 NveypggglP------PQAGVALPPGRWRVRAVHtEADEE 166
2_pfamImport  132 YtehpgggaP------SQASVALPAGRWRIRATHtKADEE 165
10_pfamImport 122 Er-------------aAPLCVTLTPGAYGVRAAWvSPGPE 148
11_pfamImport 119 Dr-------------tEHLRVSLEAGTYAVRAAYvQPGPE 145
5_pfamImport  127 Rd-------------gDHVRVELAPGRYGVRAARvATGPR 153
gi 81528889   132 Dr------aP------DRVRVALEPGRYAVRAAEvRPGPE 159
4_pfamImport  119 Dda----vnT------DHLKVSLTPGRYAVRAADvRPGPE 148
gi 502917130  147 DtvhpgegsP------ERAPVPLPAGRWRVSAAHaRTDEG 180
gi 502786056  143 G--------PggcateSPLHIDLPAGPYEVTLAFvATTDE 174
gi 500933891  147 I--------K------QYLEINIKKGCYKIFTSLfEPDDK 172
gi 491455296  128 A--------D------ELLLVDVEPAVYRLRTADiESDTG 153
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