Conserved Protein Domain Family
Ntox15

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pfam15604: Ntox15 
Novel toxin 15
A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses a most all-alpha helical fold and a conserved HxxD motif. In bacterial polymorphic toxin systems, the toxin is usually exported by the type 2, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion systems. This is shown to be a type IV secretion system protein that behaves as DNase.
Statistics
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PSSM-Id: 317920
View PSSM: pfam15604
Aligned: 7 rows
Threshold Bit Score: 176.99
Threshold Setting Gi: 754364784
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81777405   895 KFNPIEFRGQLSQQERGINKMKMSQWAANRAQFLQTKEESEDGSGRSEASAGDQRIFRDYLRGKIVEVRVrSLKETKDQA 974
gi 81731267   348 QKYLKTYSAQLRAQQDAINNMTAEEFKSARDSYKNLGRNPAADAMQRRMGKQMEREVAEKIQKSLVKKGV-DVREAIIQA 426
gi 499279472  351 TIDIDEFKRQMELQEQGLNNMSPQQMLANQAKYLANPAGMRALSEPLQAKARQEYRNDPRIQKKYVD------QYGPIQG 424
gi 499280706   99 PKQVEEFRRQLKEQQDEINRMEPDDLVRNIDKYRQQGRPTDDAANRRQSREDYRTDRTRELEEKYLSKGRnDYKE---QA 175
gi 754364784   13 KHDSEEFARQLKDQEKGMNELTVDEYLKNREKYIEQGRAIEGNAAQQAAR-------EKALNKKIEELFEnGMSWE--EV 83
gi 395140866  115 SQHPAEFARQLSRQYEALSYLTVDEYLKGRNLYNTQKRAPTPPSLELQ---------REDLEKKIVNRLVdDYRFDPDKA 185
gi 395143397  120 SQHPAEFARQLSRQYEALSYLTVDEYLKGRDLYKTNKRAPNSSAIETD---------RAGLEKQIVIRLVrEYRFDPDKA 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81777405   975 EKFADNWLGTRAALHGPDQIAAGgrMAGDAQA-----VgidessviefkkrtglvgVGSARINSSIGSQW-------KSR 1042
gi 81731267   427 KARAKEIKSTVAALHEPDMVAGG--WLSPDPV-----R------------------MGSSSVNSSIGGSW-------SSR 474
gi 499279472  425 PIKLGEYLDSAAALHNPDMIAGGkyNSVVDQTlpienR------------------IGGLSENSSMGSQWinpnrngHTR 486
gi 499280706  176 ANDVAEEMKKLAATHTLDLVAGGdgSISG---------------------------LGDKSINSSLGSQW-------KGR 221
gi 754364784   84 EKNANSWLKSQAALHNPDQIAGGkpln--------------------------iggMGDKRINSSIGSQW-------KYR 130
gi 395140866  186 EKKAVEAVQALAALHEPDQSLQGthQLAAGEI-----V------------------WGNSSVNSSIGGQH-------KAG 235
gi 395143397  191 EEKAAEAVQSLAALHEPDQSLQGthQLTSGEI-----V------------------WGNGPVNSSIGGQH-------KPG 240
                         170       180       190
                  ....*....|....*....|....*....|
gi 81777405  1043 ISKIDQAis-dDKKYPSDVKDKANMNVQLT 1071
gi 81731267   475 LKALDDA----VDSAMLDGNGGAKLNVRLN 500
gi 499279472  487 ASRLTEH----AKRQAANNCPSVQVDLRLC 512
gi 499280706  222 RSEQLRS----HAKKAAEQKKKMNAKLEEC 247
gi 754364784  131 IDIVDEQigelTKSLTSDQRKNTYLNVKLT 160
gi 395140866  236 LARLDEK----ARDAQVAGKGHRYLNVRVV 261
gi 395143397  241 VALLDKK----ARAAQQAGKGQHYLNVRVV 266
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