Conserved Protein Domain Family
Tox-HDC

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pfam15656: Tox-HDC 
Toxin with a H, D/N and C signature
A predicted alpha/beta fold peptidase domain with a strongly conserved triad of a histidine, aspartate/asparagine and cysteine residues that are predicted to comprise the active site of the predicted peptidase. Proteins bearing this predicted toxin domain are particularly common in both intracellular and extracellular pathogens.
Statistics
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PSSM-Id: 317959
View PSSM: pfam15656
Aligned: 3 rows
Threshold Bit Score: 177.053
Threshold Setting Gi: 81655373
Created: 30-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 81419313  1644 NGRTIWGSDTKIRGLDIKYP---LEQISRRPsNGDIVLLSGSHGVqngd-----nwlINGSRRGSL-----LHFPFFKSD 1710
gi 81655373  2233 QGAEVRLTTSMTNGAVVNNQv--MDALNKNP-NGKVYILTGTHGS------------PDGVRDRELn----AEMRFTMED 2293
gi 753818043 1470 NGKYIYNSHTKVNGYGVEKAyvnLKKISNKP----IDIISGSHGGnlgegnwveifgPNAKREGVIrnpsyLEHKFLMQD 1545
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 81419313  1711 MTVYGGSWKGRTVhVRNLATMSEIDFGTLLNNGNS--HIILGYCYGRNDQALRYHRNLLSVTSY 1772
gi 81655373  2294 TQNLPPAVRDRVV-VVDLAHATDEYVQNILINAQKgdTIIGGFCFSRNDGVIAGALGLEIKPSH 2356
gi 753818043 1546 LATLKKN-KGLTDrVYNIKNLDRNELNNILRNPNT--NVILGYCYSANDNYMASVDNRISSLIF 1606
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