Conserved Protein Domain Family
Tox-HNH-EHHH

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pfam15657: Tox-HNH-EHHH 
HNH/Endo VII superfamily nuclease toxins
A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteristic conserved [ED]H motif and two histidine residues. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 5, type 6, type 7 or Photorhabdus virulence cassette (PVC)-type secretion system.
Statistics
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PSSM-Id: 317960
View PSSM: pfam15657
Aligned: 31 rows
Threshold Bit Score: 47.0213
Threshold Setting Gi: 291151657
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123132931 1512 ILGNDKHPIMTRELTY-QLNGKNVIIQDHSAGHYYneggvgDQPSHHNVRPE---D------------------N----- 1564
gi 446172091  232 IFDGTSEHRW--VEEYvNIKNEKVYIIEHREDKM-------GRGSHFHTADD---E------------------Kgs--- 278
gi 491586509 1426 YRHSEDLGTHGRYMQFeTENG-SRVIAEHTSDPNA-------PGPHFHAGQP---KgdpsregvdfgwstasnnD----- 1489
gi 739942168 1486 HVYSSDPTHWGNFRQFeTPNG-SRVVVEHTDDP---------AGPHFHAGGP---K------------------Gstled 1534
gi 188028061  197 VYDNKFENRT--VYEF-NVDGKKKYIIKHEDDKF-------GRGPHFHGADDlkeN------------------P----- 243
gi 331080559   68 YKYSEDLGSHGRYYEYtDAYGRKKVVVEHTADPRA-------PGPHAHAGQP---K------------------Pgadpr 119
gi 872717822  422 AVDKRGNPIPGRDYHFkDGK----IIREHSGGHTYpddpsqnRGSHFN-------------------------------- 465
gi 549462581  390 YEFSSNPTHHGRYFEYeTPQ-GKRVIVEHINDGRM----------HTHAGKP---K------------------Dganpf 437
gi 228829053  227 IFDGTSEHRW--VEEYvNIKnEKVYIIEHREDKMG-------RGSHFHTADD---E------------------Kgs--- 273
gi 291151657   38 VFDSKYENRT--VWEF-NHSgDKKYILMHEDDKFG-------RGPHLHTADD---L------------------Hgn--- 83
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 123132931 1565 ----------------------TRTGKVDGMDDHYHF 1579
gi 446172091  279 ---------------------pLEKGRYHQHPGHYPE 294
gi 491586509 1490 ----------------------IERYSQIGGSHHMFY 1504
gi 739942168 1535 qsrsgvnfgwdntvdgygtmerYRAIDKPGGDHHFFY 1571
gi 188028061  244 ----------------------MKPGKYNQYPGHYPE 258
gi 331080559  120 ty-------------dfksdryQKINDPVTKDHHIYY 143
gi 872717822  466 ----------------------------DVHGNHYDY 474
gi 549462581  438 ny--------------dfkkerYSNIYGSNKDHHIYY 460
gi 228829053  274 ---------------------pLEKGRYHQHPGHYPE 289
gi 291151657   84 --------------------plEKNVRYNQHPGHIPE 100
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