Conserved Protein Domain Family
HGAL

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pfam15666: HGAL 
Germinal center-associated lymphoma
HGAL is a family of mammalian sequences typically between 104 and 179 amino acids in length. Members were discovered in a search for proteins precipitating diffuse large B-cell lymphomas. HGAL interacts with the cytoskeleton and aids the activity of interleukin-6 on cell migration. It also modulates the RhoA signalling pathway.
Statistics
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PSSM-Id: 317969
View PSSM: pfam15666
Aligned: 24 rows
Threshold Bit Score: 93.9178
Threshold Setting Gi: 884943757
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 884912436  48 QDNGTQSYTGEVCYILVNHTALGRKPSGNSSEeeevtgELYENISCEARRPRESLGGTETEYSLLRVSSPPSHPPC-PED 126
gi 346421355  74 EENVDQSSVEDLCYTLIDHSTPARRPIGTPAE------ECYENVSLKTERPRESLGGTETEYSLIHVSSTLGHPSS-SEN 146
gi 612017536  60 ETNEDN--AKEPFYALIMH-VPQRRPSTNSTD------DGYENVVPK-HMTKQLADRCETEYAVVRVPSSPQPSYSfQDE 129
gi 884943757 109 aQDEAGSSSEDLCYTVINHAA-QRWPSLASTD------HGYENVSTTRRGGRRFREESETEYALLR-TAAMGPCSCtPEH 180
gi 545552810  73 QDSADQSSSEDLCYTLINHSVLGGKSSGISAE------RCYENISPKTETPRESLGKTEVSYALLRVPSSPRHSSS-PED 145
gi 281352107   1 QDNVDQSSSEDLCYTLINHSVPRGRPSEISSE------GCYENVSPKTETPRKSLGETETSYALLRVPSSPRHFSS-PEE 73
gi 803333785  56 QENENVSGCEEVCYTVINHRP-YRRPSLNSSD------DGYENI---TKRVRPLREGPETEYALLKKPCTIRSSSCtAEN 125
gi 664778735  24 QGNETSCGSEEVSYSVINH----RRPSLSSND------DGYENVDPTTERVRPLREGSETEYTLLRLTCLTRPSSCtPEN 93
gi 545506618  56 QENENGSGSEELCYSVISHRP-CRRPSLSSND------DGYENIDSTTKRVRTYRDAPETEYALIKMTCVTRPSSCsLEH 128
gi 755763640  50 QDNADQSSLEDLSYTLINHSVLGRRSSGISG-------AYYENISPNTKRPREFLRRTETSYALLHVPSSPRHLPS-PED 121

                 ....*..
gi 884912436 127 EYELLMP 133
gi 346421355 147 EYELLMP 153
gi 612017536 130 EYELIMP 136
gi 884943757 181 DYELVLP 187
gi 545552810 146 AYELIIP 152
gi 281352107  74 EYELVMP 80
gi 803333785 126 DYEIVLP 132
gi 664778735  94 DYEVVLP 100
gi 545506618 129 DYELVLP 135
gi 755763640 122 EYELLTP 128
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